4-Hydroxyquinazoline
|
- $5 - $1755
- Product name: 4-Hydroxyquinazoline
- CAS: 491-36-1
- MF: C8H6N2O
- MW: 146.15
- EINECS:207-735-8
- MDL Number:MFCD00511302
- Synonyms:4(3H)-Quinazolone;4-Quinazolinone;Quinazolone, 4-;quinazolidin-4-one;1H-quinazolin-4-one;TIMTEC-BB SBB005858;AURORA 17795;4-HYDROXYQUINAZOLINE
101 prices
Selected condition：
Brand
- aablocks
- Acrotein
- Activate Scientific
- AK Scientific
- Alichem
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Atlantic Research Chemicals
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Frontier Specialty Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- SynQuest Laboratories
- Synthonix
- TCI Chemical
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 5MG
- 20mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 500.00mg
- 10mM*1mLinDMSO(Solution)
- 1g
- 2.5g
- 5g
- 10g
- 25g
- 50g
- 100g
- 250g
- 0.5kg
- 500g
- 1kg
- 2kg
- 10mM(in1mLDMSO)
- 10kg
- 2.5kg
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one 95%
- Packaging5g
- Price$9
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one 95%
- Packaging10g
- Price$11
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one 95%
- Packaging25g
- Price$13
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one 95%
- Packaging100g
- Price$38
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one ≥98%(HPLC)
- Packaging500g
- Price$123
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberAS00634
- Product description4-Hydroxyquinazoline 97%
- Packaging500g
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerAcrotein
- Product numberAS00634
- Product description4-Hydroxyquinazoline 97%
- Packaging500g
- Price$220
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberAS00634
- Product description4-Hydroxyquinazoline 97%
- Packaging250g
- Price$128.34
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberAS00634
- Product description4-Hydroxyquinazoline 97%
- Packaging100g
- Price$64.16
- Updated2026-05-25
- Buy
- ManufacturerActivate Scientific
- Product numberAS20007
- Product description4-Hydroxyquinazoline 98%
- Packaging100g
- Price$93
- Updated2026-06-04
- Buy
- ManufacturerActivate Scientific
- Product numberAS20007
- Product description4-Hydroxyquinazoline 98%
- Packaging25g
- Price$40
- Updated2026-06-04
- Buy
- ManufacturerActivate Scientific
- Product numberAS20007
- Product description4-Hydroxyquinazoline 98%
- Packaging5g
- Price$20
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ53357
- Product description4-Hydroxyquinazoline
- Packaging25g
- Price$23
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberI302
- Product description4-Hydroxyquinazoline 98%
- Packaging25g
- Price$23
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberI302
- Product description4-Hydroxyquinazoline 98%
- Packaging5g
- Price$16
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ53357
- Product description4-Hydroxyquinazoline 95%
- Packaging25g
- Price$17
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0010G5 | Quinazolin-4(3H)-one 95% | 5g | $9 | 2026-05-25 | Buy |
| aablocks | AA0010G5 | Quinazolin-4(3H)-one 95% | 10g | $11 | 2026-05-25 | Buy |
| aablocks | AA0010G5 | Quinazolin-4(3H)-one 95% | 25g | $13 | 2026-05-25 | Buy |
| aablocks | AA0010G5 | Quinazolin-4(3H)-one 95% | 100g | $38 | 2026-05-25 | Buy |
| aablocks | AA0010G5 | Quinazolin-4(3H)-one ≥98%(HPLC) | 500g | $123 | 2026-05-25 | Buy |
| Acrotein | AS00634 | 4-Hydroxyquinazoline 97% | 500g | $220 | 2021-12-16 | Buy |
| Acrotein | AS00634 | 4-Hydroxyquinazoline 97% | 500g | $220 | 2026-05-25 | Buy |
| Acrotein | AS00634 | 4-Hydroxyquinazoline 97% | 250g | $128.34 | 2026-05-25 | Buy |
| Acrotein | AS00634 | 4-Hydroxyquinazoline 97% | 100g | $64.16 | 2026-05-25 | Buy |
| Activate Scientific | AS20007 | 4-Hydroxyquinazoline 98% | 100g | $93 | 2026-06-04 | Buy |
| Activate Scientific | AS20007 | 4-Hydroxyquinazoline 98% | 25g | $40 | 2026-06-04 | Buy |
| Activate Scientific | AS20007 | 4-Hydroxyquinazoline 98% | 5g | $20 | 2026-06-04 | Buy |
| AK Scientific | J53357 | 4-Hydroxyquinazoline | 25g | $23 | 2021-12-16 | Buy |
| AK Scientific | I302 | 4-Hydroxyquinazoline 98% | 25g | $23 | 2026-06-04 | Buy |
| AK Scientific | I302 | 4-Hydroxyquinazoline 98% | 5g | $16 | 2026-06-04 | Buy |
| AK Scientific | J53357 | 4-Hydroxyquinazoline 95% | 25g | $17 | 2026-06-04 | Buy |
Properties
Melting point :216-219 °C (lit.)
Boiling point :265.75°C (rough estimate)
Density :1.2312 (rough estimate)
vapor pressure :0.015Pa at 20℃
refractive index :1.4900 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
form :Crystalline Powder
pka :2.69±0.20(Predicted)
color :Off-white to light beige
Water Solubility :Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Sensitive :Hygroscopic
BRN :118473
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChI :1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
InChIKey :QMNUDYFKZYBWQX-UHFFFAOYSA-N
SMILES :O=C1NC=Nc2ccccc12
LogP :0.94 at 20℃
CAS DataBase Reference :491-36-1(CAS DataBase Reference)
NIST Chemistry Reference :4(1H)-quinazolinone(491-36-1)
Boiling point :265.75°C (rough estimate)
Density :1.2312 (rough estimate)
vapor pressure :0.015Pa at 20℃
refractive index :1.4900 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
form :Crystalline Powder
pka :2.69±0.20(Predicted)
color :Off-white to light beige
Water Solubility :Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Sensitive :Hygroscopic
BRN :118473
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChI :1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
InChIKey :QMNUDYFKZYBWQX-UHFFFAOYSA-N
SMILES :O=C1NC=Nc2ccccc12
LogP :0.94 at 20℃
CAS DataBase Reference :491-36-1(CAS DataBase Reference)
NIST Chemistry Reference :4(1H)-quinazolinone(491-36-1)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.Related product price
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Suppliers and manufacturers
Henan Fengda Chemical Co., Ltd
Capot Chemical Co.,Ltd.
JingJiang Connect Chemical manufacturing Co., Ltd.
Alchem Pharmtech,Inc.
CONIER CHEM AND PHARMA LIMITED
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
SIMAGCHEM CORP
Wuhan ChemNorm Biotech Co.,Ltd.
4-Hydroxyquinazoline
CAS:491-36-1
