3-deazaneplanocin
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- $107 - $4800
- Product name: 3-deazaneplanocin
- CAS: 102052-95-9
- MF: C12H14N4O3
- MW: 262.26
- EINECS:
- MDL Number:MFCD12545899
- Synonyms:3-deazaneplanocin;NSC 617989 3-deazaneplanocin(DzNep);3-Cyclopentene-1,2-diol,5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-, (1S,2R,5R)-;(1R,4R,5S)-4-(5-amino-4,7,9-triazabicyclo[4.3.0]nona-2,4,7,10-tetraen-9-yl)-2-(hydroxymethyl)cyclopent-2-ene-1,5-diol;(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol;3-deazaneplanocin(DzNep);NSC 617989;(1S,2R,5R)-5-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol
40 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Usbiological
Package
- 500μg
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250MG
- 1G
- 5G
- Manufactureraablocks
- Product numberAA0006ED
- Product description(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol 98%
- Packaging1mg
- Price$228
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0006ED
- Product description(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol 98%
- Packaging5mg
- Price$565
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0006ED
- Product description(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol 98%
- Packaging10mg
- Price$785
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0006ED
- Product description(1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol 98%
- Packaging25mg
- Price$1159
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD265218
- Product description3-Deazaneplanocin A 98%
- Packaging25MG
- Price$400
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberAD265218
- Product description3-Deazaneplanocin A 98%
- Packaging5MG
- Price$125
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3238AH
- Product description3-Deazaneplanocin
- Packaging5mg
- Price$633
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number3238AH
- Product description3-Deazaneplanocin
- Packaging10mg
- Price$868
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0167538
- Product description3-DEAZANEPLANOCIN 95.00%
- Packaging250MG
- Price$1034.88
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0167538
- Product description3-DEAZANEPLANOCIN 95.00%
- Packaging1G
- Price$1566.18
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0167538
- Product description3-DEAZANEPLANOCIN 95.00%
- Packaging5G
- Price$3402.63
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA1905
- Product description3-Deazaneplanocin,DZNep
- Packaging10mg
- Price$596
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1905
- Product description3-Deazaneplanocin,DZNep
- Packaging25mg
- Price$895
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1905
- Product description3-Deazaneplanocin,DZNep
- Packaging1mg
- Price$150
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA1905
- Product description3-Deazaneplanocin,DZNep
- Packaging5mg
- Price$420
- Updated2026-05-06
- Buy
- ManufacturerAvaChem
- Product number6956
- Product descriptionDZNep >98%
- Packaging1mg
- Price$142
- Updated2026-05-22
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0006ED | (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol 98% | 1mg | $228 | 2026-05-25 | Buy |
| aablocks | AA0006ED | (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol 98% | 5mg | $565 | 2026-05-25 | Buy |
| aablocks | AA0006ED | (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol 98% | 10mg | $785 | 2026-05-25 | Buy |
| aablocks | AA0006ED | (1S,2R,5R)-5-(4-Amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1,2-diol 98% | 25mg | $1159 | 2026-05-25 | Buy |
| ACHEMBLOCK | AD265218 | 3-Deazaneplanocin A 98% | 25MG | $400 | 2026-05-27 | Buy |
| ACHEMBLOCK | AD265218 | 3-Deazaneplanocin A 98% | 5MG | $125 | 2026-05-27 | Buy |
| AK Scientific | 3238AH | 3-Deazaneplanocin | 5mg | $633 | 2021-12-16 | Buy |
| AK Scientific | 3238AH | 3-Deazaneplanocin | 10mg | $868 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0167538 | 3-DEAZANEPLANOCIN 95.00% | 250MG | $1034.88 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0167538 | 3-DEAZANEPLANOCIN 95.00% | 1G | $1566.18 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0167538 | 3-DEAZANEPLANOCIN 95.00% | 5G | $3402.63 | 2021-12-16 | Buy |
| ApexBio Technology | A1905 | 3-Deazaneplanocin,DZNep | 10mg | $596 | 2026-05-06 | Buy |
| ApexBio Technology | A1905 | 3-Deazaneplanocin,DZNep | 25mg | $895 | 2026-05-06 | Buy |
| ApexBio Technology | A1905 | 3-Deazaneplanocin,DZNep | 1mg | $150 | 2026-05-06 | Buy |
| ApexBio Technology | A1905 | 3-Deazaneplanocin,DZNep | 5mg | $420 | 2026-05-06 | Buy |
| AvaChem | 6956 | DZNep >98% | 1mg | $142 | 2026-05-22 | Buy |
Properties
Boiling point :624.1±65.0 °C(Predicted)
Density :1.75
storage temp. := -70C
solubility :Soluble in DMSO (up to 20 mg/ml)
form :Liquid
pka :13.52±0.70(Predicted)
color :Beige
Water Solubility :Soluble in Water
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1
InChIKey :OMKHWTRUYNAGFG-IEBDPFPHSA-N
SMILES :[C@H]1(O)[C@H](N2C3C=CN=C(N)C=3N=C2)C=C(CO)[C@H]1O
Density :1.75
storage temp. := -70C
solubility :Soluble in DMSO (up to 20 mg/ml)
form :Liquid
pka :13.52±0.70(Predicted)
color :Beige
Water Solubility :Soluble in Water
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C12H14N4O3/c13-12-9-7(1-2-14-12)16(5-15-9)8-3-6(4-17)10(18)11(8)19/h1-3,5,8,10-11,17-19H,4H2,(H2,13,14)/t8-,10-,11+/m1/s1
InChIKey :OMKHWTRUYNAGFG-IEBDPFPHSA-N
SMILES :[C@H]1(O)[C@H](N2C3C=CN=C(N)C=3N=C2)C=C(CO)[C@H]1O
Safety Information
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Description
The lysine methyltransferase EZH2 (KMT6), part of the polycomb repressive complex 2, catalyzes trimethylation of lysine 27 on histone H3 and is involved in proliferation and aggressive cell growth associated with neoplastic cells. 3-Deazaneplanocin A is a cyclopentenyl analog of 3-deazaadenosine, originally synthesized as an inhibitor of S-adenosyl-L-homocysteine hydrolase. It has been shown to deplete EZH2 levels and to inhibit trimethylation of lysine 27 on histone H3 in cultured human acute myeloid leukemia (AML) HL-60 and OCI-AML3 cells and in primary AML cells in a dose-dependent manner (0.2-1 μM). 3-Deazaneplanocin A treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis. When used in combination with the pan-histone deacetylase inhibitor panobinostat (10 mg/kg), 3-deazaneplanocin A’s (1 mg/kg) antileukemic effects are synergistically enhanced in mice implanted with AML cells.Related product price
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