diABZI STING agonist-1 trihydrochloride
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- $158 - $1949.9
- Product name: diABZI STING agonist-1 trihydrochloride
- CAS: 2138299-34-8
- MF: C42H52ClN13O7
- MW: 886.41
- EINECS:
- MDL Number:MFCD31746912
- Synonyms:diABZI STING agonist-1 trihydrochloride;diABZI STING agonist-1;STING agonist-1（compound 3）trihydrochloride;STING?agonist?diABZ;(E)-1-(4-(5-Carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-benzo[d]imidazol-1-yl)but-2-en-1-yl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-7-methoxy-1H-benzimidazole-5-carboxamide tris(hydrochloride);diABZI STING Agonist 3 (hydrochloride);STING agonist-1 trihydrochloride;1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamide Hydrochloride (1:3)
13 prices
Selected condition：
Brand
- AK Scientific
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- DC Chemicals
- TRC
Package
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- ManufacturerAK Scientific
- Product number1582EN
- Product description1-[(E)-4-[5-Carbamoyl-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-(3-morpholin-4-ylpropoxy)benzimidazol-1-yl]but-2-enyl]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-methoxybenzimidazole-5-carboxamide;trihydrochloride
- Packaging1mg
- Price$430
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb572972
- Product descriptiondiABZI STING agonist-1 trihydrochloride >98%
- Packaging5mg
- Price$690.2
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb572972
- Product descriptiondiABZI STING agonist-1 trihydrochloride >98%
- Packaging10mg
- Price$1060.8
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb572972
- Product descriptiondiABZI STING agonist-1 trihydrochloride >98%
- Packaging25mg
- Price$1949.9
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number28054
- Product descriptiondiABZI STING Agonist 3 (hydrochloride)
- Packaging500μg
- Price$158
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28054
- Product descriptiondiABZI STING Agonist 3 (hydrochloride)
- Packaging1mg
- Price$299
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number28054
- Product descriptiondiABZI STING Agonist 3 (hydrochloride)
- Packaging5mg
- Price$743
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0077291
- Product descriptiondiABZISTINGagonist-1(trihydrochloride) 99.89%
- Packaging5mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0077291
- Product descriptiondiABZISTINGagonist-1(trihydrochloride) 99.89%
- Packaging10mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC12321
- Product descriptionSTINGagonist-1trihydrochloride >98%
- Packaging5mg
- Price$450
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC12321
- Product descriptionSTINGagonist-1trihydrochloride >98%
- Packaging10mg
- Price$700
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC12321
- Product descriptionSTINGagonist-1trihydrochloride >98%
- Packaging25mg
- Price$1300
- Updated2021-12-16
- Buy
- ManufacturerTRC
- Product numberA629825
- Product description1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamideHydrochloride(1:3)
- Packaging1mg
- Price$360
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 1582EN | 1-[(E)-4-[5-Carbamoyl-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-(3-morpholin-4-ylpropoxy)benzimidazol-1-yl]but-2-enyl]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]-7-methoxybenzimidazole-5-carboxamide;trihydrochloride | 1mg | $430 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb572972 | diABZI STING agonist-1 trihydrochloride >98% | 5mg | $690.2 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb572972 | diABZI STING agonist-1 trihydrochloride >98% | 10mg | $1060.8 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb572972 | diABZI STING agonist-1 trihydrochloride >98% | 25mg | $1949.9 | 2021-12-16 | Buy |
| Cayman Chemical | 28054 | diABZI STING Agonist 3 (hydrochloride) | 500μg | $158 | 2024-03-01 | Buy |
| Cayman Chemical | 28054 | diABZI STING Agonist 3 (hydrochloride) | 1mg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 28054 | diABZI STING Agonist 3 (hydrochloride) | 5mg | $743 | 2024-03-01 | Buy |
| ChemScene | CS-0077291 | diABZISTINGagonist-1(trihydrochloride) 99.89% | 5mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0077291 | diABZISTINGagonist-1(trihydrochloride) 99.89% | 10mg | $750 | 2021-12-16 | Buy |
| DC Chemicals | DC12321 | STINGagonist-1trihydrochloride >98% | 5mg | $450 | 2021-12-16 | Buy |
| DC Chemicals | DC12321 | STINGagonist-1trihydrochloride >98% | 10mg | $700 | 2021-12-16 | Buy |
| DC Chemicals | DC12321 | STINGagonist-1trihydrochloride >98% | 25mg | $1300 | 2021-12-16 | Buy |
| TRC | A629825 | 1-[(2E)-4-[5-(Aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-methoxy-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-[3-(4-morpholinyl)propoxy]-1H-benzimidazole-5-carboxamideHydrochloride(1:3) | 1mg | $360 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :DMSO: 50 mg/ml
form :A crystalline solid
color :White to yellow
InChIKey :PSJURLIZOBGEGB-HRNDJLQDSA-N
SMILES :C(N1C(=NC2=CC(C(=O)N)=CC(OCCCN3CCOCC3)=C12)NC(C1=CC(C)=NN1CC)=O)/C=C/CN1C(=NC2=CC(C(=O)N)=CC(OC)=C12)NC(C1=CC(C)=NN1CC)=O.Cl
solubility :DMSO: 50 mg/ml
form :A crystalline solid
color :White to yellow
InChIKey :PSJURLIZOBGEGB-HRNDJLQDSA-N
SMILES :C(N1C(=NC2=CC(C(=O)N)=CC(OCCCN3CCOCC3)=C12)NC(C1=CC(C)=NN1CC)=O)/C=C/CN1C(=NC2=CC(C(=O)N)=CC(OC)=C12)NC(C1=CC(C)=NN1CC)=O.Cl
Safety Information
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Description
diABZI STING agonist-1 is an agonist of the stimulator of interferon genes (STING) pathway. It induces secretion of IFN-β in human peripheral blood mononuclear cells (PBMCs; EC50 = 130 nM). diABZI STING agonist-1 (2.5 mg/kg) increases serum levels of IFN-β, IL-6, TNF, and KC/GROα in wild-type, but not Sting-/-, mice. It inhibits the cytopathic effect of the common cold human coronavirus 229E (HCoV-229E) in infected MRC-5 cells (EC50 = 3 nM). diABZI STING agonist-1 also decreases the level of severe acute respiratory coronavirus 2 (SARS-CoV-2) RNA in primary human bronchial airway epithelial cells in an air-liquid interface assay. It decreases tumor volume and increases survival in a CT26 murine colorectal cancer model when administered at a dose of 3 mg/kg.Suppliers and manufacturers
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