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ChemicalBook >> CAS DataBase List >> BETA-LAPACHONE

BETA-LAPACHONE

BETA-LAPACHONE price.
  • $30 - $1478
  • Product name: BETA-LAPACHONE
  • CAS: 4707-32-8
  • MF: C15H14O3
  • MW: 242.27
  • EINECS:
  • MDL Number:MFCD01712233
  • Synonyms:BETA-LAPACHONE;2-b)pyran-5,6-dione,3,4-dihydro-2,2-dimethyl-2h-naphtho( ;B-LAPACHONE,2,2-DIMETHYL-3,4-DIHYDRO-2H-BENZO[H]CHROMENE-5,6-DIONE;3,4-DIHYDRO-2,2-DIMETHYL-2H-NAPHTHO[1,2-B]PYRAN-5,6-DIONE;3,4-DIHYDRO-2,2-DIMETHYL-2H-NAPHTHOL[1,2-B]PYRAN-5,6-DIONE;2,2-Dimethyl-3,4,5,6-tetrahydro-2H-naphtho[1,2-b]pyran-5,6-dione;2,2-dimethyl-3,4-dihydrobenzo[h]chromene-5,6-dione;β-Lapachone (90%)
39 prices
Selected condition:
Brand
  • AHH
  • AK Scientific
  • Alfa Aesar
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 25mg
  • 10
  • 250mg
  • 1g
  • 50
  • 10mM(in 1mL DMSO)
  • 5mg
  • 10mg
  • 0.05g
  • 50mg
  • 100MG
  • ManufacturerAHH
  • Product numberMT-09703
  • Product description3,4-Dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6dione 98%
  • Packaging0.05g
  • Price$436
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2265AH
  • Product descriptionBeta-Lapachone
  • Packaging10mg
  • Price$91
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number2265AH
  • Product descriptionBeta-Lapachone
  • Packaging50mg
  • Price$274
  • Updated2021-12-16
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberJ67308
  • Product descriptionbeta-Lapachone, 98%
  • Packaging5mg
  • Price$152
  • Updated2023-06-20
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000122
  • Product descriptionBETA-LAPACHONE 95.00%
  • Packaging5MG
  • Price$425.5
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000122
  • Product descriptionBETA-LAPACHONE 95.00%
  • Packaging10MG
  • Price$451
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberINB0000122
  • Product descriptionBETA-LAPACHONE 95.00%
  • Packaging100MG
  • Price$732
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2290
  • Product descriptionBeta-Lapachone
  • Packaging10mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2290
  • Product descriptionBeta-Lapachone
  • Packaging10mM(in 1mL DMSO)
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB2290
  • Product descriptionBeta-Lapachone
  • Packaging50mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0149
  • Product descriptionBeta-Lapachone
  • Packaging5mg
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0149
  • Product descriptionBeta-Lapachone
  • Packaging10mg
  • Price$153
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0149
  • Product descriptionBeta-Lapachone
  • Packaging50mg
  • Price$370
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS698211
  • Product descriptionβ-Lapachone ≥98%
  • Packaging5mg
  • Price$30
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS698211
  • Product descriptionβ-Lapachone ≥98%
  • Packaging10mg
  • Price$51
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS698211
  • Product descriptionβ-Lapachone ≥98%
  • Packaging50mg
  • Price$181
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AHH MT-09703 3,4-Dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6dione 98% 0.05g $436 2021-12-16 Buy
AK Scientific 2265AH Beta-Lapachone 10mg $91 2021-12-16 Buy
AK Scientific 2265AH Beta-Lapachone 50mg $274 2021-12-16 Buy
Alfa Aesar J67308 beta-Lapachone, 98% 5mg $152 2023-06-20 Buy
American Custom Chemicals Corporation INB0000122 BETA-LAPACHONE 95.00% 5MG $425.5 2021-12-16 Buy
American Custom Chemicals Corporation INB0000122 BETA-LAPACHONE 95.00% 10MG $451 2021-12-16 Buy
American Custom Chemicals Corporation INB0000122 BETA-LAPACHONE 95.00% 100MG $732 2021-12-16 Buy
ApexBio Technology B2290 Beta-Lapachone 10mg $60 2021-12-16 Buy
ApexBio Technology B2290 Beta-Lapachone 10mM(in 1mL DMSO) $65 2021-12-16 Buy
ApexBio Technology B2290 Beta-Lapachone 50mg $210 2021-12-16 Buy
Apolloscientific BISN0149 Beta-Lapachone 5mg $87 2021-12-16 Buy
Apolloscientific BISN0149 Beta-Lapachone 10mg $153 2021-12-16 Buy
Apolloscientific BISN0149 Beta-Lapachone 50mg $370 2021-12-16 Buy
Arctom AS698211 β-Lapachone ≥98% 5mg $30 2021-12-16 Buy
Arctom AS698211 β-Lapachone ≥98% 10mg $51 2021-12-16 Buy
Arctom AS698211 β-Lapachone ≥98% 50mg $181 2021-12-16 Buy

Properties

Melting point :>110°C (dec.)
Boiling point :381.4±42.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Inert atmosphere,Room Temperature
solubility :Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
form :Orange to brown solid.
color :Orange
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code
InChIKey :QZPQTZZNNJUOLS-UHFFFAOYSA-N
LogP :2.820 (est)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

β-Lapachone is a natural quinone with diverse anti-cancer and anti-inflammatory effects. It inhibits topoisomerase I at 25 μM and transglutaminase (IC50 = 5 μM). In cancer cells which overexpress NAD(P)H:quinone oxidoreductase, β-lapachone is reduced to β-lapachone hydroquinone, which generates reactive oxygen species during its reversion to β-lapachone. This process sensitizes cancer cells to radiation, suppresses NF-κB activation, and drives apoptosis.

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