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ChemicalBook >> CAS DataBase List >> ACK1-B19

ACK1-B19

$36 - $2365
Product name: ACK1-B19
CAS: 1234480-46-6
MF: C24H27N7O2
MW: 445.52
EINECS:
MDL Number:MFCD30742941
Synonyms:ACK1-B19;XMD8-87;CS-2588;XMD-8-87;XMD8 87;XMD 8 87;2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)-11-methyl-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one;5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-;XMD8-87 (ACK1-B19)

Price40 Properties Safety Information Description

40 prices

Selected condition：

Brand

aablocks
ACHEMBLOCK
AK Scientific
Ambeed
Arctom
Axon Medchem
Biosynth
Cayman Chemical
ChemScene
DC Chemicals
Tocris
TRC

Package

2x5mg
250mg
0.5g
10mM*1mLinDMSO(Solid+Solvent)
10
50
5 mg
10mM*1mLinDMSO(Solution)
1mg
5mg
10mg
25mg
50mg
100MG
1G

Manufactureraablocks
Product numberAA000KI6
Product description5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 97%
Packaging10mg
Price$77
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000KI6
Product description5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one ≥98%
Packaging1mg
Price$36
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000KI6
Product description5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 97%
Packaging5mg
Price$48
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000KI6
Product description5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 97%
Packaging25mg
Price$99
Updated2026-05-25
Buy

Manufactureraablocks
Product numberAA000KI6
Product description5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 97%
Packaging50mg
Price$169
Updated2026-05-25
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ManufacturerACHEMBLOCK
Product numberS86691
Product descriptionXMD8-87 98%
Packaging25MG
Price$175
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberS86691
Product descriptionXMD8-87 98%
Packaging5MG
Price$65
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberS86691
Product descriptionXMD8-87 98%
Packaging100MG
Price$435
Updated2026-05-27
Buy

ManufacturerACHEMBLOCK
Product numberS86691
Product descriptionXMD8-87 98%
Packaging1G
Price$1360
Updated2026-05-27
Buy

ManufacturerAK Scientific
Product number6234DK
Product description2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-11-methyl-5H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
Packaging1mg
Price$187
Updated2021-12-16
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ManufacturerAmbeed
Product numberA560552
Product descriptionXMD8-87 97%
Packaging5mg
Price$181
Updated2021-12-16
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ManufacturerAmbeed
Product numberA560552
Product descriptionXMD8-87 97%
Packaging25mg
Price$424
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA560552
Product descriptionXMD8-87 97%
Packaging10mg
Price$250
Updated2021-12-16
Buy

ManufacturerArctom
Product numberHY-15811
Product descriptionXMD8-87 99.57%
Packaging25mg
Price$328
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-15811
Product descriptionXMD8-87 99.57%
Packaging50mg
Price$499
Updated2026-05-26
Buy

ManufacturerArctom
Product numberHY-15811
Product descriptionXMD8-87 99.57%
Packaging100mg
Price$713
Updated2026-05-26
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA000KI6	5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 97%	10mg	$77	2026-05-25	Buy
aablocks	AA000KI6	5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one ≥98%	1mg	$36	2026-05-25	Buy
aablocks	AA000KI6	5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 97%	5mg	$48	2026-05-25	Buy
aablocks	AA000KI6	5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 97%	25mg	$99	2026-05-25	Buy
aablocks	AA000KI6	5,11-Dihydro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-11-methyl-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one 97%	50mg	$169	2026-05-25	Buy
ACHEMBLOCK	S86691	XMD8-87 98%	25MG	$175	2026-05-27	Buy
ACHEMBLOCK	S86691	XMD8-87 98%	5MG	$65	2026-05-27	Buy
ACHEMBLOCK	S86691	XMD8-87 98%	100MG	$435	2026-05-27	Buy
ACHEMBLOCK	S86691	XMD8-87 98%	1G	$1360	2026-05-27	Buy
AK Scientific	6234DK	2-[2-Methoxy-4-(4-methylpiperazin-1-yl)anilino]-11-methyl-5H-pyrimido[4,5-b][1,4]benzodiazepin-6-one	1mg	$187	2021-12-16	Buy
Ambeed	A560552	XMD8-87 97%	5mg	$181	2021-12-16	Buy
Ambeed	A560552	XMD8-87 97%	25mg	$424	2021-12-16	Buy
Ambeed	A560552	XMD8-87 97%	10mg	$250	2021-12-16	Buy
Arctom	HY-15811	XMD8-87 99.57%	25mg	$328	2026-05-26	Buy
Arctom	HY-15811	XMD8-87 99.57%	50mg	$499	2026-05-26	Buy
Arctom	HY-15811	XMD8-87 99.57%	100mg	$713	2026-05-26	Buy

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Properties

Density :1.283±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml
form :A crystalline solid
pka :10.18±0.20(Predicted)
color :White to yellow
InChIKey :LGLHCXISMKHLIK-UHFFFAOYSA-N
SMILES :N1(CCN(CC1)c2cc(c(cc2)Nc3nc4[n](c5c([c]([nH]c4cn3)=O)cccc5)C)OC)C

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC₅₀ value of 1.9 μM in HEK293T cells expressing human TNK2. It is selective for TNK2 over a panel of approximately 100 kinases with >90 and <50% inhibition for TNK2 and all other kinases tested, respectively. XMD8-87 inhibits growth of Ba/F3 cells expressing constitutively active mutant TNK2s (IC₅₀s = 0.1-77 nM) commonly found in leukemias but has no effect on cells expressing wild-type TNK2 (IC₅₀ = >1 μM).

More related product prices

6H-PyriMido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[2-Methoxy-4-(4-Methyl-1-piperazinyl)phenyl]aMino]-5,11-diMethyl- XMD16-5 1234480-50-2 XMD17 109

Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. Dalian Meilun Biotech Co., Ltd. MedChemexpress LLC Bide Pharmatech Ltd. Shanghai Lollane Biological Technology Co.,Ltd. SPIRO PHARMA Shanghai EFE Biological Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd. Shanghai Rechem science Co., Ltd.

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ACK1-B19

Properties

Safety Information

Description

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