AM 251
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- $28 - $1300
- Product name: AM 251
- CAS: 183232-66-8
- MF: C22H21Cl2IN4O
- MW: 555.24
- EINECS:
- MDL Number:MFCD01861181
- Synonyms:AM 251;1-(2,4-DICHLOROPHENYL)-5-(4-IODOPHENYL)-4-METHYL-N-1-PIPERIDINYL-1 H-PYRAZOLE-3-CARBOXAMIDE;N-(PIPERIDIN-1-YL)-5-(4-IODOPHENYL)-1-(2,4-DICHLOROPHENYL)-4-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE;AM-251 ,99%;AM 251 (pharmaceutical);1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-;1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide AM251;AM251;AM-251
61 prices
Selected condition：
Brand
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chem-Impex
- ChemScene
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- TCI Chemical
- Tocris
- TRC
- Usbiological
Package
- 2mg
- 250mg
- 1g
- 1mlx10mM(inDMSO)
- 1
- 1mg
- 50
- 10
- 10mM*1mLinDMSO(Solution)
- 1unit
- EvaluationSample
- 10mM*1mLinDMSO(Solid+Solvent)
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- ManufacturerApexBio Technology
- Product numberB1427
- Product descriptionAM 251
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1427
- Product descriptionAM251
- PackagingEvaluationSample
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1427
- Product descriptionAM 251
- Packaging5mg
- Price$40
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1427
- Product descriptionAM251
- Packaging5mg
- Price$51
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1427
- Product descriptionAM 251
- Packaging10mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1427
- Product descriptionAM251
- Packaging10mg
- Price$84
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1427
- Product descriptionAM 251
- Packaging50mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1427
- Product descriptionAM251
- Packaging50mg
- Price$324
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-15443
- Product descriptionAM251 99.09%
- Packaging50mg
- Price$300
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15443
- Product descriptionAM251 99.09%
- Packaging100mg
- Price$496
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15443
- Product descriptionAM251 99.09%
- Packaging25mg
- Price$179
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15443
- Product descriptionAM251 99.09%
- Packaging10mg
- Price$90
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15443
- Product descriptionAM251 99.09%
- Packaging5mg
- Price$53
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15443
- Product descriptionAM251 99.09%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$61
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-15443
- Product descriptionAM251 99.09%
- Packaging10mM*1mLinDMSO(Solution)
- Price$64
- Updated2026-05-26
- Buy
- ManufacturerAvaChem
- Product number6083
- Product descriptionAM251 98%
- Packaging10mg
- Price$72
- Updated2026-05-22
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ApexBio Technology | B1427 | AM 251 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | B1427 | AM251 | EvaluationSample | $30 | 2026-05-06 | Buy |
| ApexBio Technology | B1427 | AM 251 | 5mg | $40 | 2021-12-16 | Buy |
| ApexBio Technology | B1427 | AM251 | 5mg | $51 | 2026-05-06 | Buy |
| ApexBio Technology | B1427 | AM 251 | 10mg | $65 | 2021-12-16 | Buy |
| ApexBio Technology | B1427 | AM251 | 10mg | $84 | 2026-05-06 | Buy |
| ApexBio Technology | B1427 | AM 251 | 50mg | $250 | 2021-12-16 | Buy |
| ApexBio Technology | B1427 | AM251 | 50mg | $324 | 2026-05-06 | Buy |
| Arctom | HY-15443 | AM251 99.09% | 50mg | $300 | 2026-05-26 | Buy |
| Arctom | HY-15443 | AM251 99.09% | 100mg | $496 | 2026-05-26 | Buy |
| Arctom | HY-15443 | AM251 99.09% | 25mg | $179 | 2026-05-26 | Buy |
| Arctom | HY-15443 | AM251 99.09% | 10mg | $90 | 2026-05-26 | Buy |
| Arctom | HY-15443 | AM251 99.09% | 5mg | $53 | 2026-05-26 | Buy |
| Arctom | HY-15443 | AM251 99.09% | 10mM*1mLinDMSO(Solid+Solvent) | $61 | 2026-05-26 | Buy |
| Arctom | HY-15443 | AM251 99.09% | 10mM*1mLinDMSO(Solution) | $64 | 2026-05-26 | Buy |
| AvaChem | 6083 | AM251 98% | 10mg | $72 | 2026-05-22 | Buy |
Properties
Melting point :195-196℃
Density :1.65±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :DMSO: >10 mg/mL, soluble
pka :11.31±0.20(Predicted)
form :solid
color :white
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
InChIKey :BUZAJRPLUGXRAB-UHFFFAOYSA-N
SMILES :Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCCCC4
CAS DataBase Reference :183232-66-8
Density :1.65±0.1 g/cm3(Predicted)
storage temp. :Store at RT
solubility :DMSO: >10 mg/mL, soluble
pka :11.31±0.20(Predicted)
form :solid
color :white
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI :1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
InChIKey :BUZAJRPLUGXRAB-UHFFFAOYSA-N
SMILES :Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCCCC4
CAS DataBase Reference :183232-66-8
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
SR 141716A is a biarylpyrazole compound which has been considered for many years as the prototypical cannabinoid (CB) receptor antagonist. Some very close structural relatives of SR 141716A were recently prepared and tested for their ability to act as antagonists of the CB1 receptor. AM251 is one of these analogs, wherein the p-chloro group attached to the phenyl substituent at C-5 of the pyrazole ring is replaced with a p-iodo group. The resulting compound exhibits slightly better binding affinity for the CB1 receptor with a Ki value of 7.5 nM compound to SR 141716A, which has a Ki value of 11.5 nM. However AM251 is about two-fold more selective for the CB1 receptor when compared to SR 141716A.More related product prices
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