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ChemicalBook >> CAS DataBase List >> 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-

3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-

3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]- price.
  • $121 - $3811.5
  • Product name: 3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-
  • CAS: 1033836-12-2
  • MF: C19H19F4N3O
  • MW: 381.37
  • EINECS:
  • MDL Number:MFCD18206776
  • Synonyms:HPGDS inhibitor 1;6-(3-Fluorophenyl)-N-[1-(2,2,2-trifluoroethyl)-4-piperidinyl]-3-pyridinecarboxamide;3-PYRIDINECARBOXAMIDE, 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-;6-(3-fluorophenyl)-N-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)nicotinaMide;HPGDS inhibitor 1, >=98%;Prostaglandin D Synthase (hematopoietic-type) Inhibitor I;CS-1438;MDK36122
14 prices
Selected condition:
Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 100mg
  • 250mg
  • 1g
  • 1000mg
  • 5G
  • ManufacturerAmbeed
  • Product numberA414719
  • Product descriptionHPGDSinhibitor1 98+%
  • Packaging100mg
  • Price$1282
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberHCH0316558
  • Product description6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-3-PYRIDINECARBOXAMIDE 95.00%
  • Packaging5G
  • Price$3811.5
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1046
  • Product descriptionHPGDSinhibitor1
  • Packaging100mg
  • Price$2051
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181253
  • Product descriptionHPGDS-inhibitor-1 >98%
  • Packaging100mg
  • Price$765
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181253
  • Product descriptionHPGDS-inhibitor-1 >98%
  • Packaging250mg
  • Price$1504.5
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181253
  • Product descriptionHPGDS-inhibitor-1 >98%
  • Packaging1000mg
  • Price$2691.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number16256
  • Product descriptionProstaglandin D Synthase (hematopoietic-type) Inhibitor I ≥98%
  • Packaging1mg
  • Price$121
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16256
  • Product descriptionProstaglandin D Synthase (hematopoietic-type) Inhibitor I ≥98%
  • Packaging5mg
  • Price$302
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number16256
  • Product descriptionProstaglandin D Synthase (hematopoietic-type) Inhibitor I ≥98%
  • Packaging10mg
  • Price$543
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1801
  • Product descriptionHPGDSinhibitor1 99.32%
  • Packaging100mg
  • Price$1680
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31004772
  • Product descriptionHPGDSinhibitor1 98+%
  • Packaging100mg
  • Price$250
  • Updated2021-12-16
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  • ManufacturerCrysdot
  • Product numberCD31004772
  • Product descriptionHPGDSinhibitor1 98+%
  • Packaging250mg
  • Price$430
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7424
  • Product descriptionHPGDS-inhibitor-1 >98%
  • Packaging250mg
  • Price$1000
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7424
  • Product descriptionHPGDS-inhibitor-1 >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A414719 HPGDSinhibitor1 98+% 100mg $1282 2021-12-16 Buy
American Custom Chemicals Corporation HCH0316558 6-(3-FLUOROPHENYL)-N-[1-(2,2,2-TRIFLUOROETHYL)-4-PIPERIDINYL]-3-PYRIDINECARBOXAMIDE 95.00% 5G $3811.5 2021-12-16 Buy
ApexBio Technology B1046 HPGDSinhibitor1 100mg $2051 2021-12-16 Buy
Biorbyt Ltd orb181253 HPGDS-inhibitor-1 >98% 100mg $765 2021-12-16 Buy
Biorbyt Ltd orb181253 HPGDS-inhibitor-1 >98% 250mg $1504.5 2021-12-16 Buy
Biorbyt Ltd orb181253 HPGDS-inhibitor-1 >98% 1000mg $2691.1 2021-12-16 Buy
Cayman Chemical 16256 Prostaglandin D Synthase (hematopoietic-type) Inhibitor I ≥98% 1mg $121 2024-03-01 Buy
Cayman Chemical 16256 Prostaglandin D Synthase (hematopoietic-type) Inhibitor I ≥98% 5mg $302 2024-03-01 Buy
Cayman Chemical 16256 Prostaglandin D Synthase (hematopoietic-type) Inhibitor I ≥98% 10mg $543 2024-03-01 Buy
ChemScene CS-1801 HPGDSinhibitor1 99.32% 100mg $1680 2021-12-16 Buy
Crysdot CD31004772 HPGDSinhibitor1 98+% 100mg $250 2021-12-16 Buy
Crysdot CD31004772 HPGDSinhibitor1 98+% 250mg $430 2021-12-16 Buy
DC Chemicals DC7424 HPGDS-inhibitor-1 >98% 250mg $1000 2021-12-16 Buy
DC Chemicals DC7424 HPGDS-inhibitor-1 >98% 1g $1800 2021-12-16 Buy

Properties

Boiling point :487.2±45.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :Soluble in DMSO
form :crystalline solid
pka :9.55±0.20(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Prostaglandin D2 is synthesized by PGD synthase (hematopoietic-type) (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis. Thus, H-PGDS is an important target for the development of inhibitors for therapeutic use against these diseases. H-PGDS inhibitor I selectively blocks HPGDS (IC50s = 0.7 and 32 nM in enzyme and cellular assays, respectively) with little activity against the related human enzymes L-PGDS, mPGES, COX-1, COX-2, and 5-LOX. It is orally bioavailable and has been shown to dampen airway hyper-responsiveness in a model of antigen-induced airway response in allergic sheep.

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