BIO
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- $30 - $1440
- Product name: BIO
- CAS: 667463-62-9
- MF: C16H10BrN3O2
- MW: 356.17
- EINECS:
- MDL Number:MFCD08705318
- Synonyms:2H-Indol-2-one, 6-broMo-3-[(3E)-1,3-dihydro-3-(hydroxyiMino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)-;6BIO;6-bromoindirubin-3-oxime;GSK3 Inhibitor IX1;BIO(GSK-3 Inhibitor IX;BIO (SM04554);InSolution? GSK-3 Inhibitor IX ;(2E,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
44 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TCI Chemical
- Thermo Scientific Chemicals
- TRC
- Usbiological
Package
- 10mM(in1mLDMSO)
- 1mg
- 30mg
- 250mg
- 1g
- 10mM(in 1mL DMSO)
- 500μg
- 5mg
- 10mg
- 25mg
- 50mg
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0056-M001
- Product description6BIO ≥98%(NMR)
- Packaging1mg
- Price$30
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0056-M005
- Product description6BIO ≥98%(NMR)
- Packaging5mg
- Price$65
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0056-M005
- Product description6BIO ≥98%(NMR)
- Packaging5mg
- Price$65
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0019-M010
- Product description6BIO ≥99%(NMR)
- Packaging10mg
- Price$130
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0056-M025
- Product description6BIO ≥98%(NMR)
- Packaging25mg
- Price$260
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0019-M050
- Product description6BIO ≥99%(NMR)
- Packaging50mg
- Price$480
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-MR-C0019-M050
- Product description6BIO ≥99%(NMR)
- Packaging50mg
- Price$490
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number2268AH
- Product description(3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one
- Packaging10mg
- Price$218
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2268AH
- Product description(3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3InhibitorIX(BIO)
- Packaging50mg
- Price$399
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3 Inhibitor IX (BIO)
- Packaging50mg
- Price$399
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3InhibitorIX(BIO)
- Packaging10mg
- Price$103
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3 Inhibitor IX (BIO)
- Packaging10mg
- Price$103
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3InhibitorIX(BIO)
- Packaging10mM(in 1mL DMSO)
- Price$108
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1538
- Product descriptionGSK-3 Inhibitor IX (BIO)
- Packaging10mM(in1mLDMSO)
- Price$108
- Updated2026-05-06
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1693
- Product descriptionBIO-GSK-3inhibitorIX|6-Bromoindirubin-3'-oxime 98%
- Packaging50mg
- Price$368.5
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-0056-M001 | 6BIO ≥98%(NMR) | 1mg | $30 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0056-M005 | 6BIO ≥98%(NMR) | 5mg | $65 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0056-M005 | 6BIO ≥98%(NMR) | 5mg | $65 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-MR-C0019-M010 | 6BIO ≥99%(NMR) | 10mg | $130 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0056-M025 | 6BIO ≥98%(NMR) | 25mg | $260 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-MR-C0019-M050 | 6BIO ≥99%(NMR) | 50mg | $480 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-MR-C0019-M050 | 6BIO ≥99%(NMR) | 50mg | $490 | 2026-05-06 | Buy |
| AK Scientific | 2268AH | (3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one | 10mg | $218 | 2021-12-16 | Buy |
| AK Scientific | 2268AH | (3Z)-6-Bromo-3-[(3E)-3-hydroxyimino-1H-indol-2-ylidene]-1H-indol-2-one | 50mg | $640 | 2021-12-16 | Buy |
| ApexBio Technology | B1538 | GSK-3InhibitorIX(BIO) | 50mg | $399 | 2021-12-16 | Buy |
| ApexBio Technology | B1538 | GSK-3 Inhibitor IX (BIO) | 50mg | $399 | 2026-05-06 | Buy |
| ApexBio Technology | B1538 | GSK-3InhibitorIX(BIO) | 10mg | $103 | 2021-12-16 | Buy |
| ApexBio Technology | B1538 | GSK-3 Inhibitor IX (BIO) | 10mg | $103 | 2026-05-06 | Buy |
| ApexBio Technology | B1538 | GSK-3InhibitorIX(BIO) | 10mM(in 1mL DMSO) | $108 | 2021-12-16 | Buy |
| ApexBio Technology | B1538 | GSK-3 Inhibitor IX (BIO) | 10mM(in1mLDMSO) | $108 | 2026-05-06 | Buy |
| Axon Medchem | Axon1693 | BIO-GSK-3inhibitorIX|6-Bromoindirubin-3'-oxime 98% | 50mg | $368.5 | 2021-12-16 | Buy |
Properties
Melting point :300°C(lit.)
Boiling point :554.3±50.0 °C(Predicted)
Density :1.80±0.1 g/cm3(Predicted)
RTECS :NM3241900
storage temp. :2-8°C
solubility :DMSO: >5 mg/mL
form :solid
pka :9.56±0.20(Predicted)
color :dark red
Sensitive :Air & Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,14,18H,(H,19,21)/b15-13-
InChIKey :WFRDXNRAUPBBTO-SQFISAMPSA-N
SMILES :Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2
Boiling point :554.3±50.0 °C(Predicted)
Density :1.80±0.1 g/cm3(Predicted)
RTECS :NM3241900
storage temp. :2-8°C
solubility :DMSO: >5 mg/mL
form :solid
pka :9.56±0.20(Predicted)
color :dark red
Sensitive :Air & Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChI :1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,14,18H,(H,19,21)/b15-13-
InChIKey :WFRDXNRAUPBBTO-SQFISAMPSA-N
SMILES :Brc1cc2c(cc1)\C(=C3\Nc4c(cccc4)C\3N=O)\C(=O)N2
Safety Information
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| Signal word: | Warning | ||||||||||||||||||||||||||||
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Description
BIO is a cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible, and ATP-competitive inhibitor of GSK3α/β (IC50 = 5 nM). Its specificity has been tested against various cyclin-dependent kinases (CDKs) (IC50s = 83, 300, 320, and 10,000 nM for Cdk5/p25, Cdk2/A, Cdk1/B, and Cdk4/D1, respectively). BIO was also tested for its specificity towards many other commonly studied kinases (IC50 ≥10 μM), including MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK. Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency in human and mouse embryonic stem cells (ESCs). BIO is reported to maintain self-renewal in human and mouse ESCs as well as induce the differentiation of neonatal cardiomyocytes.More related product prices
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