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ChemicalBook >> CAS DataBase List >> 5-Fluorouracil

5-Fluorouracil

5-Fluorouracil price.
  • $26 - $953
  • Product name: 5-Fluorouracil
  • CAS: 51-21-8
  • MF: C4H3FN2O2
  • MW: 130.08
  • EINECS:200-085-6
  • MDL Number:MFCD00006018
  • Synonyms:[180]-5-Fluorouracil;2,4(1H,3H)-Pyrimidinedione, 5-fluoro-;2,4-dioxo-5-fluoropyrimidine ;3h)-pyrimidinedione,5-fluoro-4(1h ;5-faracil ;5-Flouracyl;Fluoroplex;fluoro-uracile
21 prices
Selected condition:

Brand

  • Alfa Aesar
  • Cayman Chemical
  • Sigma-Aldrich
  • TCI Chemical

Package

  • f0250000
  • 50mg
  • 100mg
  • 8185050005
  • 250mg
  • 500mg
  • 1gm
  • 1g
  • 5g
  • 10g
  • 25g
  • 50g
  • 100g
  • ManufacturerAlfa Aesar
  • Product numberA13456
  • Product description5-Fluorouracil, 99%
  • Packaging5g
  • Price$71.2
  • Updated2018-11-13
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA13456
  • Product description5-Fluorouracil, 99%
  • Packaging25g
  • Price$277
  • Updated2018-11-13
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberA13456
  • Product description5-Fluorouracil, 99%
  • Packaging100g
  • Price$953
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number14416
  • Product description5-Fluorouracil ≥95%
  • Packaging5g
  • Price$26
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number14416
  • Product description5-Fluorouracil ≥95%
  • Packaging10g
  • Price$53
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number14416
  • Product description5-Fluorouracil ≥95%
  • Packaging25g
  • Price$126
  • Updated2018-11-13
  • Buy
  • ManufacturerCayman Chemical
  • Product number14416
  • Product description5-Fluorouracil ≥95%
  • Packaging50g
  • Price$224
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberF6627
  • Product description5-Fluorouracil ≥99% (HPLC), powder
  • Packaging10g
  • Price$228
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberF8423
  • Product descriptionFluorouracil meets USP testing specifications
  • Packaging5g
  • Price$171
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberF0250000
  • Product descriptionFluorouracil European Pharmacopoeia (EP) Reference Standard
  • Packagingf0250000
  • Price$179
  • Updated2018-11-23
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number04541
  • Product description5-Fluorouracil certified reference material, TraceCERT
  • Packaging50mg
  • Price$141
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number343922
  • Product description5-Fluorouracil Potent antitumor agent.
  • Packaging1gm
  • Price$53.6
  • Updated2018-11-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberF6627
  • Product description5-Fluorouracil ≥99% (HPLC), powder
  • Packaging1g
  • Price$35.8
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number03738
  • Product description5-Fluorouracil analytical standard
  • Packaging100mg
  • Price$50.7
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberPHR1227
  • Product descriptionFluorouracil Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500mg
  • Price$81.3
  • Updated2018-11-13
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  • ManufacturerSigma-Aldrich
  • Product number8.18505
  • Product description5-Fluorouracil for synthesis. CAS 51-21-8, pH 4.3 - 5.3 (10 g/l, H O, 20 °C)., for synthesis
  • Packaging8185050005
  • Price$91
  • Updated2018-11-23
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Alfa Aesar A13456 5-Fluorouracil, 99% 5g $71.2 2018-11-13 Buy
Alfa Aesar A13456 5-Fluorouracil, 99% 25g $277 2018-11-13 Buy
Alfa Aesar A13456 5-Fluorouracil, 99% 100g $953 2018-11-13 Buy
Cayman Chemical 14416 5-Fluorouracil ≥95% 5g $26 2018-11-13 Buy
Cayman Chemical 14416 5-Fluorouracil ≥95% 10g $53 2018-11-13 Buy
Cayman Chemical 14416 5-Fluorouracil ≥95% 25g $126 2018-11-13 Buy
Cayman Chemical 14416 5-Fluorouracil ≥95% 50g $224 2018-11-13 Buy
Sigma-Aldrich F6627 5-Fluorouracil ≥99% (HPLC), powder 10g $228 2018-11-13 Buy
Sigma-Aldrich F8423 Fluorouracil meets USP testing specifications 5g $171 2018-11-13 Buy
Sigma-Aldrich F0250000 Fluorouracil European Pharmacopoeia (EP) Reference Standard f0250000 $179 2018-11-23 Buy
Sigma-Aldrich 04541 5-Fluorouracil certified reference material, TraceCERT 50mg $141 2018-11-13 Buy
Sigma-Aldrich 343922 5-Fluorouracil Potent antitumor agent. 1gm $53.6 2018-11-20 Buy
Sigma-Aldrich F6627 5-Fluorouracil ≥99% (HPLC), powder 1g $35.8 2018-11-13 Buy
Sigma-Aldrich 03738 5-Fluorouracil analytical standard 100mg $50.7 2018-11-13 Buy
Sigma-Aldrich PHR1227 Fluorouracil Pharmaceutical Secondary Standard; Certified Reference Material 500mg $81.3 2018-11-13 Buy
Sigma-Aldrich 8.18505 5-Fluorouracil for synthesis. CAS 51-21-8, pH 4.3 - 5.3 (10 g/l, H O, 20 °C)., for synthesis 8185050005 $91 2018-11-23 Buy

Properties

Melting point: :282-286 °C (dec.)(lit.)
Boiling point: :190-200°C/0.1mmHg
Density  :1.4593 (estimate)
storage temp.  :Store at 0-5
solubility  :H2O: 10 mg/mL, clear
form  :powder
pka :pKa 8.0±0.1 (H2O) (Uncertain);3.0±0.1(H2O) (Uncertain)
color  :white
PH :4.3-5.3 (10g/l, H2O, 20℃)
Water Solubility  :12.2 g/L 20 ºC
Sensitive  :Air Sensitive
Merck  :14,4181
BRN  :127172
Stability: :Stable. Light sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases.
InChIKey :GHASVSINZRGABV-UHFFFAOYSA-N
CAS DataBase Reference :51-21-8(CAS DataBase Reference)
NIST Chemistry Reference :2,4-Pyrimidinedione, 5-fluoro-(51-21-8)
EPA Substance Registry System :2,4(1H,3H)-Pyrimidinedione, 5-fluoro-(51-21-8)

Safety Information

Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

5-Fluorouracil is a pyrimadine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. 5-Fluorouracil has been widely used to treat many gastrointestinal tract adenocarcinomas. However, its clinical application is greatly limited due to drug resistance.

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