Troglitazone
|
- $19 - $2318
- Product name: Troglitazone
- CAS: 97322-87-7
- MF: C24H27NO5S
- MW: 441.54
- EINECS:
- MDL Number:MFCD00878416
- Synonyms:Troglitazone(CS-045);RESULIN(TM);ROMGLIZONE;5-(4-(6-hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2 ;ci991 ;enzopyran-2-yl)methoxy)phenyl)methyl)- ;gr92132x ;rezulin
95 prices
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Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AHH
- AK Scientific
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 50
- 2mg
- 1mg
- 10
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 0.5g
- 1G
- 10mM*1mLinDMSO(Solution)
- 1 unit
- 5 mg
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA00JNII
- Product description5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98%
- Packaging10mg
- Price$57
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00JNII
- Product description5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98%
- Packaging25mg
- Price$95
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00JNII
- Product description5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98%
- Packaging50mg
- Price$151
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00JNII
- Product description5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98%
- Packaging100mg
- Price$238
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00JNII
- Product description5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98%
- Packaging250mg
- Price$399
- Updated2026-05-29
- Buy
- Manufactureraablocks
- Product numberAA00JNII
- Product description5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98%
- Packaging1mg
- Price$19
- Updated2026-05-29
- Buy
- ManufacturerACHEMBLOCK
- Product numberS87327
- Product descriptionTroglitazone 98%
- Packaging1G
- Price$1200
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS87327
- Product descriptionTroglitazone 98%
- Packaging1G
- Price$1200
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS87327
- Product descriptionTroglitazone 98%
- Packaging100MG
- Price$240
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS87327
- Product descriptionTroglitazone 98%
- Packaging100MG
- Price$240
- Updated2026-05-25
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3565-M005
- Product descriptionTroglitazone ≥98%
- Packaging5mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3565-M025
- Product descriptionTroglitazone ≥98%
- Packaging25mg
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3565-M005
- Product descriptionTroglitazone ≥98%
- Packaging5mg
- Price$60
- Updated2026-05-06
- Buy
- ManufacturerAHH
- Product numberAPI-1400
- Product descriptionTroglitazone 98%
- Packaging0.5g
- Price$620
- Updated2021-12-16
- Buy
- ManufacturerAHH
- Product numberAPI-1400
- Product descriptionTroglitazone 97%
- Packaging0.5g
- Price$620
- Updated2026-05-26
- Buy
- ManufacturerAK Scientific
- Product numberK752
- Product descriptionTroglitazone
- Packaging50mg
- Price$397
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00JNII | 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98% | 10mg | $57 | 2026-05-29 | Buy |
| aablocks | AA00JNII | 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98% | 25mg | $95 | 2026-05-29 | Buy |
| aablocks | AA00JNII | 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98% | 50mg | $151 | 2026-05-29 | Buy |
| aablocks | AA00JNII | 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98% | 100mg | $238 | 2026-05-29 | Buy |
| aablocks | AA00JNII | 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98% | 250mg | $399 | 2026-05-29 | Buy |
| aablocks | AA00JNII | 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione 98% | 1mg | $19 | 2026-05-29 | Buy |
| ACHEMBLOCK | S87327 | Troglitazone 98% | 1G | $1200 | 2026-05-25 | Buy |
| ACHEMBLOCK | S87327 | Troglitazone 98% | 1G | $1200 | 2026-05-27 | Buy |
| ACHEMBLOCK | S87327 | Troglitazone 98% | 100MG | $240 | 2026-05-27 | Buy |
| ACHEMBLOCK | S87327 | Troglitazone 98% | 100MG | $240 | 2026-05-25 | Buy |
| Adipogen Life Sciences | AG-CR1-3565-M005 | Troglitazone ≥98% | 5mg | $55 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3565-M025 | Troglitazone ≥98% | 25mg | $210 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-3565-M005 | Troglitazone ≥98% | 5mg | $60 | 2026-05-06 | Buy |
| AHH | API-1400 | Troglitazone 98% | 0.5g | $620 | 2021-12-16 | Buy |
| AHH | API-1400 | Troglitazone 97% | 0.5g | $620 | 2026-05-26 | Buy |
| AK Scientific | K752 | Troglitazone | 50mg | $397 | 2021-12-16 | Buy |
Properties
Melting point :184-186°C
Boiling point :657.0±55.0 °C(Predicted)
Density :1.266±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: 20 mg/mL
form :solid
pka :6.34±0.50(Predicted)
color :white to yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
InChIKey :GXPHKUHSUJUWKP-UHFFFAOYSA-N
SMILES :S1C(CC2=CC=C(OCC3(C)OC4=C(C)C(C)=C(O)C(C)=C4CC3)C=C2)C(=O)NC1=O
CAS DataBase Reference :97322-87-7(CAS DataBase Reference)
Boiling point :657.0±55.0 °C(Predicted)
Density :1.266±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: 20 mg/mL
form :solid
pka :6.34±0.50(Predicted)
color :white to yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
InChIKey :GXPHKUHSUJUWKP-UHFFFAOYSA-N
SMILES :S1C(CC2=CC=C(OCC3(C)OC4=C(C)C(C)=C(O)C(C)=C4CC3)C=C2)C(=O)NC1=O
CAS DataBase Reference :97322-87-7(CAS DataBase Reference)
Safety Information
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Description
Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes, under the trade name Resulin?, but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPARγ agonist. The EC50 values for transactivation of human and mouse PPARγ in a cell-based assay are 0.55 and 0.78 μM, respectively. In the same assay system, no activation of PPARα and PPARδ was observed at concentrations up to 10 μM. Troglitazone binds to the PPARγ ligand-binding domain (LBD) but fails to induce interaction of the PPARγ LBD with the transcriptional coactivators SRC-1, TIF2, AIB1, p300, or TRAP220. Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 μM.Related product price
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Suppliers and manufacturers
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