4-Hydroxyquinazoline
|
- $5 - $1755
- Product name: 4-Hydroxyquinazoline
- CAS: 491-36-1
- MF: C8H6N2O
- MW: 146.15
- EINECS:207-735-8
- MDL Number:MFCD00511302
- Synonyms:4(3H)-Quinazolone;4-Quinazolinone;Quinazolone, 4-;quinazolidin-4-one;1H-quinazolin-4-one;TIMTEC-BB SBB005858;AURORA 17795;4-HYDROXYQUINAZOLINE
87 prices
Selected condition：
Brand
- aablocks
- Acrotein
- Activate Scientific
- AK Scientific
- Alichem
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Atlantic Research Chemicals
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- Chem-Impex
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Frontier Specialty Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- SynQuest Laboratories
- Synthonix
- TCI Chemical
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 5MG
- 20mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 500.00mg
- 10mM*1mLinDMSO(Solution)
- 1g
- 2.5g
- 5g
- 10g
- 25g
- 50g
- 100g
- 250g
- 0.5kg
- 500g
- 1kg
- 2kg
- 10mM(in1mLDMSO)
- 10kg
- 2.5kg
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one 95%
- Packaging5g
- Price$9
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one 95%
- Packaging10g
- Price$11
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one 95%
- Packaging25g
- Price$13
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one 95%
- Packaging100g
- Price$38
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA0010G5
- Product descriptionQuinazolin-4(3H)-one ≥98%(HPLC)
- Packaging500g
- Price$123
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberAS00634
- Product description4-Hydroxyquinazoline 97%
- Packaging100g
- Price$64.16
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberAS00634
- Product description4-Hydroxyquinazoline 97%
- Packaging250g
- Price$128.34
- Updated2026-05-25
- Buy
- ManufacturerAcrotein
- Product numberAS00634
- Product description4-Hydroxyquinazoline 97%
- Packaging500g
- Price$220
- Updated2026-05-25
- Buy
- ManufacturerActivate Scientific
- Product numberAS20007
- Product description4-Hydroxyquinazoline 98%
- Packaging25g
- Price$40
- Updated2026-06-04
- Buy
- ManufacturerActivate Scientific
- Product numberAS20007
- Product description4-Hydroxyquinazoline 98%
- Packaging100g
- Price$93
- Updated2026-06-04
- Buy
- ManufacturerActivate Scientific
- Product numberAS20007
- Product description4-Hydroxyquinazoline 98%
- Packaging5g
- Price$20
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberI302
- Product description4-Hydroxyquinazoline 98%
- Packaging25g
- Price$23
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberI302
- Product description4-Hydroxyquinazoline 98%
- Packaging5g
- Price$16
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ53357
- Product description4-Hydroxyquinazoline 95%
- Packaging25g
- Price$17
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ53357
- Product description4-Hydroxyquinazoline 95%
- Packaging5g
- Price$12
- Updated2026-06-04
- Buy
- ManufacturerAK Scientific
- Product numberJ53357
- Product description4-Hydroxyquinazoline 95%
- Packaging100g
- Price$41
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0010G5 | Quinazolin-4(3H)-one 95% | 5g | $9 | 2026-05-25 | Buy |
| aablocks | AA0010G5 | Quinazolin-4(3H)-one 95% | 10g | $11 | 2026-05-25 | Buy |
| aablocks | AA0010G5 | Quinazolin-4(3H)-one 95% | 25g | $13 | 2026-05-25 | Buy |
| aablocks | AA0010G5 | Quinazolin-4(3H)-one 95% | 100g | $38 | 2026-05-25 | Buy |
| aablocks | AA0010G5 | Quinazolin-4(3H)-one ≥98%(HPLC) | 500g | $123 | 2026-05-25 | Buy |
| Acrotein | AS00634 | 4-Hydroxyquinazoline 97% | 100g | $64.16 | 2026-05-25 | Buy |
| Acrotein | AS00634 | 4-Hydroxyquinazoline 97% | 250g | $128.34 | 2026-05-25 | Buy |
| Acrotein | AS00634 | 4-Hydroxyquinazoline 97% | 500g | $220 | 2026-05-25 | Buy |
| Activate Scientific | AS20007 | 4-Hydroxyquinazoline 98% | 25g | $40 | 2026-06-04 | Buy |
| Activate Scientific | AS20007 | 4-Hydroxyquinazoline 98% | 100g | $93 | 2026-06-04 | Buy |
| Activate Scientific | AS20007 | 4-Hydroxyquinazoline 98% | 5g | $20 | 2026-06-04 | Buy |
| AK Scientific | I302 | 4-Hydroxyquinazoline 98% | 25g | $23 | 2026-06-04 | Buy |
| AK Scientific | I302 | 4-Hydroxyquinazoline 98% | 5g | $16 | 2026-06-04 | Buy |
| AK Scientific | J53357 | 4-Hydroxyquinazoline 95% | 25g | $17 | 2026-06-04 | Buy |
| AK Scientific | J53357 | 4-Hydroxyquinazoline 95% | 5g | $12 | 2026-06-04 | Buy |
| AK Scientific | J53357 | 4-Hydroxyquinazoline 95% | 100g | $41 | 2026-06-04 | Buy |
Properties
Melting point :216-219 °C (lit.)
Boiling point :265.75°C (rough estimate)
Density :1.2312 (rough estimate)
vapor pressure :0.015Pa at 20℃
refractive index :1.4900 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
form :Crystalline Powder
pka :2.69±0.20(Predicted)
color :Off-white to light beige
Water Solubility :Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Sensitive :Hygroscopic
BRN :118473
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChI :1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
InChIKey :QMNUDYFKZYBWQX-UHFFFAOYSA-N
SMILES :O=C1NC=Nc2ccccc12
LogP :0.94 at 20℃
CAS DataBase Reference :491-36-1(CAS DataBase Reference)
NIST Chemistry Reference :4(1H)-quinazolinone(491-36-1)
Boiling point :265.75°C (rough estimate)
Density :1.2312 (rough estimate)
vapor pressure :0.015Pa at 20℃
refractive index :1.4900 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :Soluble in DMSO (up to 14 mg/ml) or in Water (up to 1 mg/ml).
form :Crystalline Powder
pka :2.69±0.20(Predicted)
color :Off-white to light beige
Water Solubility :Soluble in DMSO (100 mM), ethanol, methanol, and water (10 mM).
Sensitive :Hygroscopic
BRN :118473
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
InChI :1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)
InChIKey :QMNUDYFKZYBWQX-UHFFFAOYSA-N
SMILES :O=C1NC=Nc2ccccc12
LogP :0.94 at 20℃
CAS DataBase Reference :491-36-1(CAS DataBase Reference)
NIST Chemistry Reference :4(1H)-quinazolinone(491-36-1)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period.Related product price
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