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ChemicalBook >> CAS DataBase List >> 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide

4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide

$100 - $1800
Product name: 4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
CAS: 108477-18-5
MF: C19H14N2O7S
MW: 414.39
EINECS:
MDL Number:MFCD28138111
Synonyms:4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide;NSC-144303;Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase Inhibitor I, G5;G5, Ubiquitin Isopeptidase Inhibitor I;Ubiquitin Isopeptidase-IN-G5;Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303);Ubiquitin Isopeptidase Inhibitor I, G5,Ubiquitin Isopeptidase Inhibitor I, G-5

Price19 Properties Safety Information Description

19 prices

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Brand

ACHEMBLOCK
AK Scientific
ApexBio Technology
Biosynth
Cayman Chemical
CSNpharm
DC Chemicals
Sigma-Aldrich
TRC

Package

5mg
10mg
25MG
50mg
100MG
250MG
1g

ManufacturerACHEMBLOCK
Product numberAD268620
Product descriptionUbiquitin Isopeptidase Inhibitor I, G5 98%
Packaging25MG
Price$110
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberAD268620
Product descriptionUbiquitin Isopeptidase Inhibitor I, G5 98%
Packaging100MG
Price$190
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberAD268620
Product descriptionUbiquitin Isopeptidase Inhibitor I, G5 98%
Packaging250MG
Price$340
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product number5032CP
Product descriptionUbiquitinIsopeptidaseInhibitorI,G5
Packaging5mg
Price$206
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberC3250
Product descriptionUbiquitin Isopeptidase Inhibitor I
Packaging10mg
Price$174
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberC3250
Product descriptionUbiquitin Isopeptidase Inhibitor I
Packaging5mg
Price$100
Updated2026-05-06
Buy

ManufacturerApexBio Technology
Product numberC3250
Product descriptionUbiquitin Isopeptidase Inhibitor I
Packaging25mg
Price$347
Updated2026-05-06
Buy

ManufacturerBiosynth
Product numberIEA47718
Product descriptionUbiquitin Isopeptidase Inhibitor I, G5
Packaging50mg
Price$1117.5
Updated2026-06-04
Buy

ManufacturerBiosynth
Product numberIEA47718
Product descriptionUbiquitin Isopeptidase Inhibitor I, G5
Packaging100mg
Price$1555
Updated2026-06-04
Buy

ManufacturerCayman Chemical
Product number21006
Product descriptionUbiquitin Isopeptidase Inhibitor I ≥98%
Packaging25mg
Price$396
Updated2026-04-30
Buy

ManufacturerCayman Chemical
Product number21006
Product descriptionUbiquitin Isopeptidase Inhibitor I ≥98%
Packaging5mg
Price$107
Updated2026-04-30
Buy

ManufacturerCayman Chemical
Product number21006
Product descriptionUbiquitin Isopeptidase Inhibitor I ≥98%
Packaging10mg
Price$193
Updated2026-04-30
Buy

ManufacturerCSNpharm
Product numberCSN21899
Product descriptionUbiquitinIsopeptidaseInhibitorI,G5
Packaging25mg
Price$265
Updated2021-12-16
Buy

ManufacturerCSNpharm
Product numberCSN21899
Product descriptionUbiquitinIsopeptidaseInhibitorI,G5
Packaging100mg
Price$836
Updated2021-12-16
Buy

ManufacturerDC Chemicals
Product numberDC10298
Product descriptionUbiquitin Isopeptidase Inhibitor I, G5 >98%
Packaging1g
Price$1800
Updated2026-05-24
Buy

ManufacturerDC Chemicals
Product numberDC10298
Product descriptionUbiquitin Isopeptidase Inhibitor I, G5 >98%
Packaging250mg
Price$900
Updated2026-05-24
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
ACHEMBLOCK	AD268620	Ubiquitin Isopeptidase Inhibitor I, G5 98%	25MG	$110	2026-05-27	Buy
ACHEMBLOCK	AD268620	Ubiquitin Isopeptidase Inhibitor I, G5 98%	100MG	$190	2026-05-27	Buy
ACHEMBLOCK	AD268620	Ubiquitin Isopeptidase Inhibitor I, G5 98%	250MG	$340	2026-05-27	Buy
AK Scientific	5032CP	UbiquitinIsopeptidaseInhibitorI,G5	5mg	$206	2021-12-16	Buy
ApexBio Technology	C3250	Ubiquitin Isopeptidase Inhibitor I	10mg	$174	2026-05-06	Buy
ApexBio Technology	C3250	Ubiquitin Isopeptidase Inhibitor I	5mg	$100	2026-05-06	Buy
ApexBio Technology	C3250	Ubiquitin Isopeptidase Inhibitor I	25mg	$347	2026-05-06	Buy
Biosynth	IEA47718	Ubiquitin Isopeptidase Inhibitor I, G5	50mg	$1117.5	2026-06-04	Buy
Biosynth	IEA47718	Ubiquitin Isopeptidase Inhibitor I, G5	100mg	$1555	2026-06-04	Buy
Cayman Chemical	21006	Ubiquitin Isopeptidase Inhibitor I ≥98%	25mg	$396	2026-04-30	Buy
Cayman Chemical	21006	Ubiquitin Isopeptidase Inhibitor I ≥98%	5mg	$107	2026-04-30	Buy
Cayman Chemical	21006	Ubiquitin Isopeptidase Inhibitor I ≥98%	10mg	$193	2026-04-30	Buy
CSNpharm	CSN21899	UbiquitinIsopeptidaseInhibitorI,G5	25mg	$265	2021-12-16	Buy
CSNpharm	CSN21899	UbiquitinIsopeptidaseInhibitorI,G5	100mg	$836	2021-12-16	Buy
DC Chemicals	DC10298	Ubiquitin Isopeptidase Inhibitor I, G5 >98%	1g	$1800	2026-05-24	Buy
DC Chemicals	DC10298	Ubiquitin Isopeptidase Inhibitor I, G5 >98%	250mg	$900	2026-05-24	Buy

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Properties

Melting point :233.5-234.5 °C
Boiling point :693.0±55.0 °C(Predicted)
Density :1.541±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C,unstable in solution, ready to use.
solubility :≤15mg/ml in DMSO;1mg/ml in dimethyl formamide
form :crystalline solid
color :Light yellow to yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Ubiquitin isopeptidase inhibitor I induces caspase activation and apoptosis (IC₅₀ = ~1.7 μM) through a Bcl-2-dependent and apoptosome-independent mitochondrial pathway that selectively inhibits ubiquitin isopeptidase activity (IC₅₀ = ~30 μM). It has also been shown to induce necrosis in apoptosis-resistant DKO cells.

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Suppliers and manufacturers

VDM Biochemicals SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD Shanghai EFE Biological Technology Co., Ltd. Alabiotech Inc. MQ (shanghai) Pharmaceuticals Co., Ltd. Heze Development Zone chuangli Chemical Co., Ltd. Alpha Biopharmaceuticals Co., Ltd Fan De(Beijing) Biotechnology Co., Ltd. TargetMol Chemicals Inc. InvivoChem

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4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide

Properties

Safety Information

Description

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