AS703026
|
- $9 - $2996
- Product name: AS703026
- CAS: 1236699-92-5
- MF: C15H15FIN3O3
- MW: 431.2
- EINECS:
- MDL Number:MFCD16660676
- Synonyms:AS703026;N-[(2S)-2,3-Dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]-4-pyridinecarboxamide;(S)-N-(2,3-dihydroxypropyl)-3-(2-fluoro-4-iodophenylaMino)isonicotinaMide;4-PyridinecarboxaMide, N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)aMino]-;MSC1936369B;PiMasertib (AS-703026);AS703026/MSC1936369B;PiMasertib
71 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Apolloscientific
- Arctom
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- TRC
- Usbiological
Package
- 10mM*1mLinDMSO
- 200mg
- 100.00mg
- 10mM(in1mLDMSO)
- 250.00mg
- 500mg
- 1.00g
- 5g
- 10g
- 1mg
- 5mg
- 10mg
- 50mg
- 100mg
- 25MG
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- Manufactureraablocks
- Product numberAA000KUK
- Product descriptionAS-703026 98%
- Packaging1mg
- Price$9
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KUK
- Product descriptionAS-703026 98%
- Packaging5mg
- Price$12
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KUK
- Product descriptionAS-703026 98%
- Packaging10mg
- Price$16
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KUK
- Product descriptionAS-703026 98%
- Packaging50mg
- Price$36
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KUK
- Product descriptionAS-703026 98%
- Packaging100mg
- Price$55
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KUK
- Product descriptionAS-703026 98%
- Packaging250mg
- Price$92
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KUK
- Product descriptionAS-703026 98%
- Packaging1g
- Price$248
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15644
- Product descriptionPimasertib 98%
- Packaging100MG
- Price$280
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15644
- Product descriptionPimasertib 98%
- Packaging100MG
- Price$280
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15644
- Product descriptionPimasertib 98%
- Packaging1G
- Price$1050
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15644
- Product descriptionPimasertib 98%
- Packaging1G
- Price$1050
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15644
- Product descriptionPimasertib 98%
- Packaging25MG
- Price$95
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15644
- Product descriptionPimasertib 98%
- Packaging25MG
- Price$95
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15644
- Product descriptionPimasertib 98%
- Packaging5MG
- Price$35
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15644
- Product descriptionPimasertib 98%
- Packaging5MG
- Price$35
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberSYN-1190-M001
- Product descriptionAS-703026 ≥95%
- Packaging1mg
- Price$65
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000KUK | AS-703026 98% | 1mg | $9 | 2026-05-25 | Buy |
| aablocks | AA000KUK | AS-703026 98% | 5mg | $12 | 2026-05-25 | Buy |
| aablocks | AA000KUK | AS-703026 98% | 10mg | $16 | 2026-05-25 | Buy |
| aablocks | AA000KUK | AS-703026 98% | 50mg | $36 | 2026-05-25 | Buy |
| aablocks | AA000KUK | AS-703026 98% | 100mg | $55 | 2026-05-25 | Buy |
| aablocks | AA000KUK | AS-703026 98% | 250mg | $92 | 2026-05-25 | Buy |
| aablocks | AA000KUK | AS-703026 98% | 1g | $248 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15644 | Pimasertib 98% | 100MG | $280 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15644 | Pimasertib 98% | 100MG | $280 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15644 | Pimasertib 98% | 1G | $1050 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15644 | Pimasertib 98% | 1G | $1050 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15644 | Pimasertib 98% | 25MG | $95 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15644 | Pimasertib 98% | 25MG | $95 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15644 | Pimasertib 98% | 5MG | $35 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15644 | Pimasertib 98% | 5MG | $35 | 2026-05-27 | Buy |
| Adipogen Life Sciences | SYN-1190-M001 | AS-703026 ≥95% | 1mg | $65 | 2026-05-06 | Buy |
Properties
Boiling point :623.2±55.0 °C(Predicted)
Density :1.769
storage temp. :Store at -20°C
solubility :≥21.55 mg/mL in DMSO; insoluble in H2O; ≥10.36 mg/mL in EtOH with ultrasonic
form :solid
pka :12.82±0.46(Predicted)
color :Light yellow to khaki
InChI :InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1
InChIKey :VIUAUNHCRHHYNE-JTQLQIEISA-N
SMILES :C1=NC=CC(C(NC[C@H](O)CO)=O)=C1NC1=CC=C(I)C=C1F
Density :1.769
storage temp. :Store at -20°C
solubility :≥21.55 mg/mL in DMSO; insoluble in H2O; ≥10.36 mg/mL in EtOH with ultrasonic
form :solid
pka :12.82±0.46(Predicted)
color :Light yellow to khaki
InChI :InChI=1S/C15H15FIN3O3/c16-12-5-9(17)1-2-13(12)20-14-7-18-4-3-11(14)15(23)19-6-10(22)8-21/h1-5,7,10,20-22H,6,8H2,(H,19,23)/t10-/m0/s1
InChIKey :VIUAUNHCRHHYNE-JTQLQIEISA-N
SMILES :C1=NC=CC(C(NC[C@H](O)CO)=O)=C1NC1=CC=C(I)C=C1F
Safety Information
| Symbol(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | ||||||||||||||||||||||||||||
| Hazard statements: |
|
||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
The mitogen-activated protein kinases, MEK1 and 2, are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the Ras-Raf-MEK-ERK pathway and are often upregulated in a variety of cancer cell types. AS-703026 is an orally bioavailable small molecule that selectively binds to and inhibits MEK1/2, preventing the activation of downstream effector proteins and transcription factors. It potently inhibits growth and survival of human INA-6 multiple myeloma cells and cytokine-induced osteoclast differentiation with IC50 values of 10 and 18.2 nM, respectively. In mice bearing H929 MM xenograft tumors, 30 mg/kg AS-703026 reduced tumor growth significantly, which correlated with downregulated ERK1/2 activity, induced PARP cleavage, and decreased microvessels in vivo. At 10 μM, AS-703026 supressed proliferation and transformation of K-Ras mutated colorectal cancer cells resistant to EGFR antibody therapy.Related product price
- Erlotinib hydrochloride
$5-3498.6 - MG-132
$11-3568 - Selumetinib
$25-3538
