Big Endothelin-1 (1-38) (human) (trifluoroacetate salt)
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- $436
- Product name: Big Endothelin-1 (1-38) (human) (trifluoroacetate salt)
- CAS:
- MF: C191H283F3N48O58S5
- MW: 4396.8977296
- EINECS:
- MDL Number:
- Synonyms:Big Endothelin-1 (1-38) (human) (trifluoroacetate salt)
1 prices
Selected condition：
Brand
- Cayman Chemical
Package
- 500μg
- ManufacturerCayman Chemical
- Product number24959
- Product descriptionBig Endothelin-1 (1-38) (human) (trifluoroacetate salt) ≥95%
- Packaging500μg
- Price$436
- Updated2026-04-30
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Cayman Chemical | 24959 | Big Endothelin-1 (1-38) (human) (trifluoroacetate salt) ≥95% | 500μg | $436 | 2026-04-30 | Buy |
Properties
solubility :Water: 1 mg/ml
Safety Information
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Description
Big endothelin-1 (BET-1) (1-38) is a peptide precursor of endothelin-1 (Item No. 24127) produced by vascular smooth muscle and endothelium.1 BET-1 is converted to endothelin-1 by endothelin-converting enzyme (ECE) and to endothelin-1 (1-31) by chymase.2 It is also converted to endothelin-1 (1-32) by matrix metalloproteinase-2 (MMP-2).1 BET-1 (50 pmol) induces vasoconstriction in isolated rat mesenteric arteries, an effect that is blocked by the MMP-2 antagonist TIMP-2. In vivo, BET-1 (0.1-10 nmol/kg, i.v.) dose-dependently increases blood pressure and bradycardia and leads to renal and hindquarter vasoconstriction in rats as well as abdominal constriction in mice (ED50 = 0.043 mg/kg), effects that are reversed or prevented by the ECE inhibitor phosphoramidon (Item No. 15113).3,4 It also induces mesenteric vasoconstriction in rats.3 Unlike endothelin-1, BET-1 (100 pmol/kg, i.v.) increases water and sodium excretion in rats independent of the endothelin A receptor.5WARNING This product is not for human or veterinary use.More related product prices