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ChemicalBook >> CAS DataBase List >> 4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID

4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID price.
  • $24 - $2565
  • Product name: 4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID
  • CAS: 102121-60-8
  • MF: C22H25NO3
  • MW: 351.44
  • EINECS:
  • MDL Number:MFCD00673916
  • Synonyms:4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid;NSC 608001;4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid;benzoicacid,4-((5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbony ;l)amino- ;ro40-6055 ;AM 580;4-[(5,6,7,8-TETRAHYDRO-5,5,8,8-TETRAMETHYL-2-NAPHTHALENYL)CARBOXAMIDO]BENZOIC ACID
Price97 Properties Safety Information Description
97 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • TCI Chemical
  • Thermo Scientific Chemicals
  • Tocris
  • TRC
  • Usbiological
Package
  • 2mg
  • 10mM*1mLinDMSO(Solution)
  • 500mg
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  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10
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  • 25.00mg
  • 10mM*1mLinDMSO
  • 100.00mg
  • 1mg
  • 10mM(in1mLDMSO)
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 250mg
  • 1G
  • 100mg
  • 10mM(in 1mL DMSO)
  • Manufactureraablocks
  • Product numberAA0006LM
  • Product description4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid 98%
  • Packaging1mg
  • Price$24
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA0006LM
  • Product description4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid >98.0%(HPLC)
  • Packaging5mg
  • Price$46
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA0006LM
  • Product description4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid
  • Packaging10mg
  • Price$84
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA0006LM
  • Product description4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid >98.0%(HPLC)
  • Packaging25mg
  • Price$136
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA0006LM
  • Product description4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid 98%
  • Packaging50mg
  • Price$236
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA0006LM
  • Product description4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid >98.0%(HPLC)
  • Packaging100mg
  • Price$372
  • Updated2026-05-25
  • Buy
  • Manufactureraablocks
  • Product numberAA0006LM
  • Product description4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid ≥98%
  • Packaging250mg
  • Price$782
  • Updated2026-05-25
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  • ManufacturerACHEMBLOCK
  • Product number10262
  • Product descriptionAM580 98%
  • Packaging1G
  • Price$1050
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10262
  • Product descriptionAM580 98%
  • Packaging1G
  • Price$1050
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10262
  • Product descriptionAM580 98%
  • Packaging100MG
  • Price$350
  • Updated2026-05-25
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10262
  • Product descriptionAM580 98%
  • Packaging100MG
  • Price$350
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10262
  • Product descriptionAM580 98%
  • Packaging25MG
  • Price$125
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10262
  • Product descriptionAM580 98%
  • Packaging25MG
  • Price$125
  • Updated2026-05-25
  • Buy
  • ManufacturerAK Scientific
  • Product number3437AH
  • Product description4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoicacid
  • Packaging5mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008429
  • Product descriptionAM 580 95.00%
  • Packaging1MG
  • Price$135.45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008429
  • Product descriptionAM 580 95.00%
  • Packaging50MG
  • Price$1170.31
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0006LM 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid 98% 1mg $24 2026-05-25 Buy
aablocks AA0006LM 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid >98.0%(HPLC) 5mg $46 2026-05-25 Buy
aablocks AA0006LM 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid 10mg $84 2026-05-25 Buy
aablocks AA0006LM 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid >98.0%(HPLC) 25mg $136 2026-05-25 Buy
aablocks AA0006LM 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid 98% 50mg $236 2026-05-25 Buy
aablocks AA0006LM 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid >98.0%(HPLC) 100mg $372 2026-05-25 Buy
aablocks AA0006LM 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoic acid ≥98% 250mg $782 2026-05-25 Buy
ACHEMBLOCK 10262 AM580 98% 1G $1050 2026-05-25 Buy
ACHEMBLOCK 10262 AM580 98% 1G $1050 2026-05-27 Buy
ACHEMBLOCK 10262 AM580 98% 100MG $350 2026-05-25 Buy
ACHEMBLOCK 10262 AM580 98% 100MG $350 2026-05-27 Buy
ACHEMBLOCK 10262 AM580 98% 25MG $125 2026-05-27 Buy
ACHEMBLOCK 10262 AM580 98% 25MG $125 2026-05-25 Buy
AK Scientific 3437AH 4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]benzoicacid 5mg $150 2021-12-16 Buy
American Custom Chemicals Corporation API0008429 AM 580 95.00% 1MG $135.45 2021-12-16 Buy
American Custom Chemicals Corporation API0008429 AM 580 95.00% 50MG $1170.31 2021-12-16 Buy
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Properties

Melting point :265-267℃
Boiling point :485.24°C (rough estimate)
Density :1.154
refractive index :1.5614 (estimate)
storage temp. :-20°C
solubility :Soluble in DMSO (20mg/ml) or ethanol (10mg/ml).
form :White to off-white solid.
pka :4.28±0.10(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
InChIKey :SZWKGOZKRMMLAJ-UHFFFAOYSA-N
SMILES :CC1(C)CCC(C)(C)c2cc(ccc12)C(=O)Nc3ccc(cc3)C(O)=O

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

AM580 is a retinoic acid receptor agonist that is selective for RARα (Kd = 8 nM; AC50 = 0.36 nM) compared to RARβ (Kd = 131 nM; AC50 = 24.6 nM) and RARγ (Kd = 450 nM; AC50 = 27.9 nM). It demonstrates greater specific binding to RARα compared to retinoic acid , which exhibits little selectivity across RARα, β, or γ. AM580 has been used in combination with the GSK3β inhibitor CHIR99021 to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm. It can also inhibit the proliferation of various tumor cells, inhibiting survival signaling pathways and inducing apoptosis.

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