AY 9944
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- $30 - $2200
- Product name: AY 9944
- CAS: 366-93-8
- MF: C22H30Cl4N2
- MW: 464.3
- EINECS:
- MDL Number:MFCD01734586
- Synonyms:1,4-cyclohexanebis(methylamine),n,n’-bis(2-chlorobenzyl)-,dihydrochloride,(e ;4-cyclohexanebis(methylamine),n,n’-bis(o-chlorobenzyl)-dihydrochloride ;4-cyclohexanedimethanamine,n,n’-bis((2-chlorophenyl)methyl)-dihydrochlor ;trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexanedihydrochloride ;N-[(2-chlorophenyl)methyl]-1-[4-[[(2-chlorophenyl)methylamino]methyl]cyclohexyl]methanamine dihydrochloride;1,1'-((1r,4r)-cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine);1,4-BIS(2-CHLOROBENZYLAMINOMETHYL)CYCLOHEXANE DIHYDROCHLORIDE;AY99442HCl
39 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- ApexBio Technology
- Biosynth
- Cayman Chemical
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Thermo Scientific Chemicals
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 1g
- 1 unit
- Manufactureraablocks
- Product numberAA00C5N5
- Product descriptiontrans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98%
- Packaging1mg
- Price$30
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C5N5
- Product descriptiontrans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98%
- Packaging5mg
- Price$58
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C5N5
- Product descriptiontrans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98%
- Packaging10mg
- Price$98
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C5N5
- Product descriptiontrans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98%
- Packaging50mg
- Price$320
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00C5N5
- Product descriptiontrans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98%
- Packaging25mg
- Price$204
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238259
- Product descriptionAY 9944 98%
- Packaging25MG
- Price$505
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberZ238259
- Product descriptionAY 9944 98%
- Packaging100MG
- Price$1275
- Updated2026-05-27
- Buy
- ManufacturerApexBio Technology
- Product numberA8658
- Product descriptionAY 9944 dihydrochloride
- Packaging25mg
- Price$457
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8658
- Product descriptionAY 9944 dihydrochloride
- Packaging25mg
- Price$435
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8658
- Product descriptionAY 9944 dihydrochloride
- Packaging5mg
- Price$142
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA8658
- Product descriptionAY 9944 dihydrochloride
- Packaging10mg
- Price$228
- Updated2026-05-06
- Buy
- ManufacturerBiosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging5mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging1mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging10mg
- Price$400
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging25mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerBiosynth
- Product numberFA18037
- Product descriptionAY 9944
- Packaging50mg
- Price$1250
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00C5N5 | trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98% | 1mg | $30 | 2026-05-28 | Buy |
| aablocks | AA00C5N5 | trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98% | 5mg | $58 | 2026-05-28 | Buy |
| aablocks | AA00C5N5 | trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98% | 10mg | $98 | 2026-05-28 | Buy |
| aablocks | AA00C5N5 | trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98% | 50mg | $320 | 2026-05-28 | Buy |
| aablocks | AA00C5N5 | trans-1,1'-(Cyclohexane-1,4-diyl)bis(N-(2-chlorobenzyl)methanamine) dihydrochloride 98% | 25mg | $204 | 2026-05-28 | Buy |
| ACHEMBLOCK | Z238259 | AY 9944 98% | 25MG | $505 | 2026-05-27 | Buy |
| ACHEMBLOCK | Z238259 | AY 9944 98% | 100MG | $1275 | 2026-05-27 | Buy |
| ApexBio Technology | A8658 | AY 9944 dihydrochloride | 25mg | $457 | 2026-05-06 | Buy |
| ApexBio Technology | A8658 | AY 9944 dihydrochloride | 25mg | $435 | 2021-12-16 | Buy |
| ApexBio Technology | A8658 | AY 9944 dihydrochloride | 5mg | $142 | 2026-05-06 | Buy |
| ApexBio Technology | A8658 | AY 9944 dihydrochloride | 10mg | $228 | 2026-05-06 | Buy |
| Biosynth | FA18037 | AY 9944 | 5mg | $250 | 2021-12-16 | Buy |
| Biosynth | FA18037 | AY 9944 | 1mg | $100 | 2021-12-16 | Buy |
| Biosynth | FA18037 | AY 9944 | 10mg | $400 | 2021-12-16 | Buy |
| Biosynth | FA18037 | AY 9944 | 25mg | $750 | 2021-12-16 | Buy |
| Biosynth | FA18037 | AY 9944 | 50mg | $1250 | 2021-12-16 | Buy |
Properties
Melting point :288-293.5 °C(lit.)
storage temp. :2-8°C
solubility :DMSO: 14 mg/mL
form :White solid
color :white
Water Solubility :Soluble to 50 mM in water
Sensitive :Hygroscopic
InChI :1S/C22H28Cl2N2.2ClH/c23-21-7-3-1-5-19(21)15-25-13-17-9-11-18(12-10-17)14-26-16-20-6-2-4-8-22(20)24;;/h1-8,17-18,25-26H,9-16H2;2*1H
InChIKey :NRVIEWRSGDDWHP-UHFFFAOYSA-N
SMILES :[Cl-].[Cl-].Clc1c(cccc1)CNCC2CCC(CC2)CNCc3c(cccc3)Cl.[H+].[H+]
storage temp. :2-8°C
solubility :DMSO: 14 mg/mL
form :White solid
color :white
Water Solubility :Soluble to 50 mM in water
Sensitive :Hygroscopic
InChI :1S/C22H28Cl2N2.2ClH/c23-21-7-3-1-5-19(21)15-25-13-17-9-11-18(12-10-17)14-26-16-20-6-2-4-8-22(20)24;;/h1-8,17-18,25-26H,9-16H2;2*1H
InChIKey :NRVIEWRSGDDWHP-UHFFFAOYSA-N
SMILES :[Cl-].[Cl-].Clc1c(cccc1)CNCC2CCC(CC2)CNCc3c(cccc3)Cl.[H+].[H+]
Safety Information
| Symbol(GHS): |
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| Signal word: | Danger | ||||||||||||||
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Description
AY 9944 prevents cholesterol biosynthesis by inhibiting the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50 = 13 nM), which interferes with the conversion of 7-dehydro cholesterol to cholesterol. Furthermore, by upregulating the expression of DHCR7, AY 9944 can block Hedgehog signaling at the level of Smoothened or by loss of Suppressor of Fused. AY 9944 inhibition of DHCR7 has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome, a disorder brought about by mutations in the DHCR7 gene, in animal models. However, AY 9944 is highly teratogenic, producing congenital defects in offspring when fed to pregnant animals.Related product price
- AY 9944
$30-2200 - 2549-93-1
$13-1309 - 2-Chlorobenzylamine
$4-4312.77
Suppliers and manufacturers
DAYANG CHEM (HANGZHOU) CO.,LTD
J & K SCIENTIFIC LTD.
3B Pharmachem (Wuhan) International Co.,Ltd.
Chemsky (shanghai) International Co.,Ltd
EMMX Biotechnology LLC
Shenzhen Polymeri Biochemical Technology Co., Ltd.
BOC Sciences
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
