2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE
![2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE price.](/CAS/GIF/905973-89-9.gif)
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- $35 - $5058.9
- Product name: 2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE
- CAS: 905973-89-9
- MF: C23H18Cl3FN4O3S
- MW: 555.84
- EINECS:
- MDL Number:MFCD09038682
- Synonyms:2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE;CGK733;A-PHENYL-N-[2,2,2-TRICHLORO-1-[[[(4-FLUORO-3-NITROPHENYL)AMINO]THIOXOMETHYL]AMINO]ETHYL]BENZENEACETAMIDE;α-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]benzeneacetamide;alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide;Benzeneacetamide, α-phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-;alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide CGK 733;CGK 733 alpha-Phenyl-N-[2,2,2-trichloro-1-[[[(4-fluoro-3-nitrophenyl)amino]thioxomethyl]amino]ethyl]-benzeneacetamide
31 prices
Selected condition：
Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biorbyt Ltd
- Cayman Chemical
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 25mg
- 10
- 5mg
- 100mg
- 1mg
- 10mg
- 50mg
- 50
- 250mg
- 500mg
- 1g
- 1000mg
- 50G
- 500G
- 10mM(in 1mL DMSO)
- ManufacturerAK Scientific
- Product numberX5280
- Product descriptionCGK733
- Packaging5mg
- Price$49
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA140835
- Product descriptionCGK733 98+%
- Packaging5mg
- Price$83
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA140835
- Product descriptionCGK733 98+%
- Packaging10mg
- Price$140
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA140835
- Product descriptionCGK733 98+%
- Packaging50mg
- Price$356
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0000356
- Product descriptionCGK733 95.00%
- Packaging10MG
- Price$685.21
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0000356
- Product descriptionCGK733 95.00%
- Packaging50MG
- Price$1138.78
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0000356
- Product descriptionCGK733 95.00%
- Packaging50G
- Price$2437.05
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCBL0000356
- Product descriptionCGK733 95.00%
- Packaging500G
- Price$5058.9
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8624
- Product descriptionCGK733
- Packaging10mg
- Price$70
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8624
- Product descriptionCGK733
- Packaging10mM(in 1mL DMSO)
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8624
- Product descriptionCGK733
- Packaging50mg
- Price$308
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180958
- Product descriptionCGK733 >98%
- Packaging100mg
- Price$615.4
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180958
- Product descriptionCGK733 >98%
- Packaging250mg
- Price$1208.7
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb180958
- Product descriptionCGK733 >98%
- Packaging1000mg
- Price$2395.3
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16242
- Product descriptionCGK733 ≥98%
- Packaging1mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16242
- Product descriptionCGK733 ≥98%
- Packaging5mg
- Price$57
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X5280 | CGK733 | 5mg | $49 | 2021-12-16 | Buy |
| Ambeed | A140835 | CGK733 98+% | 5mg | $83 | 2021-12-16 | Buy |
| Ambeed | A140835 | CGK733 98+% | 10mg | $140 | 2021-12-16 | Buy |
| Ambeed | A140835 | CGK733 98+% | 50mg | $356 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0000356 | CGK733 95.00% | 10MG | $685.21 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0000356 | CGK733 95.00% | 50MG | $1138.78 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0000356 | CGK733 95.00% | 50G | $2437.05 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CBL0000356 | CGK733 95.00% | 500G | $5058.9 | 2021-12-16 | Buy |
| ApexBio Technology | A8624 | CGK733 | 10mg | $70 | 2021-12-16 | Buy |
| ApexBio Technology | A8624 | CGK733 | 10mM(in 1mL DMSO) | $88 | 2021-12-16 | Buy |
| ApexBio Technology | A8624 | CGK733 | 50mg | $308 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180958 | CGK733 >98% | 100mg | $615.4 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180958 | CGK733 >98% | 250mg | $1208.7 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb180958 | CGK733 >98% | 1000mg | $2395.3 | 2021-12-16 | Buy |
| Cayman Chemical | 16242 | CGK733 ≥98% | 1mg | $35 | 2021-12-16 | Buy |
| Cayman Chemical | 16242 | CGK733 ≥98% | 5mg | $57 | 2024-03-01 | Buy |
Properties
Density :1.502±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :≥27.8 mg/mL in DMSO; insoluble in H2O; ≥5.55 mg/mL in EtOH with gentle warming and ultrasonic
pka :10.15±0.70(Predicted)
form :Pale yellow solid
storage temp. :Sealed in dry,2-8°C
solubility :≥27.8 mg/mL in DMSO; insoluble in H2O; ≥5.55 mg/mL in EtOH with gentle warming and ultrasonic
pka :10.15±0.70(Predicted)
form :Pale yellow solid
Safety Information
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Description
Ataxia-telangiectasia mutated (ATM) and ATM- and Rad3-related (ATR) kinases mediate the DNA damage response pathway in cells upon encounter with genotoxic agents. Their signaling can activate cell cycle arrest, DNA repair, induction of premature senescence, and cell death. Inhibiting this pathway is one strategy implemented to increase the therapeutic capacity of certain genotoxic anti-cancer regimens by sensitizing cancer cells to these agents. CGK733, a thiourea-containing compound, was originally identified as a specific inhibitor of ATR and ATM kinases (IC50 = ~ 200 nM). In prematurely senescent breast, lung, and colon cancer cells CGK733 reportedly suppresses ATM-mediated p21 expression required for survival, resulting in cell death. Human cancer cell lines exposed to both caffeine and CGK733 demonstrate a rapid decline in cyclin D1 protein levels and a reduction in retinoblastoma protein levels, which leads to the inhibition of their proliferation.More related product prices
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Suppliers and manufacturers
career henan chemical co
![2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE](https://img.chemicalbook.com/ProductImageEN/2018-12/small/fe498182-1055-4d7c-bbd5-8bbb37f80631.png)
ATK CHEMICAL COMPANY LIMITED
Hubei xin bonus chemical co. LTD
Chongqing Chemdad Co., Ltd
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
TargetMol Chemicals Inc.
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
$2.00 /1kg
2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE CAS:905973-89-9
2,2-DIPHENYL-N-(2,2,2-TRICHLORO-1-[3-(4-FLUORO-3-NITROPHENYL)THIOUREIDO]ETHYL)ACETAMIDE CAS:905973-89-9