4-(3-(2H-1,2,3-Triazo-2-yl)phenylaMino)-2-((1R,2S)-2-aMinocyclohexylaMino) pyriMidine-5-carboxaMide
|
- $54 - $2245.7
- Product name: 4-(3-(2H-1,2,3-Triazo-2-yl)phenylaMino)-2-((1R,2S)-2-aMinocyclohexylaMino) pyriMidine-5-carboxaMide
- CAS: 1370261-96-3
- MF: C19H23N9O
- MW: 393.45
- EINECS:
- MDL Number:
- Synonyms:4-(3-(2H-1,2,3-Triazo-2-yl)phenylaMino)-2-((1R,2S)-2-aMinocyclohexylaMino) pyriMidine-5-carboxaMide acetate;2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide;4-(3-(2H-1,2,3-Triazo-2-yl)phenylaMino)-2-((1R,2S)-2-aMinocyclohexylaMino) pyriMidine-5-carboxaMide;PRT062607;4-(3-(2H-1,2,3-Triazo-2-y...;P505-15;p50515/p505-15;P505-15 HCl
16 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Crysdot
- TRC
Package
- 500μg
- 1mg
- 5MG
- 10mg
- 2x5mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0017265
- Product descriptionP505-15 95.00%
- Packaging5MG
- Price$248.6
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1936
- Product descriptionP505-15-PRT062607 99%
- Packaging2x5mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181105
- Product descriptionPRT062607 >98%
- Packaging100mg
- Price$578
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181105
- Product descriptionPRT062607 >98%
- Packaging250mg
- Price$1133.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181105
- Product descriptionPRT062607 >98%
- Packaging1000mg
- Price$2245.7
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17652
- Product descriptionBIIB-057 ≥98%
- Packaging500μg
- Price$54
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17652
- Product descriptionBIIB-057 ≥98%
- Packaging1mg
- Price$94
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17652
- Product descriptionBIIB-057 ≥98%
- Packaging5mg
- Price$207
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17652
- Product descriptionBIIB-057 ≥98%
- Packaging10mg
- Price$357
- Updated2024-03-01
- Buy
- ManufacturerCrysdot
- Product numberCD31003717
- Product descriptionPRT062607 98+%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003717
- Product descriptionPRT062607 98+%
- Packaging10mg
- Price$107
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31003717
- Product descriptionPRT062607 98+%
- Packaging50mg
- Price$381
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA604590
- Product description2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide
- Packaging500μg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA604590
- Product description2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide
- Packaging1mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA604590
- Product description2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide
- Packaging10mg
- Price$275
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA604590
- Product description2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide
- Packaging25mg
- Price$545
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0017265 | P505-15 95.00% | 5MG | $248.6 | 2021-12-16 | Buy |
| Axon Medchem | Axon1936 | P505-15-PRT062607 99% | 2x5mg | $154 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181105 | PRT062607 >98% | 100mg | $578 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181105 | PRT062607 >98% | 250mg | $1133.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181105 | PRT062607 >98% | 1000mg | $2245.7 | 2021-12-16 | Buy |
| Cayman Chemical | 17652 | BIIB-057 ≥98% | 500μg | $54 | 2024-03-01 | Buy |
| Cayman Chemical | 17652 | BIIB-057 ≥98% | 1mg | $94 | 2024-03-01 | Buy |
| Cayman Chemical | 17652 | BIIB-057 ≥98% | 5mg | $207 | 2024-03-01 | Buy |
| Cayman Chemical | 17652 | BIIB-057 ≥98% | 10mg | $357 | 2024-03-01 | Buy |
| Crysdot | CD31003717 | PRT062607 98+% | 5mg | $72 | 2021-12-16 | Buy |
| Crysdot | CD31003717 | PRT062607 98+% | 10mg | $107 | 2021-12-16 | Buy |
| Crysdot | CD31003717 | PRT062607 98+% | 50mg | $381 | 2021-12-16 | Buy |
| TRC | A604590 | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide | 500μg | $55 | 2021-12-16 | Buy |
| TRC | A604590 | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide | 1mg | $70 | 2021-12-16 | Buy |
| TRC | A604590 | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide | 10mg | $275 | 2021-12-16 | Buy |
| TRC | A604590 | 2-[[(1R,2S)-2-Aminocyclohexyl]amino]-4-[[3-(2H-1,2,3-triazol-2-yl)phenyl]amino]-5-pyrimidinecarboxamide | 25mg | $545 | 2021-12-16 | Buy |
Properties
Boiling point :707.6±70.0 °C(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :14.05±0.50(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 10 mg/ml
form :A crystalline solid
pka :14.05±0.50(Predicted)
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
BIIB-057 is a potent inhibitor of the non-receptor tyrosine kinase Syk (IC50 = 1 nM). It displays at least 80-fold selectivity for Syk over other kinases. BIIB-057 blocks B cell receptor-mediated cell signaling and activation in whole blood (IC50s = 0.27 and 0.28 μM, respectively), as well as Fc? receptor 1-mediated basophil degranulation (IC50 = 0.15 μM). It antagonizes chemokine production, cell migration, and survival of chronic lymphocytic leukemia (CLL) cells after B cell receptor activation and synergistically enhances the action of fludarabine in killing CLL cells. BIIB-057 is orally bioavailable, as it produces dose-dependent anti-inflammatory activity in two rodent models of rheumatoid arthritis. It also prevents splenomegaly and inhibits non-Hodgkin lymphoma tumor growth in a xenograft model.Suppliers and manufacturers
career henan chemical co
BOC Sciences
Hefei TNJ Chemical Industry Co.,Ltd.
LEAP CHEM CO., LTD.
Jilin Chinese Academy of Sciences-yanshen Technology
Aladdin Scientific
Amadis Chemical Company Limited
Shanghai Boyle Chemical Co., Ltd.
Shanghai Hanhong Scientific Co.,Ltd.
AdooQ BioScience, LLC
$7.00 /1KG
4-(3-(2H-1,2,3-Triazo-2-yl)phenylaMino)-2-((1R,2S)-2-aMinocyclohexylaMino) pyriMidine-5-carboxaMide CAS:1370261-96-3
4-(3-(2H-1,2,3-Triazo-2-yl)phenylaMino)-2-((1R,2S)-2-aMinocyclohexylaMino) pyriMidine-5-carboxaMide CAS:1370261-96-3