CHIR-124
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- $36 - $1802
- Product name: CHIR-124
- CAS: 405168-58-3
- MF: C23H22ClN5O
- MW: 419.91
- EINECS:
- MDL Number:MFCD18917220
- Synonyms:CHIR-124;2(1H)-Quinolinone, 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylaMino]-3-(1H-benziMidazol-2-yl)-6-chloro-;4-[((3S)-1-Azabicyclo[2.2.2]oct-3-yl)amino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one;CS-2141;CHIR-124 (CHIR124;CHIR-124 USP/EP/BP;Platelet-derived growth factor receptor,PDGFR,CHIR-124,Checkpoint Kinase (Chk),CD135,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,inhibit,Apoptosis,Inhibitor,FLT3
26 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- TRC
Package
- 1mg
- 2mg
- 10mM(in 1mL DMSO)
- 5MG
- 2x5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product number2317AH
- Product description(S)-3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one
- Packaging25mg
- Price$478
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberCHM0032689
- Product descriptionCHIR-124 95.00%
- Packaging5MG
- Price$503.36
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8394
- Product descriptionCHIR-124
- Packaging5mg
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8394
- Product descriptionCHIR-124
- Packaging10mM(in 1mL DMSO)
- Price$95
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8394
- Product descriptionCHIR-124
- Packaging25mg
- Price$250
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA8394
- Product descriptionCHIR-124
- Packaging50mg
- Price$420
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60334
- Product descriptionCHIR-124 ≥98%
- Packaging10mg
- Price$278
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1636
- Product descriptionCHIR124 98%
- Packaging2mg
- Price$66
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1636
- Product descriptionCHIR124 98%
- Packaging2x5mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611603
- Product descriptionCHIR-124
- Packaging100mg
- Price$606.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611603
- Product descriptionCHIR-124
- Packaging250mg
- Price$912.9
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb611603
- Product descriptionCHIR-124
- Packaging1g
- Price$1802
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number16553
- Product descriptionCHIR124 ≥98%
- Packaging1mg
- Price$36
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16553
- Product descriptionCHIR124 ≥98%
- Packaging5mg
- Price$120
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16553
- Product descriptionCHIR124 ≥98%
- Packaging10mg
- Price$223
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number16553
- Product descriptionCHIR124 ≥98%
- Packaging25mg
- Price$341
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2317AH | (S)-3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one | 25mg | $478 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0032689 | CHIR-124 95.00% | 5MG | $503.36 | 2021-12-16 | Buy |
| ApexBio Technology | A8394 | CHIR-124 | 5mg | $88 | 2021-12-16 | Buy |
| ApexBio Technology | A8394 | CHIR-124 | 10mM(in 1mL DMSO) | $95 | 2021-12-16 | Buy |
| ApexBio Technology | A8394 | CHIR-124 | 25mg | $250 | 2021-12-16 | Buy |
| ApexBio Technology | A8394 | CHIR-124 | 50mg | $420 | 2021-12-16 | Buy |
| Arctom | CFN60334 | CHIR-124 ≥98% | 10mg | $278 | 2021-12-16 | Buy |
| Axon Medchem | Axon1636 | CHIR124 98% | 2mg | $66 | 2021-12-16 | Buy |
| Axon Medchem | Axon1636 | CHIR124 98% | 2x5mg | $154 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611603 | CHIR-124 | 100mg | $606.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611603 | CHIR-124 | 250mg | $912.9 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611603 | CHIR-124 | 1g | $1802 | 2021-12-16 | Buy |
| Cayman Chemical | 16553 | CHIR124 ≥98% | 1mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 16553 | CHIR124 ≥98% | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 16553 | CHIR124 ≥98% | 10mg | $223 | 2024-03-01 | Buy |
| Cayman Chemical | 16553 | CHIR124 ≥98% | 25mg | $341 | 2024-03-01 | Buy |
Properties
Density :1.46
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥10.5 mg/mL in DMSO; ≥2.61 mg/mL in EtOH with gentle warming
form :solid
pka :9.00±0.70(Predicted)
storage temp. :Store at -20°C
solubility :insoluble in H2O; ≥10.5 mg/mL in DMSO; ≥2.61 mg/mL in EtOH with gentle warming
form :solid
pka :9.00±0.70(Predicted)
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Checkpoint kinase 1 (Chk1) regulates S and G2-M phase cell cycle checkpoints in response to DNA damage. CHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC50 = 0.3 nM in vitro). It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher against Chk2 (IC50 = 0.7 μM). In synergy with topoisomerase I poisons or ionizing radiation, CHIR124 can inhibit the growth of p53-mutant solid tumor cells both in vitro and in a xenograft model, potentiating tumor apoptosis.More related product prices
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