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ChemicalBook >> CAS DataBase List >> 2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one

2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one

2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one price.
  • $37 - $2242
  • Product name: 2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one
  • CAS: 2514-30-9
  • MF: C14H11NOS
  • MW: 241.31
  • EINECS:604-604-1
  • MDL Number:MFCD05856231
  • Synonyms:2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one;2-(4-Methylphenyl)-2,3-dihydrobenzisothiazol-3-one;2-p-Tolyl-1,2-benzisothiazolin-3-one;PBIT;PBIT, >=98%;JUMONJI HDM INHIBITOR;CS-1495;2-(4-methylphenyl)-1,2-benzothiazol-3-one
Price66 Properties Safety Information Description
66 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • ApexBio Technology
  • AvaChem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
  • Usbiological
Package
  • 10mM*1mLinDMSO
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 0.500g
  • 500.00mg
  • 1.00g
  • 1g
  • 10g
  • Manufactureraablocks
  • Product numberAA00BJGQ
  • Product description2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One ≥98%
  • Packaging1mg
  • Price$41
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BJGQ
  • Product description2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One
  • Packaging2mg
  • Price$56
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BJGQ
  • Product description2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One
  • Packaging5mg
  • Price$79
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BJGQ
  • Product description2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One
  • Packaging10mg
  • Price$111
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BJGQ
  • Product description2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One
  • Packaging25mg
  • Price$212
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BJGQ
  • Product description2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One
  • Packaging50mg
  • Price$323
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00BJGQ
  • Product description2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One
  • Packaging100mg
  • Price$510
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY226784
  • Product descriptionPBIT 97.00%
  • Packaging100MG
  • Price$730
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberY226784
  • Product descriptionPBIT 97.00%
  • Packaging25MG
  • Price$260
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberY1896
  • Product description2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one
  • Packaging25mg
  • Price$491
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3584
  • Product descriptionPBIT
  • Packaging25mg
  • Price$475
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3584
  • Product descriptionPBIT
  • Packaging25mg
  • Price$402
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3584
  • Product descriptionPBIT
  • Packaging10mg
  • Price$217
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3584
  • Product descriptionPBIT
  • Packaging10mg
  • Price$182
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3584
  • Product descriptionPBIT
  • Packaging5mg
  • Price$135
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberC3584
  • Product descriptionPBIT
  • Packaging5mg
  • Price$102
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00BJGQ 2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One ≥98% 1mg $41 2026-05-28 Buy
aablocks AA00BJGQ 2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One 2mg $56 2026-05-28 Buy
aablocks AA00BJGQ 2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One 5mg $79 2026-05-28 Buy
aablocks AA00BJGQ 2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One 10mg $111 2026-05-28 Buy
aablocks AA00BJGQ 2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One 25mg $212 2026-05-28 Buy
aablocks AA00BJGQ 2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One 50mg $323 2026-05-28 Buy
aablocks AA00BJGQ 2-(P-Tolyl)Benzo[D]Isothiazol-3(2H)-One 100mg $510 2026-05-28 Buy
ACHEMBLOCK Y226784 PBIT 97.00% 100MG $730 2026-05-27 Buy
ACHEMBLOCK Y226784 PBIT 97.00% 25MG $260 2026-05-27 Buy
AK Scientific Y1896 2-(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one 25mg $491 2021-12-16 Buy
ApexBio Technology C3584 PBIT 25mg $475 2026-05-06 Buy
ApexBio Technology C3584 PBIT 25mg $402 2021-12-16 Buy
ApexBio Technology C3584 PBIT 10mg $217 2026-05-06 Buy
ApexBio Technology C3584 PBIT 10mg $182 2021-12-16 Buy
ApexBio Technology C3584 PBIT 5mg $135 2026-05-06 Buy
ApexBio Technology C3584 PBIT 5mg $102 2021-12-16 Buy
Next Last

Properties

Melting point :136.7-137.1 °C(Solv: benzene (71-43-2); hexane (110-54-3))
Boiling point :418.2±38.0 °C(Predicted)
Density :1.297±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear (warmed)
pka :-0.03±0.20(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P501 Dispose of contents/container to..…

Description

Jumonji AT-rich interactive domain 1 (JARID1) demethylases mediate the removal of methyl groups from trimethylated lysine 4 on histone 3 (H3K4me3). PBIT is a reversible, cell-permeable inhibitor of JARID1 family demethylases (IC50s = 6, 3, 4.9, and 28 μM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively). It does not significantly affect the activity of UTX and JMJD3 demethylases. It increases trimethylation of H3K4 in HeLa cells and blocks the proliferation of tumor cells expressing high levels of JARID1B.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
PBIT
$32.00
PBIT CAS:2514-30-9
Shaanxi Dideu New Materials Co. Ltd
2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one
2 - (4 - Methylphenyl) - 1,2 - benzisothiazol - 3(2H)-one CAS:2514-30-9
ATK CHEMICAL COMPANY LIMITED
Career Henan Chemica Co
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Wuhan Han Sheng New Material Technology Co.，Ltd
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
Aladdin Scientific
NANJING YINGWEN BIOTECHNOLOGY CO LTD