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ChemicalBook >> CAS DataBase List >> CGP 57380

CGP 57380

CGP 57380 price.
  • $22 - $5034
  • Product name: CGP 57380
  • CAS: 522629-08-9
  • MF: C11H9FN6
  • MW: 244.23
  • EINECS:
  • MDL Number:MFCD03861062
  • Synonyms:CGP 57380;CGP57380, N3-(4-fluorophenyl)-1h-pyrazolo[3,4-d]pyrimidine-3,4-diamine;MNK1 Inhibitor;N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine;CGP57380; CGP-57380;CS-1420;MNK1 Inhibitor - CAS 522629-08-9 - Calbiochem;P 57380
Price63 Properties Safety Information Description
63 prices
Selected condition：
Brand
  • aablocks
  • AK Scientific
  • Ambeed
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO(Solution)
  • 1000mg
  • 10mM(in1mLDMSO)
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10
  • 1
  • 10mM*1mLinDMSO
  • 50
  • 10mM(in 1mL DMSO)
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • Manufactureraablocks
  • Product numberAA00DA6V
  • Product descriptionN3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine 99%(HPLC)
  • Packaging1mg
  • Price$22
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DA6V
  • Product descriptionN3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine 99%(HPLC)
  • Packaging5mg
  • Price$49
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DA6V
  • Product descriptionN3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine 99%(HPLC)
  • Packaging10mg
  • Price$72
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DA6V
  • Product descriptionN3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine 99%(HPLC)
  • Packaging25mg
  • Price$123
  • Updated2026-05-28
  • Buy
  • ManufacturerAK Scientific
  • Product number2314AH
  • Product description3-N-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine
  • Packaging1mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151588
  • Product descriptionCGP 57380 98+%
  • Packaging5mg
  • Price$79
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151588
  • Product descriptionCGP 57380 98+%
  • Packaging1mg
  • Price$32
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151588
  • Product descriptionCGP 57380 98+%
  • Packaging10mg
  • Price$135
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151588
  • Product descriptionCGP 57380 98+%
  • Packaging50mg
  • Price$493
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151588
  • Product descriptionCGP 57380 98+%
  • Packaging100mg
  • Price$839
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151588
  • Product descriptionCGP 57380 98+%
  • Packaging250mg
  • Price$1678
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA151588
  • Product descriptionCGP 57380 98+%
  • Packaging1g
  • Price$5034
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000072
  • Product descriptionCGP 57380 95.00%
  • Packaging50MG
  • Price$1327.97
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000072
  • Product descriptionCGP 57380 95.00%
  • Packaging10MG
  • Price$721.59
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000072
  • Product descriptionCGP 57380 95.00%
  • Packaging1MG
  • Price$148.05
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB3570
  • Product descriptionCGP 57380
  • Packaging5mg
  • Price$89
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00DA6V N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine 99%(HPLC) 1mg $22 2026-05-28 Buy
aablocks AA00DA6V N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine 99%(HPLC) 5mg $49 2026-05-28 Buy
aablocks AA00DA6V N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine 99%(HPLC) 10mg $72 2026-05-28 Buy
aablocks AA00DA6V N3-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine 99%(HPLC) 25mg $123 2026-05-28 Buy
AK Scientific 2314AH 3-N-(4-Fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine 1mg $105 2021-12-16 Buy
Ambeed A151588 CGP 57380 98+% 5mg $79 2021-12-16 Buy
Ambeed A151588 CGP 57380 98+% 1mg $32 2021-12-16 Buy
Ambeed A151588 CGP 57380 98+% 10mg $135 2021-12-16 Buy
Ambeed A151588 CGP 57380 98+% 50mg $493 2021-12-16 Buy
Ambeed A151588 CGP 57380 98+% 100mg $839 2021-12-16 Buy
Ambeed A151588 CGP 57380 98+% 250mg $1678 2021-12-16 Buy
Ambeed A151588 CGP 57380 98+% 1g $5034 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000072 CGP 57380 95.00% 50MG $1327.97 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000072 CGP 57380 95.00% 10MG $721.59 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000072 CGP 57380 95.00% 1MG $148.05 2021-12-16 Buy
ApexBio Technology B3570 CGP 57380 5mg $89 2026-05-06 Buy
Next Last

Properties

storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
color :white to beige
InChI :1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)
InChIKey :UQPMANVRZYYQMD-UHFFFAOYSA-N
SMILES :Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CGP 57380 is a selective inhibitor of MAP kinase-interacting kinase 1 (MNK1) in vitro (IC50 = 2.2 μM), with no inhibitory activity against p38, JNK1, ERK1/2, PKC, or Src-like kinases. It blocks the phosphorylation of eIF4E in response to TNF-α, arsenite, anisomycin, PMA, or fetal calf serum in 293 cells (IC50 = 3 μM). CGP 57380 also dose-dependently inhibits TNF-α production in RAW 264.7 cells that have been co-treated with agonists for Toll-like receptor (TLR)2 (HKLM), TLR4 (LPS), TLR6/2 (FSL), TLR7 (imiquimod), or TLR9 (CpG DNA), presumably by inhibiting MNK1.

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Suppliers and manufacturers

3B Pharmachem (Wuhan) International Co.,Ltd. Shanghai Ennopharm Co., Ltd. Haoyuan Chemexpress Co., Ltd. Guangzhou Isun Pharmaceutical Co., Ltd AdooQ BioScience, LLC Bide Pharmatech Ltd. AdooQ Bioscience CHINA Hubei Jusheng Technology Co.,Ltd Sigma-Aldrich Shanghai Lollane Biological Technology Co.,Ltd.