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ChemicalBook >> CAS DataBase List >> Aftin-4

Aftin-4

$36 - $2100
Product name: Aftin-4
CAS: 866893-90-5
MF: C20H28N6O
MW: 368.48
EINECS:-0
MDL Number:MFCD30187584
Synonyms:Aftin-4;AFTIN-4;AFTIN 4;AFTIN4;N6-methyl-(R)-roscovitine;1-Butanol, 2-[[9-(1-methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-, (2R)-;Aftin-4 >=98% (HPLC);(R)-2-((6-(Benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol;β-amyloid peptide,inhibit,Abeta,Amyloid-β,Aftin-4,Inhibitor;Aftin-4, 10 mM in DMSO

Price40 Properties Safety Information Description

40 prices

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Brand

aablocks
ACHEMBLOCK
Adipogen Life Sciences
AK Scientific
American Custom Chemicals Corporation
Cayman Chemical
Chemenu
ChemScene
Crysdot
DC Chemicals
Sigma-Aldrich
TRC
Usbiological

Package

1mg
2mg
2.5mg
5mg
10mM*1mLinDMSO
10mg
25mg
50mg
100mg
200mg
250mg
1G

Manufactureraablocks
Product numberAA01EAZF
Product description(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98
Packaging5mg
Price$61
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EAZF
Product description(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%
Packaging10mg
Price$80
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EAZF
Product description(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%
Packaging25mg
Price$104
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EAZF
Product description(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%
Packaging50mg
Price$175
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EAZF
Product description(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98
Packaging100mg
Price$303
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EAZF
Product description(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98
Packaging200mg
Price$404
Updated2026-05-30
Buy

Manufactureraablocks
Product numberAA01EAZF
Product description(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%
Packaging2mg
Price$44
Updated2026-05-30
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Manufactureraablocks
Product numberAA01EAZF
Product description(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%
Packaging1mg
Price$36
Updated2026-05-30
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ManufacturerACHEMBLOCK
Product numberQ65769
Product description(R)-2-((6-(benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol 98%
Packaging1G
Price$1035
Updated2026-05-27
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ManufacturerACHEMBLOCK
Product numberQ65769
Product description(R)-2-((6-(benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol 98%
Packaging100MG
Price$205
Updated2026-05-27
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ManufacturerAdipogen Life Sciences
Product numberAG-MR-C0014-M005
Product descriptionAftin-4 ≥98%(HPLC)
Packaging5mg
Price$190
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-MR-C0014-M025
Product descriptionAftin-4 ≥98%(HPLC)
Packaging25mg
Price$640
Updated2026-05-06
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ManufacturerAdipogen Life Sciences
Product numberAG-MR-C0014-M001
Product descriptionAftin-4 ≥98%(HPLC)
Packaging1mg
Price$55
Updated2026-05-06
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ManufacturerAK Scientific
Product number8855CN
Product descriptionAftin-4
Packaging5mg
Price$324
Updated2021-12-16
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ManufacturerAmerican Custom Chemicals Corporation
Product numberINB0009881
Product descriptionAFTIN-4 95.00%
Packaging5MG
Price$454.49
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number27341
Product descriptionAftin-4 ≥98%
Packaging25mg
Price$653
Updated2026-04-30
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA01EAZF	(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98	5mg	$61	2026-05-30	Buy
aablocks	AA01EAZF	(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%	10mg	$80	2026-05-30	Buy
aablocks	AA01EAZF	(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%	25mg	$104	2026-05-30	Buy
aablocks	AA01EAZF	(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%	50mg	$175	2026-05-30	Buy
aablocks	AA01EAZF	(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98	100mg	$303	2026-05-30	Buy
aablocks	AA01EAZF	(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98	200mg	$404	2026-05-30	Buy
aablocks	AA01EAZF	(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%	2mg	$44	2026-05-30	Buy
aablocks	AA01EAZF	(2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol 98%	1mg	$36	2026-05-30	Buy
ACHEMBLOCK	Q65769	(R)-2-((6-(benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol 98%	1G	$1035	2026-05-27	Buy
ACHEMBLOCK	Q65769	(R)-2-((6-(benzyl(methyl)amino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol 98%	100MG	$205	2026-05-27	Buy
Adipogen Life Sciences	AG-MR-C0014-M005	Aftin-4 ≥98%(HPLC)	5mg	$190	2026-05-06	Buy
Adipogen Life Sciences	AG-MR-C0014-M025	Aftin-4 ≥98%(HPLC)	25mg	$640	2026-05-06	Buy
Adipogen Life Sciences	AG-MR-C0014-M001	Aftin-4 ≥98%(HPLC)	1mg	$55	2026-05-06	Buy
AK Scientific	8855CN	Aftin-4	5mg	$324	2021-12-16	Buy
American Custom Chemicals Corporation	INB0009881	AFTIN-4 95.00%	5MG	$454.49	2021-12-16	Buy
Cayman Chemical	27341	Aftin-4 ≥98%	25mg	$653	2026-04-30	Buy

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Properties

storage temp. :-20°C
solubility :DMSO: soluble
form :powder
color :white to beige
InChI :1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1
InChIKey :YPYWONAECUVKHY-MRXNPFEDSA-N
SMILES :[n]1(c2nc(nc(c2nc1)N(Cc3ccccc3)C)N[C@@H](CO)CC)C(C)C

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning		P264, P270, P301+P312, P330, P501

Precautionary statements:

P280	Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Aftin-4 is an inducer of amyloid-β (1-42) (Aβ42). It selectively increases extracellular Aβ42 over Aβ40 production in N2a-AβPP695 cells when used at concentrations ranging from 1 to 100 mM. In vivo, aftin-4 (3-20 nmol/animal, i.c.v.) increases hippocampal Aβ42 content, lipid peroxidation, and production of the pro-inflammatory cytokines IL-1β, IL-6, and TNF-α in mice. It also induces spatial working and spatial reference memory deficits in mice, effects that are reversed by co-administration of the γ-secretase inhibitor BMS-299,897.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

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Aftin-4 CAS:866893-90-5

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Aftin-4

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