7-HYDROXY METHOTREXATE
|
- $89 - $2194.5
- Product name: 7-HYDROXY METHOTREXATE
- CAS: 5939-37-7
- MF: C20H22N8O6
- MW: 470.44
- EINECS:
- MDL Number:MFCD00674903
- Synonyms:7-HYDROXY METHOTREXATE;7-HYDROXY METHOXTREXATE;7-OH-MTX;N-[4-[[(2,4-Diamino-7-hydroxypteridin-6-yl)methyl](methyl)amino]benzoyl]-L-glutamic acid;N-[4-[[(2,4-Diamino-7-hydroxypteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid;N-[4-[[(2,4-DiaMino-7,8-dihydro-7-oxo-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid;NSC 380962;Methotrexate 7-Hydroxy Metabolite
5 prices
Selected condition：
Brand
- American Custom Chemicals Corporation
- Cayman Chemical
- Medical Isotopes, Inc.
Package
- 500μg
- 1MG
- 10MG
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005869
- Product description7-HYDROXY METHOXTREXATE 95.00%
- Packaging1MG
- Price$700.35
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0005869
- Product description7-HYDROXY METHOXTREXATE 95.00%
- Packaging10MG
- Price$2194.5
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21788
- Product description7-hydroxy Methotrexate ≥96%
- Packaging500μg
- Price$89
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21788
- Product description7-hydroxy Methotrexate ≥96%
- Packaging1mg
- Price$169
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number10849
- Product description7-HydroxyMethotrexate 98%
- Packaging1mg
- Price$990
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | API0005869 | 7-HYDROXY METHOXTREXATE 95.00% | 1MG | $700.35 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0005869 | 7-HYDROXY METHOXTREXATE 95.00% | 10MG | $2194.5 | 2021-12-16 | Buy |
| Cayman Chemical | 21788 | 7-hydroxy Methotrexate ≥96% | 500μg | $89 | 2021-12-16 | Buy |
| Cayman Chemical | 21788 | 7-hydroxy Methotrexate ≥96% | 1mg | $169 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 10849 | 7-HydroxyMethotrexate 98% | 1mg | $990 | 2021-12-16 | Buy |
Properties
Melting point :230°C dec.
Boiling point :571.95°C (rough estimate)
Density :1.4416 (rough estimate)
refractive index :1.6910 (estimate)
storage temp. :−20°C
solubility :DMSO: slightly soluble,Ethanol: slightly soluble
form :A solid
pka :3.48±0.10(Predicted)
Stability :Hygroscopic
CAS DataBase Reference :5939-37-7
Boiling point :571.95°C (rough estimate)
Density :1.4416 (rough estimate)
refractive index :1.6910 (estimate)
storage temp. :−20°C
solubility :DMSO: slightly soluble,Ethanol: slightly soluble
form :A solid
pka :3.48±0.10(Predicted)
Stability :Hygroscopic
CAS DataBase Reference :5939-37-7
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
7-Hydroxy Methotrexate is the metabolite of methotrexate, a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR. Methotrexate has also been shown to modulate inflammation by promoting adenosine release or inhibiting transmethylation reactions. Methotrexate was also noted to decrease IL-1 production in adherent splenic cells.Related product price
- 5-Hydroxytryptophan
$25-1363.97 - DL-DOPA
$27.8-1208.75 - 19741-14-1
$50-2200