Canertinib dihydrochloride
|
- $16 - $7103.25
- Product name: Canertinib dihydrochloride
- CAS: 289499-45-2
- MF: C24H27Cl3FN5O3
- MW: 558.86
- EINECS:
- MDL Number:MFCD09954112
- Synonyms:CANERTINIB DIHYDROCHLORIDE;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride;Canertinib.2HCL;CI-1033;N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride;Canertinib HCl;CI 103
64 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 50.00mg
- 100mg
- 100.00mg
- 250mg
- 250.00mg
- 500mg
- 1G
- 25
- 5G
- 10mM*1mLinDMSO
- Manufactureraablocks
- Product numberAA002X3K
- Product descriptionCanertinib dihydrochloride 99%
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002X3K
- Product descriptionCanertinib dihydrochloride ≥98%(HPLC)
- Packaging5mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002X3K
- Product descriptionCanertinib dihydrochloride 99%
- Packaging10mg
- Price$32
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002X3K
- Product descriptionCanertinib dihydrochloride 99%
- Packaging50mg
- Price$45
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002X3K
- Product descriptionCanertinib dihydrochloride 99%
- Packaging100mg
- Price$70
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002X3K
- Product descriptionCanertinib dihydrochloride 99%
- Packaging250mg
- Price$150
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberS86740
- Product descriptionCanertinib dihydrochloride 98%
- Packaging100MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS86740
- Product descriptionCanertinib dihydrochloride 98%
- Packaging1G
- Price$595
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS86740
- Product descriptionCanertinib dihydrochloride 98%
- Packaging5G
- Price$2380
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3516AH
- Product descriptionCanertinibdihydrochloride
- Packaging5mg
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3516AH
- Product descriptionCanertinibdihydrochloride
- Packaging10mg
- Price$109
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging50mg
- Price$86
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging100mg
- Price$111
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging10mg
- Price$51
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging5mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA239262
- Product descriptionCanertinibdihydrochloride 98+%
- Packaging250mg
- Price$189
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA002X3K | Canertinib dihydrochloride 99% | 1mg | $16 | 2026-05-28 | Buy |
| aablocks | AA002X3K | Canertinib dihydrochloride ≥98%(HPLC) | 5mg | $29 | 2026-05-28 | Buy |
| aablocks | AA002X3K | Canertinib dihydrochloride 99% | 10mg | $32 | 2026-05-28 | Buy |
| aablocks | AA002X3K | Canertinib dihydrochloride 99% | 50mg | $45 | 2026-05-28 | Buy |
| aablocks | AA002X3K | Canertinib dihydrochloride 99% | 100mg | $70 | 2026-05-28 | Buy |
| aablocks | AA002X3K | Canertinib dihydrochloride 99% | 250mg | $150 | 2026-05-28 | Buy |
| ACHEMBLOCK | S86740 | Canertinib dihydrochloride 98% | 100MG | $110 | 2026-05-27 | Buy |
| ACHEMBLOCK | S86740 | Canertinib dihydrochloride 98% | 1G | $595 | 2026-05-27 | Buy |
| ACHEMBLOCK | S86740 | Canertinib dihydrochloride 98% | 5G | $2380 | 2026-05-27 | Buy |
| AK Scientific | 3516AH | Canertinibdihydrochloride | 5mg | $95 | 2021-12-16 | Buy |
| AK Scientific | 3516AH | Canertinibdihydrochloride | 10mg | $109 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 50mg | $86 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 100mg | $111 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 10mg | $51 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 5mg | $40 | 2021-12-16 | Buy |
| Ambeed | A239262 | Canertinibdihydrochloride 98+% | 250mg | $189 | 2021-12-16 | Buy |
Properties
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: >10mg/mL
form :solid
color :Light yellow to green yellow
InChIKey :JZZFDCXSFTVOJY-UHFFFAOYSA-N
SMILES :Cl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
solubility :DMSO: >10mg/mL
form :solid
color :Light yellow to green yellow
InChIKey :JZZFDCXSFTVOJY-UHFFFAOYSA-N
SMILES :Cl.Cl.Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
The HER family of receptor tyrosine kinases, EGFR, HER2, HER3, and HER4, mediate proliferation, migration, adhesion, differentiation, and survival in many different cell types and have been implicated in the development and progression of a variety of human tumors. Canertinib is an irreversible quinazoline-based HER family tyrosine kinase inhibitor with IC50 values of 0.8, 19, and 7 nM for blocking in vitro activity of EGFR, HER2, and HER4, respectively. As a broadly applicable anti-cancer agent, it has been used to suppress proliferation of malignant peripheral nerve sheath tumor cells (effective concentration of 250-500 nM), to inhibit growth and induce dose-dependent apoptosis in a panel of neuroblastoma cell lines (IC50s = 0.94-2.45 μM), and to reduce proliferation of acute myeloid leukemia cells (IC50 = 0.27 μM). Canertinib also displays anti-neoplastic activity towards T98G glioblastoma cells, HCT8 colorectal carcinoma cells, and cells expressing the breast cancer resistance protein.More related product prices
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