cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid
![cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid price.](/CAS/GIF/471905-41-6.gif)
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- $28 - $2700
- Product name: cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid
- CAS: 471905-41-6
- MF: C21H21ClF2O4S
- MW: 442.9
- EINECS:
- MDL Number:MFCD21608529
- Synonyms:MK-0752, >=98%;Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-;MK-0752/MK0752;3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid MK-0752;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid;CS-10
26 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Labseeker
- Matrix Scientific
- Medical Isotopes, Inc.
Package
- 10mg
- 50mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- 1MG
- 1unit
- 5MG
- 100mg
- ManufacturerAK Scientific
- Product numberX7591
- Product description3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoicacid
- Packaging100mg
- Price$2431
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004452
- Product descriptionMK-0752 95.00%
- Packaging1MG
- Price$173.25
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004452
- Product descriptionMK-0752 95.00%
- Packaging5MG
- Price$500.15
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4006
- Product descriptionMK-0752
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4006
- Product descriptionMK-0752
- Packaging5mg
- Price$170
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4006
- Product descriptionMK-0752
- Packaging10mM(in 1mL DMSO)
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4006
- Product descriptionMK-0752
- Packaging10mg
- Price$230
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4006
- Product descriptionMK-0752
- Packaging50mg
- Price$590
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4006
- Product descriptionMK-0752
- Packaging100mg
- Price$1080
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60449
- Product descriptionMK-0752 ≥98%
- Packaging5mg
- Price$358
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16706
- Product descriptionMK-0752 ≥98%
- Packaging1mg
- Price$68
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16706
- Product descriptionMK-0752 ≥98%
- Packaging5mg
- Price$302
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16706
- Product descriptionMK-0752 ≥98%
- Packaging10mg
- Price$435
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM202948
- Product description3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoicacid 98%
- Packaging100mg
- Price$715
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0253
- Product descriptionMK-0752 98.00%
- Packaging5mg
- Price$238
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0253
- Product descriptionMK-0752 98.00%
- Packaging10mg
- Price$311
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7591 | 3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoicacid | 100mg | $2431 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004452 | MK-0752 95.00% | 1MG | $173.25 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004452 | MK-0752 95.00% | 5MG | $500.15 | 2021-12-16 | Buy |
| ApexBio Technology | A4006 | MK-0752 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A4006 | MK-0752 | 5mg | $170 | 2021-12-16 | Buy |
| ApexBio Technology | A4006 | MK-0752 | 10mM(in 1mL DMSO) | $220 | 2021-12-16 | Buy |
| ApexBio Technology | A4006 | MK-0752 | 10mg | $230 | 2021-12-16 | Buy |
| ApexBio Technology | A4006 | MK-0752 | 50mg | $590 | 2021-12-16 | Buy |
| ApexBio Technology | A4006 | MK-0752 | 100mg | $1080 | 2021-12-16 | Buy |
| Arctom | CFN60449 | MK-0752 ≥98% | 5mg | $358 | 2021-12-16 | Buy |
| Cayman Chemical | 16706 | MK-0752 ≥98% | 1mg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 16706 | MK-0752 ≥98% | 5mg | $302 | 2024-03-01 | Buy |
| Cayman Chemical | 16706 | MK-0752 ≥98% | 10mg | $435 | 2024-03-01 | Buy |
| Chemenu | CM202948 | 3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoicacid 98% | 100mg | $715 | 2021-12-16 | Buy |
| ChemScene | CS-0253 | MK-0752 98.00% | 5mg | $238 | 2021-12-16 | Buy |
| ChemScene | CS-0253 | MK-0752 98.00% | 10mg | $311 | 2021-12-16 | Buy |
Properties
Melting point :166.6-167.5 °C(Solv: isopropyl acetate (108-21-4); heptane (142-82-5))
Boiling point :616.9±55.0 °C(Predicted)
Density :1.361
storage temp. :Store at -20°C
solubility :≥22.15 mg/mL in DMSO; insoluble in H2O; ≥48.8 mg/mL in EtOH with ultrasonic
form :Powder
pka :4.76±0.10(Predicted)
Boiling point :616.9±55.0 °C(Predicted)
Density :1.361
storage temp. :Store at -20°C
solubility :≥22.15 mg/mL in DMSO; insoluble in H2O; ≥48.8 mg/mL in EtOH with ultrasonic
form :Powder
pka :4.76±0.10(Predicted)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain. MK-0752 is a potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in human neuroblastoma SH-SY5Y cells with an IC50 value of 5 nM. It is orally bioavailable and crosses the blood-brain barrier, as orally administered MK-0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys. Through its effects on the Notch pathway, MK-0752 reduces the number of breast cancer stem cells in tumorgrafts, enhancing the efficacy of the chemotherapy drug docetaxel in mice with breast cancer tumors.More related product prices
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Suppliers and manufacturers
career henan chemical co
![cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid](https://img.chemicalbook.com/ProductImageEN/2020-2/small/834df6b8-44e4-431c-9214-71b19e047577.jpg)
Hubei xin bonus chemical co. LTD
CONIER CHEM AND PHARMA LIMITED
TargetMol Chemicals Inc.
Zhejiang J&C Biological Technology Co.,Limited
CR Corporation Lomited
Alfa Chemistry
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
GIHI CHEMICALS CO.,LIMITED
$3.00 /1KG
cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid CAS:471905-41-6
cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid CAS:471905-41-6