2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
|
- $36 - $860
- Product name: 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride
- CAS: 858474-14-3
- MF: C22H25ClN2O2
- MW: 384.9
- EINECS:
- MDL Number:MFCD22666390
- Synonyms:2-(P-METHOXYPHENYL)-Α-2-PIPERIDYL-4-QUINOLINEMETHANOL DIHYDROCHLORIDE;2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanol Dihydrochloride;[2-(4-Methoxyphenyl)4-quinolinyl]-(piperidin-2-y)-methanol dihydrochloride;NSC23925;NSC-23925;4-Quinolinemethanol, 2-(4-methoxyphenyl)-α-2-piperidinyl-, hydrochloride;(2-(4-Methoxyphenyl)quinolin-4-yl)(piperidin-2-yl)methanol dihydrochloride;NSC23925 HCl
12 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- ChemScene
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- ManufacturerAK Scientific
- Product numberSYN5211
- Product descriptionNSC-23925
- Packaging10mg
- Price$150
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number21947
- Product descriptionNSC 23925
- Packaging1mg
- Price$36
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21947
- Product descriptionNSC 23925
- Packaging5mg
- Price$105
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21947
- Product descriptionNSC 23925
- Packaging10mg
- Price$155
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number21947
- Product descriptionNSC 23925
- Packaging25mg
- Price$341
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0016032
- Product descriptionNSC23925 99.48%
- Packaging5mg
- Price$80
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0016032
- Product descriptionNSC23925 99.48%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0016032
- Product descriptionNSC23925 99.48%
- Packaging25mg
- Price$320
- Updated2021-12-16
- Buy
- ManufacturerMedical Isotopes, Inc.
- Product number59896
- Product description2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanolDiHCl
- Packaging50mg
- Price$860
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0372
- Product descriptionNSC23925 ≥98% (HPLC)
- Packaging5mg
- Price$115
- Updated2022-05-15
- Buy
- ManufacturerSigma-Aldrich
- Product numberSML0372
- Product descriptionNSC23925 ≥98% (HPLC)
- Packaging25mg
- Price$266
- Updated2025-07-31
- Buy
- ManufacturerTRC
- Product numberM266205
- Product description2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanolDihydrochloride
- Packaging25mg
- Price$255
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5211 | NSC-23925 | 10mg | $150 | 2021-12-16 | Buy |
| Cayman Chemical | 21947 | NSC 23925 | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 21947 | NSC 23925 | 5mg | $105 | 2024-03-01 | Buy |
| Cayman Chemical | 21947 | NSC 23925 | 10mg | $155 | 2024-03-01 | Buy |
| Cayman Chemical | 21947 | NSC 23925 | 25mg | $341 | 2024-03-01 | Buy |
| ChemScene | CS-0016032 | NSC23925 99.48% | 5mg | $80 | 2021-12-16 | Buy |
| ChemScene | CS-0016032 | NSC23925 99.48% | 10mg | $140 | 2021-12-16 | Buy |
| ChemScene | CS-0016032 | NSC23925 99.48% | 25mg | $320 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 59896 | 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanolDiHCl | 50mg | $860 | 2021-12-16 | Buy |
| Sigma-Aldrich | SML0372 | NSC23925 ≥98% (HPLC) | 5mg | $115 | 2022-05-15 | Buy |
| Sigma-Aldrich | SML0372 | NSC23925 ≥98% (HPLC) | 25mg | $266 | 2025-07-31 | Buy |
| TRC | M266205 | 2-(4-Methoxyphenyl)-α-2-piperidinyl-4-quinolinemethanolDihydrochloride | 25mg | $255 | 2021-12-16 | Buy |
Properties
storage temp. :room temp
solubility :H2O: soluble5mg/mL (clear solution)
form :powder
color :white to beige
Water Solubility :H2O: 5mg/mL (clear solution)
InChI :1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H
InChIKey :WGWOQHWZXLGPNG-UHFFFAOYSA-N
SMILES :Cl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2
solubility :H2O: soluble5mg/mL (clear solution)
form :powder
color :white to beige
Water Solubility :H2O: 5mg/mL (clear solution)
InChI :1S/C22H24N2O2.2ClH/c1-26-16-11-9-15(10-12-16)21-14-18(17-6-2-3-7-19(17)24-21)22(25)20-8-4-5-13-23-20;;/h2-3,6-7,9-12,14,20,22-23,25H,4-5,8,13H2,1H3;2*1H
InChIKey :WGWOQHWZXLGPNG-UHFFFAOYSA-N
SMILES :Cl.Cl.COc1ccc(cc1)-c2cc(C(O)C3CCCCN3)c4ccccc4n2
Safety Information
| Symbol(GHS): |
|
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Danger | ||||||||||||||
| Hazard statements: |
|
||||||||||||||
| Precautionary statements: |
|
Description
NSC 23925 is a non-substrate inhibitor of P-glycoprotein (P-gp). It selectively reverses multidrug resistance mediated by P-gp over resistance mediated by multidrug resistance-associated protein 1 (MRP1/ABCC1) or breast cancer resistance protein (BCRP/ABCG2). It resensitizes paclitaxel-resistant SKOV3TR and OVCAR-8TR cells to paclitaxel . NSC 23925 reverses P-gp efflux, increasing the intracellular accumulation of P-gp substrates, including calcein AM in multidrug-resistant SKOV3TR and OVCAR-8TR cells. It prevents paclitaxel-induced overexpression of the P-gp gene MDR1 and P-gp protein level increases in OVCAR-8 cells. It also prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model when administered at a dose of 50 mg/kg per day in combination with paclitaxel.Related product price
- Propylamine
$10-1212.75 - 4-PIPERIDINOL, PROPIONATE, HYDROCHLORIDE
$237-1468.5 - Propylene oxide
$10-677