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ChemicalBook >> CAS DataBase List >> Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-

Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-

Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)- price.
  • $110 - $2500
  • Product name: Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-
  • CAS: 540769-28-6
  • MF: C25H30N4O2
  • MW: 418.53
  • EINECS:
  • MDL Number:MFCD07772352
  • Synonyms:Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-;Palosuran;ACT 058362;ACT 058362; PALOSURAN,;1-[2-(4-Benzyl-4-hydroxypiperidin-1-yl)ethyl]-3-(2-methylquinolin-4-yl)urea;N-[2-[4-Hydroxy-4-(phenylmethyl)-1-piperidinyl]ethyl]-N'-(2-methyl-4-quinolinyl)urea;ACT058362;ACT-058362;ACT 058362; PALOSURAN,, >98%
15 prices
Selected condition:
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 10mM(in 1mL DMSO)
  • 50mg
  • 100mg
  • 1g
  • ManufacturerAK Scientific
  • Product number5897CR
  • Product descriptionPalosuran
  • Packaging10mg
  • Price$1061
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1304
  • Product descriptionPalosuran
  • Packaging5mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1304
  • Product descriptionPalosuran
  • Packaging10mM(in 1mL DMSO)
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1304
  • Product descriptionPalosuran
  • Packaging10mg
  • Price$361
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1304
  • Product descriptionPalosuran
  • Packaging25mg
  • Price$523
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1304
  • Product descriptionPalosuran
  • Packaging50mg
  • Price$855
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1304
  • Product descriptionPalosuran
  • Packaging100mg
  • Price$1330
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number23460
  • Product descriptionPalosuran
  • Packaging1mg
  • Price$110
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23460
  • Product descriptionPalosuran
  • Packaging5mg
  • Price$459
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number23460
  • Product descriptionPalosuran
  • Packaging10mg
  • Price$864
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1722
  • Product descriptionPalosuran 99.33%
  • Packaging5mg
  • Price$264
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1722
  • Product descriptionPalosuran 99.33%
  • Packaging10mg
  • Price$420
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1722
  • Product descriptionPalosuran 99.33%
  • Packaging50mg
  • Price$1080
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31001564
  • Product descriptionPalosuran 98+%
  • Packaging5mg
  • Price$351
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC7970
  • Product descriptionACT058362(Palosuran) >98%
  • Packaging1g
  • Price$2500
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 5897CR Palosuran 10mg $1061 2021-12-16 Buy
ApexBio Technology B1304 Palosuran 5mg $238 2021-12-16 Buy
ApexBio Technology B1304 Palosuran 10mM(in 1mL DMSO) $320 2021-12-16 Buy
ApexBio Technology B1304 Palosuran 10mg $361 2021-12-16 Buy
ApexBio Technology B1304 Palosuran 25mg $523 2021-12-16 Buy
ApexBio Technology B1304 Palosuran 50mg $855 2021-12-16 Buy
ApexBio Technology B1304 Palosuran 100mg $1330 2021-12-16 Buy
Cayman Chemical 23460 Palosuran 1mg $110 2024-03-01 Buy
Cayman Chemical 23460 Palosuran 5mg $459 2024-03-01 Buy
Cayman Chemical 23460 Palosuran 10mg $864 2024-03-01 Buy
ChemScene CS-1722 Palosuran 99.33% 5mg $264 2021-12-16 Buy
ChemScene CS-1722 Palosuran 99.33% 10mg $420 2021-12-16 Buy
ChemScene CS-1722 Palosuran 99.33% 50mg $1080 2021-12-16 Buy
Crysdot CD31001564 Palosuran 98+% 5mg $351 2021-12-16 Buy
DC Chemicals DC7970 ACT058362(Palosuran) >98% 1g $2500 2021-12-16 Buy

Properties

Boiling point :612.9±55.0 °C(Predicted)
Density :1.235±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 0.5 mg/ml
form :A crystalline solid
pka :12.95±0.43(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Palosuran is an antagonist of the urotensin II receptor (UTR; IC50s = 3.6 and 1,475 nM for CHO cell membranes expressing human and rat recombinant receptors, respectively). It inhibits contraction of isolated rat aortic rings induced by urotensin II (Item Nos. 24711 | 24753) in a concentration-dependent manner. Palosuran (300 mg/kg twice per day) reduces plasma endothelin-1 , urotensin II, and TGF-β1 levels, as well as the main pulmonary arterial pressure and right ventricular hypertrophy index in a rat model of pulmonary arterial hypertension (PAH) induced by monocrotaline . Palosuran (300 mg/kg per day) reduces serum glucose, cholesterol, and triglyceride levels and increases survival in a rat model of diabetes induced by streptozotocin (STZ; ). It also decreases albuminuria and global kidney lesion scores in STZ-induced diabetic rats.