HPI-4,Hedgehog Pathway Inhibitor 4
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- $51 - $1800
- Product name: HPI-4,Hedgehog Pathway Inhibitor 4
- CAS: 302803-72-1
- MF: C17H9Cl2N3O2
- MW: 358.18
- EINECS:687-330-4
- MDL Number:MFCD01911757
- Synonyms:HPI-4;HPI-4,Hedgehog Pathway Inhibitor 4;Ciliobrevin A;Ciliobrevin A(HPI4);2,4-Dichloro-a-(3,4-dihydro-4-oxo-2(1H)-quinazolinylidene)-β-oxo-benzenepropanenitrile;Hedgehog Pathway Inhibitor 4;2-(7-Chloro-4-oxo-3,4-dihydro-1H-quinazolin-2-ylidene)-3-(2,4-dichloro-phenyl)-3-oxo-propionitrile;(Z)-3-(2,4-dichlorophenyl)-3-oxo-2-(4-oxo-3,4-dihydroquinazolin-2(1H)-ylidene)propanenitrile
30 prices
Selected condition：
Brand
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 25
- 5mg
- 5
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAmbeed
- Product numberA766712
- Product descriptionCiliobrevinA 98+%
- Packaging5mg
- Price$51
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA766712
- Product descriptionCiliobrevinA 98+%
- Packaging10mg
- Price$67
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA766712
- Product descriptionCiliobrevinA 98+%
- Packaging25mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA766712
- Product descriptionCiliobrevinA 98+%
- Packaging50mg
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0000848
- Product descriptionHPI-4 95.00%
- Packaging25MG
- Price$928.97
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8655
- Product descriptionCiliobrevinA
- Packaging5mg
- Price$91
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8655
- Product descriptionCiliobrevinA
- Packaging10mg
- Price$122
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8655
- Product descriptionCiliobrevinA
- Packaging25mg
- Price$268
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8655
- Product descriptionCiliobrevinA
- Packaging50mg
- Price$488
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number22587
- Product descriptionCiliobrevin A ≥98%
- Packaging5mg
- Price$68
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22587
- Product descriptionCiliobrevin A ≥98%
- Packaging10mg
- Price$109
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22587
- Product descriptionCiliobrevin A ≥98%
- Packaging25mg
- Price$252
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number22587
- Product descriptionCiliobrevin A ≥98%
- Packaging50mg
- Price$469
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-6016
- Product descriptionCiliobrevinA 98.72%
- Packaging5mg
- Price$72
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6016
- Product descriptionCiliobrevinA 98.72%
- Packaging10mg
- Price$96
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-6016
- Product descriptionCiliobrevinA 98.72%
- Packaging25mg
- Price$216
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Ambeed | A766712 | CiliobrevinA 98+% | 5mg | $51 | 2021-12-16 | Buy |
| Ambeed | A766712 | CiliobrevinA 98+% | 10mg | $67 | 2021-12-16 | Buy |
| Ambeed | A766712 | CiliobrevinA 98+% | 25mg | $88 | 2021-12-16 | Buy |
| Ambeed | A766712 | CiliobrevinA 98+% | 50mg | $115 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000848 | HPI-4 95.00% | 25MG | $928.97 | 2021-12-16 | Buy |
| ApexBio Technology | A8655 | CiliobrevinA | 5mg | $91 | 2021-12-16 | Buy |
| ApexBio Technology | A8655 | CiliobrevinA | 10mg | $122 | 2021-12-16 | Buy |
| ApexBio Technology | A8655 | CiliobrevinA | 25mg | $268 | 2021-12-16 | Buy |
| ApexBio Technology | A8655 | CiliobrevinA | 50mg | $488 | 2021-12-16 | Buy |
| Cayman Chemical | 22587 | Ciliobrevin A ≥98% | 5mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 22587 | Ciliobrevin A ≥98% | 10mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 22587 | Ciliobrevin A ≥98% | 25mg | $252 | 2024-03-01 | Buy |
| Cayman Chemical | 22587 | Ciliobrevin A ≥98% | 50mg | $469 | 2024-03-01 | Buy |
| ChemScene | CS-6016 | CiliobrevinA 98.72% | 5mg | $72 | 2021-12-16 | Buy |
| ChemScene | CS-6016 | CiliobrevinA 98.72% | 10mg | $96 | 2021-12-16 | Buy |
| ChemScene | CS-6016 | CiliobrevinA 98.72% | 25mg | $216 | 2021-12-16 | Buy |
Properties
Boiling point :564.5±50.0 °C(Predicted)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :6.46±0.20(Predicted)
form :powder
color :off-white, off-white to orange
InChI :1S/C17H9Cl2N3O2/c18-9-5-6-10(13(19)7-9)15(23)12(8-20)16-21-14-4-2-1-3-11(14)17(24)22-16/h1-7,21H,(H,22,24)/b16-12+
InChIKey :SESYPWCSIZUIAS-FOWTUZBSSA-N
SMILES :Clc1ccc(c(Cl)c1)C(=O)\C(C#N)=C2\NC(=O)c3ccccc3N2
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :6.46±0.20(Predicted)
form :powder
color :off-white, off-white to orange
InChI :1S/C17H9Cl2N3O2/c18-9-5-6-10(13(19)7-9)15(23)12(8-20)16-21-14-4-2-1-3-11(14)17(24)22-16/h1-7,21H,(H,22,24)/b16-12+
InChIKey :SESYPWCSIZUIAS-FOWTUZBSSA-N
SMILES :Clc1ccc(c(Cl)c1)C(=O)\C(C#N)=C2\NC(=O)c3ccccc3N2
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Ciliobrevin A is a hedgehog pathway inhibitor that blocks sonic hedgehog (Shh)-induced hedgehog pathway activation (IC50 = 7 μM). It disrupts primary cilia formation and inhibits the dynein-dependent microtubial gliding and ATPase activities of the cytoplasmic ATPases associated with various cellular activities (AAA+) family. Ciliobrevin A also inhibits mammalian target of rapamycin complex 1 (mTORC1) activity in uninfected and human cytomegalovirus (HCMV)-infected cells, suggesting that mTORC1 activation requires dynein-dependent transport for cellular activation.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
HANGZHOU LEAP CHEM CO., LTD.
Hangzhou MolCore BioPharmatech Co.,Ltd.
TargetMol Chemicals Inc.
