D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
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- $57 - $467
- Product name: D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
- CAS: 73257-80-4
- MF: C23H39ClN2O3
- MW: 427.02
- EINECS:
- MDL Number:MFCD00236490
- Synonyms:(+/-)-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HYDROCHLORIDE;(+/-)-THREO-PDMP HYDROCHLORIDE;(+/-)-PDMP HCL;(+/-)-PDMP HYDROCHLORIDE;N-[2-HYDROXY-1-(4-MORPHOLINYLMETHYL)-2-PHENYLETHYL]-DECANAMIDE, HYDROCHLORIDE;N-[2-HYDROXY-1-(4-MORPHOLINYLMETHYL)-2-PHENYLETHYL]-DECANAMIDE, MONOHYDROCHLORIDE;DL-PDMP;D,L-THREO-1-PHENYL-2-DECANOYLAMINO-3-MORPHOLINO-1-PROPANOL HCL
5 prices
Selected condition：
Brand
- Cayman Chemical
- TRC
Package
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerCayman Chemical
- Product number62595
- Product descriptionPDMP (hydrochloride) ≥98%
- Packaging10mg
- Price$57
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number62595
- Product descriptionPDMP (hydrochloride) ≥98%
- Packaging25mg
- Price$132
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number62595
- Product descriptionPDMP (hydrochloride) ≥98%
- Packaging50mg
- Price$249
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number62595
- Product descriptionPDMP (hydrochloride) ≥98%
- Packaging100mg
- Price$467
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberP181203
- Product descriptionDL-PDMP
- Packaging25mg
- Price$90
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 62595 | PDMP (hydrochloride) ≥98% | 10mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 62595 | PDMP (hydrochloride) ≥98% | 25mg | $132 | 2024-03-01 | Buy |
| Cayman Chemical | 62595 | PDMP (hydrochloride) ≥98% | 50mg | $249 | 2024-03-01 | Buy |
| Cayman Chemical | 62595 | PDMP (hydrochloride) ≥98% | 100mg | $467 | 2024-03-01 | Buy |
| TRC | P181203 | DL-PDMP | 25mg | $90 | 2021-12-16 | Buy |
Properties
storage temp. :−20°C
solubility :DMF: 25 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS(pH 7.2)(1:5): .05 mg/ml
form :A crystalline solid
solubility :DMF: 25 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS(pH 7.2)(1:5): .05 mg/ml
form :A crystalline solid
Safety Information
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Description
PDMP is a ceramide analog first prepared in a search for inhibitors of glucosylceramide synthase. PDMP has two adjacent chiral centers (C1 and C2) allowing for the formation of four possible isomers. PDMP contains all four of these stereoisomers. Treatment of cultured cells with PDMP reduces the synthesis of sphingosine and its derivatives, increases cellular ceramide, and induces cell cycle arrest. The ability to inhibit glucosylceramide synthase has been found to reside in the D-threo (1R,2R) enantiomer. Other activities, such as alkaline ceramidase inhibition and cytotoxicity, may involve interactions between PDMP isomers and/or direct activities of the other three isomeric PDMP compounds. By inhibiting β-1,4-galactosyltransferase 6, PDMP can also prevent the synthesis of lactosylceramide, a known promotor of neuroinflammation in mice during chronic experimental autoimmune encephalomyelitis, a model of multiple sclerosis.More related product prices