STING R224 variant (human recombinant)
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- $649
- Product name: STING R224 variant (human recombinant)
- CAS:
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- MW: 0
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- Synonyms:STING R224 variant (human recombinant)
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Brand
- Cayman Chemical
Package
- 100μg
- ManufacturerCayman Chemical
- Product number23593
- Product descriptionSTING R224 variant (human, recombinant) ≥70%estimatedbySDS-PAGE
- Packaging100μg
- Price$649
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 23593 | STING R224 variant (human, recombinant) ≥70%estimatedbySDS-PAGE | 100μg | $649 | 2026-04-30 | Buy |
Properties
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Description
STING R224 variant (human, recombinant) contains amino acids 138-379 of the wild-type variant (R232) with lysine 224 substituted with arginine. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).1,2,3,4 The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project.5 The SNP variant H232 is found at a 13.7% frequency. The K224R mutation prevents ubiquitination of STING at position K224, a process which is essential for efficient cytosolic DNA-mediated signaling.6 Therefore, this mutation disrupts optimal STING trafficking, which inhibits TBK1-mediated IRF3 activation but not NF-κB activation.WARNING This product is not for human or veterinary use.More related product prices