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ChemicalBook >> CAS DataBase List >> (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE price.
  • $36 - $560
  • Product name: (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE
  • CAS: 451462-58-1
  • MF: C16H21N3O2S
  • MW: 319.42
  • EINECS:
  • MDL Number:MFCD07357272
  • Synonyms:(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepinedihydrochloride;H1152;H1152P;(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE;(S)-H-1152 (hydrochloride);(S)-H-1152 dihydrochloride;H-1152;H 1152;H1152;4-methyl-5-[(2-methyl-1,4-diazepan-1-yl)sulfonyl]isoquinoline,dihydrochloride
Price10 Properties Safety Information Description
10 prices
Selected condition：
Brand
  • ACHEMBLOCK
  • AK Scientific
  • Cayman Chemical
  • Crysdot
  • CSNpharm
Package
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 25MG
  • ManufacturerACHEMBLOCK
  • Product numberH-8963
  • Product description(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine 98%
  • Packaging25MG
  • Price$235
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number3714AH
  • Product description(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline
  • Packaging5mg
  • Price$402
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10007653
  • Product description(S)-H-1152 (hydrochloride) ≥95%
  • Packaging500μg
  • Price$36
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10007653
  • Product description(S)-H-1152 (hydrochloride) ≥95%
  • Packaging1mg
  • Price$66
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10007653
  • Product description(S)-H-1152 (hydrochloride) ≥95%
  • Packaging5mg
  • Price$274
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10007653
  • Product description(S)-H-1152 (hydrochloride) ≥95%
  • Packaging10mg
  • Price$477
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001869
  • Product descriptionH-1152 98+%
  • Packaging10mg
  • Price$315
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001869
  • Product descriptionH-1152 98+%
  • Packaging25mg
  • Price$560
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN16493
  • Product descriptionH-1152
  • Packaging1mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerCSNpharm
  • Product numberCSN16493
  • Product descriptionH-1152
  • Packaging10mg
  • Price$303
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ACHEMBLOCK H-8963 (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolynyl)sulfonyl]homopiperazine 98% 25MG $235 2021-12-16 Buy
AK Scientific 3714AH (S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline 5mg $402 2021-12-16 Buy
Cayman Chemical 10007653 (S)-H-1152 (hydrochloride) ≥95% 500μg $36 2024-03-01 Buy
Cayman Chemical 10007653 (S)-H-1152 (hydrochloride) ≥95% 1mg $66 2024-03-01 Buy
Cayman Chemical 10007653 (S)-H-1152 (hydrochloride) ≥95% 5mg $274 2024-03-01 Buy
Cayman Chemical 10007653 (S)-H-1152 (hydrochloride) ≥95% 10mg $477 2024-03-01 Buy
Crysdot CD31001869 H-1152 98+% 10mg $315 2021-12-16 Buy
Crysdot CD31001869 H-1152 98+% 25mg $560 2021-12-16 Buy
CSNpharm CSN16493 H-1152 1mg $72 2021-12-16 Buy
CSNpharm CSN16493 H-1152 10mg $303 2021-12-16 Buy

Properties

Boiling point :519.6±60.0 °C(Predicted)
Density :1.218±0.06 g/cm3(Predicted)
storage temp. :Desiccate at +4°C
solubility :25℃: DMSO
form :Powder
pka :9.76±0.40(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

H-1152 . dihydrochloride is a selective ATP-competitive inhibitor of rho-kinase (ROCK) inhibitor, cell permeable, highly specific, and potent (Ki = 1.6 nM). Exhibits weaker affinity for other serine/threonine kinases (Ki = 630 nM for PKA, 9.27mM for PKC and 10.1 mM for MLCK) and is more potent and selective than Y-27632. Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid and inhibits EP3-stimulated NO formation. H-1152 . dihydrochloride prevents fragmentation of apoptotic cells. Relieves neuropathic pain.

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Suppliers and manufacturers

Hangzhou MolCore BioPharmatech Co.,Ltd.
TargetMol Chemicals Inc.
Aladdin Scientific Shanghai Boyle Chemical Co., Ltd. 3B Pharmachem (Wuhan) International Co.,Ltd. VDM Biochemicals AdooQ BioScience, LLC Sichuan Wei Keqi Biological Technology Co., Ltd. ShangHai KenEn Chemical Technology Co., Ltd. AdooQ Bioscience CHINA