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ChemicalBook >> CAS DataBase List >> BIX-02565

BIX-02565

BIX-02565 price.
  • $36 - $1800
  • Product name: BIX-02565
  • CAS: 1311367-27-7
  • MF: C26H30N6O2
  • MW: 458.56
  • EINECS:
  • MDL Number:MFCD25976796
  • Synonyms:BIX-02565;(5R)-N-[1-[3-(Dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide;CS-2569;BIX-02565;BIX02565;Inhibitor,BIX02565,BIX-02565,Ribosomal S6 Kinase (RSK),S6K,BIX 02565,inhibit;1H-[1,4]Diazepino[1,2-a]indole-8-carboxamide, N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-, (5R)-;(R)-N-(1-(3-(Dimethylamino)propyl)-1H-benzo[d]imidazol-2-yl)-5-methyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide
21 prices
Selected condition:
Brand
  • Adipogen Life Sciences
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
Package
  • 500μg
  • 1mg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAdipogen Life Sciences
  • Product numberSYN-1228-M005
  • Product descriptionBIX02565 ≥95%
  • Packaging5mg
  • Price$205
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1228
  • Product descriptionBIX02565
  • Packaging5mg
  • Price$210
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN1228
  • Product descriptionBIX02565
  • Packaging50mg
  • Price$910
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1295
  • Product descriptionBIX02565
  • Packaging5mg
  • Price$238
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1295
  • Product descriptionBIX02565
  • Packaging10mM(in 1mL DMSO)
  • Price$275
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1295
  • Product descriptionBIX02565
  • Packaging10mg
  • Price$361
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1295
  • Product descriptionBIX02565
  • Packaging25mg
  • Price$523
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1295
  • Product descriptionBIX02565
  • Packaging50mg
  • Price$855
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19183
  • Product descriptionBIX 02565 ≥98%
  • Packaging500μg
  • Price$36
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19183
  • Product descriptionBIX 02565 ≥98%
  • Packaging1mg
  • Price$66
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19183
  • Product descriptionBIX 02565 ≥98%
  • Packaging5mg
  • Price$223
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1659
  • Product descriptionBIX02565 99.33%
  • Packaging2mg
  • Price$144
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1659
  • Product descriptionBIX02565 99.33%
  • Packaging5mg
  • Price$228
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1659
  • Product descriptionBIX02565 99.33%
  • Packaging10mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1659
  • Product descriptionBIX02565 99.33%
  • Packaging50mg
  • Price$1080
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-1659
  • Product descriptionBIX02565 99.33%
  • Packaging100mg
  • Price$1800
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences SYN-1228-M005 BIX02565 ≥95% 5mg $205 2021-12-16 Buy
AK Scientific SYN1228 BIX02565 5mg $210 2021-12-16 Buy
AK Scientific SYN1228 BIX02565 50mg $910 2021-12-16 Buy
ApexBio Technology B1295 BIX02565 5mg $238 2021-12-16 Buy
ApexBio Technology B1295 BIX02565 10mM(in 1mL DMSO) $275 2021-12-16 Buy
ApexBio Technology B1295 BIX02565 10mg $361 2021-12-16 Buy
ApexBio Technology B1295 BIX02565 25mg $523 2021-12-16 Buy
ApexBio Technology B1295 BIX02565 50mg $855 2021-12-16 Buy
Cayman Chemical 19183 BIX 02565 ≥98% 500μg $36 2024-03-01 Buy
Cayman Chemical 19183 BIX 02565 ≥98% 1mg $66 2024-03-01 Buy
Cayman Chemical 19183 BIX 02565 ≥98% 5mg $223 2024-03-01 Buy
ChemScene CS-1659 BIX02565 99.33% 2mg $144 2021-12-16 Buy
ChemScene CS-1659 BIX02565 99.33% 5mg $228 2021-12-16 Buy
ChemScene CS-1659 BIX02565 99.33% 10mg $360 2021-12-16 Buy
ChemScene CS-1659 BIX02565 99.33% 50mg $1080 2021-12-16 Buy
ChemScene CS-1659 BIX02565 99.33% 100mg $1800 2021-12-16 Buy

Properties

Density :1.32±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥22.95 mg/mL in DMSO; insoluble in H2O; ≥3.17 mg/mL in EtOH with gentle warming and ultrasonic
form :Powder
pka :12.30±0.40(Predicted)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility. Phosphorylation of the sodium-hydrogen exchanger (NHE) in cardiac tissue by RSK has been shown to activate NHE during cellular stresses, such as myocardial infarction, as a mechanism to maintain pH. BIX 02565 is a RSK2 inhibitor with an IC50 value of 1.1 nM. It also demonstrates off-target binding at multiple adrenergic receptor subtypes that are important for vascular tone and cardiac function (IC50s = 0.052-1.820 μM for adrenergic ɑ1A, ɑ1B, ɑ1D, ɑ2A, β2, and imidazoline I2 receptors. BIX 02565 can also inhibit LRRK2 and PRKD1 with IC50 values of 16 and 35 nM, respectively). In rats, BIX 02565 at 1, 3, and 10 mg/kg was shown to significantly decrease heart rate and mean arterial pressure.