AMG 900
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- $35 - $3791
- Product name: AMG 900
- CAS: 945595-80-2
- MF: C28H21N7OS
- MW: 503.58
- EINECS:-0
- MDL Number:MFCD18633194
- Synonyms:N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine AMG 900;AMG 900;N-[4-[[3-(2-Amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-1-phthalazinamine;N-(4-((3-(2-Aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1;AMG-900;AMG900;1-Phthalazinamine, N-[4-[[3-(2-amino-4-pyrimidinyl)-2-pyridinyl]oxy]phenyl]-4-(4-methyl-2-thienyl)-;AMG 900 USP/EP/BP;AMG 900, 10 mM in DMSO
66 prices
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Brand
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
Package
- 10mM*1mLinDMSO(Solution)
- 1mg
- 2mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 5mg
- 10mM(1mLinDMSO)
- 10mg
- 2x5mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 200mg
- 1g
- 10mM(in 1mL DMSO)
- 10mM(in1mLDMSO)
- ManufacturerAK Scientific
- Product numberX7461
- Product descriptionN-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine
- Packaging25mg
- Price$158
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA563424
- Product descriptionAMG-900 98%
- Packaging50mg
- Price$137
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA563424
- Product descriptionAMG-900 98%
- Packaging5mg
- Price$35
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA563424
- Product descriptionAMG-900 98%
- Packaging10mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA563424
- Product descriptionAMG-900 98%
- Packaging25mg
- Price$98
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA563424
- Product descriptionAMG-900 98%
- Packaging100mg
- Price$217
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA563424
- Product descriptionAMG-900 98%
- Packaging250mg
- Price$395
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000701
- Product descriptionAMG-900 95.00%
- Packaging5MG
- Price$303.6
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4119
- Product descriptionAMG-900
- Packaging10mg
- Price$190
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4119
- Product descriptionAMG-900
- Packaging10mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4119
- Product descriptionAMG-900
- Packaging5mg
- Price$110
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4119
- Product descriptionAMG-900
- Packaging5mg
- Price$110
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4119
- Product descriptionAMG-900
- Packaging10mM(in 1mL DMSO)
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4119
- Product descriptionAMG-900
- Packaging10mM(in1mLDMSO)
- Price$120
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4119
- Product descriptionAMG-900
- Packaging50mg
- Price$590
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4119
- Product descriptionAMG-900
- Packaging50mg
- Price$590
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7461 | N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine | 25mg | $158 | 2021-12-16 | Buy |
| Ambeed | A563424 | AMG-900 98% | 50mg | $137 | 2021-12-16 | Buy |
| Ambeed | A563424 | AMG-900 98% | 5mg | $35 | 2021-12-16 | Buy |
| Ambeed | A563424 | AMG-900 98% | 10mg | $55 | 2021-12-16 | Buy |
| Ambeed | A563424 | AMG-900 98% | 25mg | $98 | 2021-12-16 | Buy |
| Ambeed | A563424 | AMG-900 98% | 100mg | $217 | 2021-12-16 | Buy |
| Ambeed | A563424 | AMG-900 98% | 250mg | $395 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000701 | AMG-900 95.00% | 5MG | $303.6 | 2021-12-16 | Buy |
| ApexBio Technology | A4119 | AMG-900 | 10mg | $190 | 2021-12-16 | Buy |
| ApexBio Technology | A4119 | AMG-900 | 10mg | $190 | 2026-05-06 | Buy |
| ApexBio Technology | A4119 | AMG-900 | 5mg | $110 | 2021-12-16 | Buy |
| ApexBio Technology | A4119 | AMG-900 | 5mg | $110 | 2026-05-06 | Buy |
| ApexBio Technology | A4119 | AMG-900 | 10mM(in 1mL DMSO) | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A4119 | AMG-900 | 10mM(in1mLDMSO) | $120 | 2026-05-06 | Buy |
| ApexBio Technology | A4119 | AMG-900 | 50mg | $590 | 2021-12-16 | Buy |
| ApexBio Technology | A4119 | AMG-900 | 50mg | $590 | 2026-05-06 | Buy |
Properties
Boiling point :778.7±70.0 °C(Predicted)
Density :1.380
storage temp. :2-8°C(protect from light)
solubility :≥25.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :4.79±0.30(Predicted)
color :Light yellow to yellow
InChIKey :IVUGFMLRJOCGAS-UHFFFAOYSA-N
SMILES :C1(NC2=CC=C(OC3=NC=CC=C3C3C=CN=C(N)N=3)C=C2)C2=C(C=CC=C2)C(C2SC=C(C)C=2)=NN=1
Density :1.380
storage temp. :2-8°C(protect from light)
solubility :≥25.2 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form :solid
pka :4.79±0.30(Predicted)
color :Light yellow to yellow
InChIKey :IVUGFMLRJOCGAS-UHFFFAOYSA-N
SMILES :C1(NC2=CC=C(OC3=NC=CC=C3C3C=CN=C(N)N=3)C=C2)C2=C(C=CC=C2)C(C2SC=C(C)C=2)=NN=1
Safety Information
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Description
Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Their expression is elevated in a variety of human cancers. AMG 900 is an orally bioavailable, selective Aurora kinase inhibitor with IC50 values of 5, 4, and 1 nM for Aurora A, B, and C, respectively. It is greater than 10-fold selective for Aurora kinases over p38α, TYK2, JNK2, Met, and Tie2 (IC50s = 53, 220, 520, 550, and 650 nM, respectively). At 2-3 nM, AMG 900 has been shown to inhibit the proliferation of 26 different tumor cell lines in vitro, including cell lines resistant to either the antimitotic agent paclitaxel or to other Aurora kinase inhibitors. Furthermore, AMG 900 is reported to be broadly active in multiple xenograft models, including three multidrug-resistant xenograft models, representing five tumor types.Related product price
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