BI-9564
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- $25 - $2590
- Product name: BI-9564
- CAS: 1883429-22-8
- MF: C20H23N3O3
- MW: 353.41
- EINECS:
- MDL Number:MFCD30182324
- Synonyms:BI-9564;4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one;BI-9564 (BI 9564;CS-2421;2,7-Naphthyridin-1(2H)-one, 4-[4-[(dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-;BI-9564 >=97% (HPLC);BI-9564,Inhibitor,Epigenetic Reader Domain,inhibit;4-(4-((Dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one
57 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Ambeed
- American Custom Chemicals Corporation
- ApexBio Technology
- Biosynth
- BroadPharm
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
Package
- 10mM*1mLinDMSO
- 500μg
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50MG
- 100MG
- 10
- 200mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA00ABOC
- Product description4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one 98%
- Packaging1mg
- Price$25
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABOC
- Product description4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one 98%
- Packaging5mg
- Price$35
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABOC
- Product description4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one 98%
- Packaging10mg
- Price$64
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABOC
- Product description4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one 98%
- Packaging25mg
- Price$144
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228971
- Product descriptionBI-9564 97.00%
- Packaging50MG
- Price$400
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228971
- Product descriptionBI-9564 97.00%
- Packaging100MG
- Price$675
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number0909EF
- Product description4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One
- Packaging10mg
- Price$336
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number0909EF
- Product description4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One
- Packaging1mg
- Price$158
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA429986
- Product descriptionBI-9564 98+%
- Packaging50mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA429986
- Product descriptionBI-9564 98+%
- Packaging10mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA429986
- Product descriptionBI-9564 98+%
- Packaging25mg
- Price$111
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA429986
- Product descriptionBI-9564 98+%
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0004766
- Product description4-(4-DIMETHYLAMINOMETHYL-2,5-DIMETHOXY-PHENYL)-2-METHYL-2H-[2,7]NAPHTHYRIDIN-1-ONE 95.00%
- Packaging5MG
- Price$505.15
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6184
- Product descriptionBI-9564
- Packaging50mg
- Price$819
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6184
- Product descriptionBI-9564
- Packaging100mg
- Price$1244
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6184
- Product descriptionBI-9564
- Packaging200mg
- Price$2284
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00ABOC | 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one 98% | 1mg | $25 | 2026-05-28 | Buy |
| aablocks | AA00ABOC | 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one 98% | 5mg | $35 | 2026-05-28 | Buy |
| aablocks | AA00ABOC | 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one 98% | 10mg | $64 | 2026-05-28 | Buy |
| aablocks | AA00ABOC | 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one 98% | 25mg | $144 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y228971 | BI-9564 97.00% | 50MG | $400 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228971 | BI-9564 97.00% | 100MG | $675 | 2026-05-27 | Buy |
| AK Scientific | 0909EF | 4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One | 10mg | $336 | 2021-12-16 | Buy |
| AK Scientific | 0909EF | 4-[4-[(Dimethylamino)methyl]-2,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One | 1mg | $158 | 2021-12-16 | Buy |
| Ambeed | A429986 | BI-9564 98+% | 50mg | $145 | 2021-12-16 | Buy |
| Ambeed | A429986 | BI-9564 98+% | 10mg | $85 | 2021-12-16 | Buy |
| Ambeed | A429986 | BI-9564 98+% | 25mg | $111 | 2021-12-16 | Buy |
| Ambeed | A429986 | BI-9564 98+% | 5mg | $65 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0004766 | 4-(4-DIMETHYLAMINOMETHYL-2,5-DIMETHOXY-PHENYL)-2-METHYL-2H-[2,7]NAPHTHYRIDIN-1-ONE 95.00% | 5MG | $505.15 | 2021-12-16 | Buy |
| ApexBio Technology | B6184 | BI-9564 | 50mg | $819 | 2021-12-16 | Buy |
| ApexBio Technology | B6184 | BI-9564 | 100mg | $1244 | 2021-12-16 | Buy |
| ApexBio Technology | B6184 | BI-9564 | 200mg | $2284 | 2021-12-16 | Buy |
Properties
storage temp. :Store at -20°C
solubility :≥8.82 mg/mL in DMSO with ultrasonic,≥8.32 mg/mL in EtOH with ultrasonic,insoluble in H2O
form :crystalline solid
color :White to off-white
InChI :InChI=1S/C20H23N3O3/c1-22(2)11-13-8-19(26-5)15(9-18(13)25-4)17-12-23(3)20(24)16-10-21-7-6-14(16)17/h6-10,12H,11H2,1-5H3
InChIKey :BJFSUDWKXGMUKA-UHFFFAOYSA-N
SMILES :C1(=O)C2C(=CC=NC=2)C(C2=CC(OC)=C(CN(C)C)C=C2OC)=CN1C
solubility :≥8.82 mg/mL in DMSO with ultrasonic,≥8.32 mg/mL in EtOH with ultrasonic,insoluble in H2O
form :crystalline solid
color :White to off-white
InChI :InChI=1S/C20H23N3O3/c1-22(2)11-13-8-19(26-5)15(9-18(13)25-4)17-12-23(3)20(24)16-10-21-7-6-14(16)17/h6-10,12H,11H2,1-5H3
InChIKey :BJFSUDWKXGMUKA-UHFFFAOYSA-N
SMILES :C1(=O)C2C(=CC=NC=2)C(C2=CC(OC)=C(CN(C)C)C=C2OC)=CN1C
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
BI-9564 is a selective inhibitor of BRD9 and BRD7 bromodomains (Kds = 14.1 and 239 nM; IC50s = 75 nM and 3.4 μM, respectively) that demonstrates cellular activity by semi-quantitative FRAP assay with ~90% inhibition of BRD9 and BRD7 at 0.1 μM and 1 μM, respectively. It does not bind to other bromodomain-containing BET family members (IC50s >100 μM as assessed by AlphaScreen), kinases, or G protein-coupled receptors and shows off-target selectivity only to the CECR2 bromodomain in in vitro ITC assays (Kd = 258 nM), but not in cell-based assays at concentrations up to 1 μM. BI-9564 has been shown to inhibit the growth of EOL-1 AML cells both in vitro (EC50 = 800 nM) and in a disseminated mouse model of AML (180 mg/kg/day). See the Structural Genomics Consortium (SGC) website for more information.Related product price
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