(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone
- $28 - $4766.8
- Product name: (1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone
- CAS: 128517-07-7
- MF: C24H36N4O6S2
- MW: 540.7
- EINECS:
- MDL Number:MFCD18433404
- Synonyms:FK228 RoMidepsin;5)-disulfide;Cyclo[(2Z)-2-aMino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-Mercapto-4-heptenoyl-D-valyl-D-cysteinyl],cyclic (3®(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone RoMidepsin (FK228, Depsipeptide);Romidepsin Antibiotic FR 901228;Romidepsin, >=98%;(1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[;FR 901228
32 prices
Selected condition:
Brand
- AK Scientific
- Ambeed
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 500μg
- 1unit
- 1mg
- 1
- 2mg
- 5mg
- 10mM(in 1mL DMSO)
- 10mg
- 25mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberSYN5338
- Product descriptionRomidepsin
- Packaging10mg
- Price$628
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging1mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging5mg
- Price$243
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging10mg
- Price$942
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging100mg
- Price$1416
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA380298
- Product descriptionRomidepsin 98+%
- Packaging250mg
- Price$1416
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8173
- Product descriptionRomidepsin(FK228,depsipeptide)
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8173
- Product descriptionRomidepsin(FK228,depsipeptide)
- Packaging1mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8173
- Product descriptionRomidepsin(FK228,depsipeptide)
- Packaging5mg
- Price$330
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8173
- Product descriptionRomidepsin(FK228,depsipeptide)
- Packaging10mM(in 1mL DMSO)
- Price$390
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60009
- Product descriptionRomidepsin ≥98%
- Packaging5mg
- Price$463
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134739
- Product descriptionRomidepsin >99%
- Packaging100mg
- Price$1431.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134739
- Product descriptionRomidepsin >99%
- Packaging250mg
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb134739
- Product descriptionRomidepsin >99%
- Packaging1g
- Price$4766.8
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR10656
- Product descriptionRomidepsin
- Packaging1mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFR10656
- Product descriptionRomidepsin
- Packaging2mg
- Price$125
- Updated2021-12-16
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
AK Scientific | SYN5338 | Romidepsin | 10mg | $628 | 2021-12-16 | Buy |
Ambeed | A380298 | Romidepsin 98+% | 1mg | $243 | 2021-12-16 | Buy |
Ambeed | A380298 | Romidepsin 98+% | 5mg | $243 | 2021-12-16 | Buy |
Ambeed | A380298 | Romidepsin 98+% | 10mg | $942 | 2021-12-16 | Buy |
Ambeed | A380298 | Romidepsin 98+% | 100mg | $1416 | 2021-12-16 | Buy |
Ambeed | A380298 | Romidepsin 98+% | 250mg | $1416 | 2021-12-16 | Buy |
ApexBio Technology | A8173 | Romidepsin(FK228,depsipeptide) | 1unit | $28 | 2021-12-16 | Buy |
ApexBio Technology | A8173 | Romidepsin(FK228,depsipeptide) | 1mg | $110 | 2021-12-16 | Buy |
ApexBio Technology | A8173 | Romidepsin(FK228,depsipeptide) | 5mg | $330 | 2021-12-16 | Buy |
ApexBio Technology | A8173 | Romidepsin(FK228,depsipeptide) | 10mM(in 1mL DMSO) | $390 | 2021-12-16 | Buy |
Arctom | CFN60009 | Romidepsin ≥98% | 5mg | $463 | 2021-12-16 | Buy |
Biorbyt Ltd | orb134739 | Romidepsin >99% | 100mg | $1431.4 | 2021-12-16 | Buy |
Biorbyt Ltd | orb134739 | Romidepsin >99% | 250mg | $2395.3 | 2021-12-16 | Buy |
Biorbyt Ltd | orb134739 | Romidepsin >99% | 1g | $4766.8 | 2021-12-16 | Buy |
Biosynth Carbosynth | FR10656 | Romidepsin | 1mg | $80 | 2021-12-16 | Buy |
Biosynth Carbosynth | FR10656 | Romidepsin | 2mg | $125 | 2021-12-16 | Buy |
Properties
Melting point :219-224°C
Boiling point :942.8±65.0 °C(Predicted)
Density :1.174
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml).
pka :11.33±0.60(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Boiling point :942.8±65.0 °C(Predicted)
Density :1.174
storage temp. :-20°C
solubility :Soluble in DMSO (up to 10 mg/ml).
pka :11.33±0.60(Predicted)
form :powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Safety Information
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Signal word: | Danger | ||||||||||||||||||||||||||||||||||||||||
Hazard statements: |
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Precautionary statements: |
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Description
Romidepsin, also known as FK228, is a natural bicyclic depsipeptide that, following reduction, selectively inhibits class I histone deacetylases (HDACs). Reduction of a disulfide bond on romidepsin within the cell generates a zinc-binding thiol, allowing potent inhibition of HDACs 1, 2, 3, and 8 (IC50s = 53, 39, 53, and 26 nM, respectively), with less potency against HDACs 4, 6, 7, and 9 (IC50s = 470, 330, 3,200, and 12,000 nM, respectively). Through its effects on HDACs, romidepsin has anti-cancer activities, particularly against certain T cell lymphomas.More related product prices
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