DAPT
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- $6 - $3658
- Product name: DAPT
- CAS: 208255-80-5
- MF: C23H26F2N2O4
- MW: 432.46
- EINECS:
- MDL Number:MFCD04974585
- Synonyms:LY-374973, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester;N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethylester;SC-201315;(2S)-N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester;DAPT (enzyme inhibitor);GSI-IX;γ-Secretase Inhibitor IX;tert-butyl (2R)-[((2S)-2-{[(3,5-difluorophenyl)acetyl]aMino}propanoyl)aMino](phenyl)ethanoate
93 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Activate Scientific
- Adipogen Life Sciences
- AK Scientific
- Ambeed
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- TCI Chemical
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 1unit
- 1mg
- 5mg
- 10mg
- 20mg
- 25.00mg
- 25mg
- 2x25mg
- 50.00mg
- 50mg
- 100mg
- 200mg
- 100.00mg
- 10mM*1mLinDMSO(Solution)
- 250mg
- 10mM*1mLinDMSO
- EvaluationSample
- 1g
- 1 unit
- 5 mg
- 10 mg
- 500mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM(in 1mL DMSO)
- 5g
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA002JIP
- Product descriptiontert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98%
- Packaging1mg
- Price$6
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002JIP
- Product descriptiontert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98%
- Packaging5mg
- Price$17
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002JIP
- Product descriptiontert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98%
- Packaging10mg
- Price$28
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002JIP
- Product descriptiontert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98%
- Packaging25mg
- Price$49
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002JIP
- Product descriptiontert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98%
- Packaging100mg
- Price$109
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA002JIP
- Product descriptiontert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate ≥98%
- Packaging1g
- Price$1028
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10311
- Product descriptionDAPT 98%
- Packaging100MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10311
- Product descriptionDAPT 98%
- Packaging25MG
- Price$50
- Updated2026-05-27
- Buy
- ManufacturerActivate Scientific
- Product numberAS116025
- Product descriptionDAPT 98+%
- Packaging5mg
- Price$134
- Updated2021-12-16
- Buy
- ManufacturerActivate Scientific
- Product numberAS116025
- Product descriptionDAPT 98+%
- Packaging25mg
- Price$280
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0016-M025
- Product descriptionDAPT ≥98%(NMR)
- Packaging25mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0016-M005
- Product descriptionDAPT ≥98%(NMR)
- Packaging5mg
- Price$65
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product numberJ96086
- Product descriptionDAPT
- Packaging10mg
- Price$115
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7572
- Product descriptionDAPT
- Packaging25mg
- Price$458
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150458
- Product descriptionDAPT 98+%
- Packaging1g
- Price$408
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA150458
- Product descriptionDAPT 98+%
- Packaging50mg
- Price$86
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA002JIP | tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98% | 1mg | $6 | 2026-05-28 | Buy |
| aablocks | AA002JIP | tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98% | 5mg | $17 | 2026-05-28 | Buy |
| aablocks | AA002JIP | tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98% | 10mg | $28 | 2026-05-28 | Buy |
| aablocks | AA002JIP | tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98% | 25mg | $49 | 2026-05-28 | Buy |
| aablocks | AA002JIP | tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate 98% | 100mg | $109 | 2026-05-28 | Buy |
| aablocks | AA002JIP | tert-Butyl (S)-2-((S)-2-(2-(3,5-difluorophenyl)acetamido)propanamido)-2-phenylacetate ≥98% | 1g | $1028 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10311 | DAPT 98% | 100MG | $110 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10311 | DAPT 98% | 25MG | $50 | 2026-05-27 | Buy |
| Activate Scientific | AS116025 | DAPT 98+% | 5mg | $134 | 2021-12-16 | Buy |
| Activate Scientific | AS116025 | DAPT 98+% | 25mg | $280 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0016-M025 | DAPT ≥98%(NMR) | 25mg | $190 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0016-M005 | DAPT ≥98%(NMR) | 5mg | $65 | 2026-05-06 | Buy |
| AK Scientific | J96086 | DAPT | 10mg | $115 | 2021-12-16 | Buy |
| AK Scientific | X7572 | DAPT | 25mg | $458 | 2021-12-16 | Buy |
| Ambeed | A150458 | DAPT 98+% | 1g | $408 | 2021-12-16 | Buy |
| Ambeed | A150458 | DAPT 98+% | 50mg | $86 | 2021-12-16 | Buy |
Properties
Boiling point :612.2±55.0 °C(Predicted)
alpha :+40.0~+47.0°(D/20℃)(c=0.5,DMSO)
Density :1.213
storage temp. :2-8°C
solubility :DMSO: ~18 mg/mL
form :solid
pka :12.82±0.46(Predicted)
color :white
biological source :synthetic (organic)
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :DWJXYEABWRJFSP-XOBRGWDASA-N
SMILES :C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](C(=O)OC(C)(C)C)c2ccccc2
CAS DataBase Reference :208255-80-5
alpha :+40.0~+47.0°(D/20℃)(c=0.5,DMSO)
Density :1.213
storage temp. :2-8°C
solubility :DMSO: ~18 mg/mL
form :solid
pka :12.82±0.46(Predicted)
color :white
biological source :synthetic (organic)
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :DWJXYEABWRJFSP-XOBRGWDASA-N
SMILES :C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@@H](C(=O)OC(C)(C)C)c2ccccc2
CAS DataBase Reference :208255-80-5
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
γ-Secretase is a multi-subunit aspartyl protease that cleaves amyloid precursor protein (APP) and many other type 1 transmembrane proteins, including Notch, E-cadherin, and ErbB4. The proteolysis of APP by secretases produces beta amyloid (Aβ), a 39- to 42-amino acid peptide which forms the amyloid plaques that are characteristic of Alzheimer’s disease. DAPT is an inhibitor of γ-secretase, blocking the production of total Aβ in human primary neuronal cultures with an IC50 value of 115 nM and Aβ42 with an IC50 value of 200 nM. DAPT is also effective in vivo, reducing brain levels of Aβ when given orally to mice that are transgenic for human APPV717F or to rats. Through its effects on γ-secretase, DAPT indirectly inhibits Notch, affecting cell signaling and cell differentiation.Suppliers and manufacturers
Shanghai Boyle Chemical Co., Ltd.
J & K SCIENTIFIC LTD.
3B Pharmachem (Wuhan) International Co.,Ltd.
ZHIWE CHEMTECH CO LTD
Chembest Research Laboratories Limited
TCI (Shanghai) Development Co., Ltd.
Ark Pharm, Inc.
VDM Biochemicals
Shanghai Hanhong Scientific Co.,Ltd.
Jinan Trio PharmaTech Co., Ltd.