AT-56
|
- $15 - $2395.3
- Product name: AT-56
- CAS: 162640-98-4
- MF: C25H27N5
- MW: 397.52
- EINECS:200-256-5
- MDL Number:MFCD18086874
- Synonyms:AT56/AT-56;4-(DIBENZO[1,2-A:1',2'-E][7]ANNULEN-11-YLIDENE)-1-[4-(2H-TETRAZOL-5-YL)BUTYL]PIPERIDINE;4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(1H-tetrazol-5-yl)butyl]piperidine;4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-[4-(2H-tetrazol-5-yl)butyl]-piperidine;AT 56;4-Dibenzo[a,d]cyclohepten-5-ylidene-1-[4-(2H-tetrazol-5-yl)-butyl]-piperidine;AT 56, >=98%;CS-1414
48 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 5mg
- 10mM*1mLinDMSO
- 1mg
- 10
- 50
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1000mg
- 1g
- Manufactureraablocks
- Product numberAA001T7C
- Product descriptionAT-56 ≥98%(HPLC)
- Packaging25mg
- Price$55
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001T7C
- Product descriptionAT-56 ≥98%(HPLC)
- Packaging50mg
- Price$93
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001T7C
- Product descriptionAT-56 ≥98%(HPLC)
- Packaging5mg
- Price$15
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001T7C
- Product descriptionAT-56 ≥98%(HPLC)
- Packaging100mg
- Price$158
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberR16072
- Product descriptionAT-56 98%
- Packaging100MG
- Price$295
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberR16072
- Product descriptionAT-56 98%
- Packaging25MG
- Price$110
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number0268CT
- Product descriptionCID11741525
- Packaging1mg
- Price$139
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001044
- Product description4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-(4-(2H-TETRAZOL-5-YL)BUTYL)-PIPERIDINE 95.00%
- Packaging1MG
- Price$145.95
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001044
- Product description4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-(4-(2H-TETRAZOL-5-YL)BUTYL)-PIPERIDINE 95.00%
- Packaging5MG
- Price$500.06
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5445
- Product descriptionAT 56
- Packaging10mg
- Price$314
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5445
- Product descriptionAT 56
- Packaging50mg
- Price$1373
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberSLK-S9678
- Product descriptionAT-56 98.52%
- Packaging25mg
- Price$371
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-S9678
- Product descriptionAT-56 98.52%
- Packaging5mg
- Price$123
- Updated2026-05-26
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181201
- Product descriptionAT-56 >98%
- Packaging100mg
- Price$838.1
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181201
- Product descriptionAT-56 >98%
- Packaging250mg
- Price$1504.5
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb181201
- Product descriptionAT-56 >98%
- Packaging1000mg
- Price$2395.3
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001T7C | AT-56 ≥98%(HPLC) | 25mg | $55 | 2026-05-28 | Buy |
| aablocks | AA001T7C | AT-56 ≥98%(HPLC) | 50mg | $93 | 2026-05-28 | Buy |
| aablocks | AA001T7C | AT-56 ≥98%(HPLC) | 5mg | $15 | 2026-05-28 | Buy |
| aablocks | AA001T7C | AT-56 ≥98%(HPLC) | 100mg | $158 | 2026-05-28 | Buy |
| ACHEMBLOCK | R16072 | AT-56 98% | 100MG | $295 | 2026-05-27 | Buy |
| ACHEMBLOCK | R16072 | AT-56 98% | 25MG | $110 | 2026-05-27 | Buy |
| AK Scientific | 0268CT | CID11741525 | 1mg | $139 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001044 | 4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-(4-(2H-TETRAZOL-5-YL)BUTYL)-PIPERIDINE 95.00% | 1MG | $145.95 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001044 | 4-(5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-(4-(2H-TETRAZOL-5-YL)BUTYL)-PIPERIDINE 95.00% | 5MG | $500.06 | 2021-12-16 | Buy |
| ApexBio Technology | B5445 | AT 56 | 10mg | $314 | 2026-05-06 | Buy |
| ApexBio Technology | B5445 | AT 56 | 50mg | $1373 | 2026-05-06 | Buy |
| Arctom | SLK-S9678 | AT-56 98.52% | 25mg | $371 | 2026-05-26 | Buy |
| Arctom | SLK-S9678 | AT-56 98.52% | 5mg | $123 | 2026-05-26 | Buy |
| Biorbyt Ltd | orb181201 | AT-56 >98% | 100mg | $838.1 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181201 | AT-56 >98% | 250mg | $1504.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181201 | AT-56 >98% | 1000mg | $2395.3 | 2021-12-16 | Buy |
Properties
Boiling point :620.4±65.0 °C(Predicted)
Density :1.216±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: soluble10mg/mL, clear
pka :4.99±0.10(Predicted)
form :powder
color :white to beige
InChI :1S/C25H27N5/c1-3-9-22-19(7-1)12-13-20-8-2-4-10-23(20)25(22)21-14-17-30(18-15-21)16-6-5-11-24-26-28-29-27-24/h1-4,7-10,12-13H,5-6,11,14-18H2,(H,26,27,28,29)
InChIKey :LQNGMDUIRLSESZ-UHFFFAOYSA-N
SMILES :N1(CCCCC2=NNN=N2)CC/C(=C2/C3=CC=CC=C3C=CC3=CC=CC=C3/2)/CC1
Density :1.216±0.06 g/cm3(Predicted)
storage temp. :Inert atmosphere,Store in freezer, under -20°C
solubility :DMSO: soluble10mg/mL, clear
pka :4.99±0.10(Predicted)
form :powder
color :white to beige
InChI :1S/C25H27N5/c1-3-9-22-19(7-1)12-13-20-8-2-4-10-23(20)25(22)21-14-17-30(18-15-21)16-6-5-11-24-26-28-29-27-24/h1-4,7-10,12-13H,5-6,11,14-18H2,(H,26,27,28,29)
InChIKey :LQNGMDUIRLSESZ-UHFFFAOYSA-N
SMILES :N1(CCCCC2=NNN=N2)CC/C(=C2/C3=CC=CC=C3C=CC3=CC=CC=C3/2)/CC1
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
Prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to produce PGD2. PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGDS have been identified, namely the lipocalin-type enzyme (β-trace, L-PGDS) and the hematopoietic-type enzyme (H-PGDS). L-PGDS is localized in the central nervous system, male genital organs of various mammals, and the human heart and is a major protein in human cerebrospinal fluid (CSF). AT-56 is a selective, competitive, and highly bioavailable inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) with a Ki value of 75 μM. It inhibits the production of PGD2 by L-PGDS-expressing cells purified from human CSF and recombinant mouse cells with an IC50 value of 95 μM. At concentrations as high as 100 μM in vitro or 30 mg/kg in vivo, AT-56 does not affect the production of PGE2, PGF2α, or H-PGDS-catalyzed PGD2. At 10 mg/kg AT-56, the numbers of total cells, infiltrating eosinophils, and monocytes in bronchoalveolar lavage fluid of L-PGDS transgenic mice were decreased to 23, 6, and 41% of controls, respectively.More related product prices
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