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ChemicalBook >> CAS DataBase List >> CHR-6494

CHR-6494

CHR-6494 price.
  • $32 - $917
  • Product name: CHR-6494
  • CAS: 1333377-65-3
  • MF: C16H16N6
  • MW: 292.34
  • EINECS:
  • MDL Number:MFCD22666352
  • Synonyms:3-(1H-indazol-5-yl)-N-propyliMidazo[1,2-b]pyridazin-6-aMine;CHR-6494 3-(1H-indazol-5-yl)-N-propyliMidazo[1,2-b]pyridazin-6-aMine;3-(1H-Indazol-5-yl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine trifluoroacetate salt;3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate salt;CHR 6494 trifluoroacetate salt;CHR-6494 trifluoroacetate salt;Haspin Kinase Inhibitor, CHR-6494 ;CHR-6494
Price24 Properties Safety Information Description
24 prices
Selected condition：
Brand
  • AK Scientific
  • ApexBio Technology
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Sigma-Aldrich
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product numberSYN5064
  • Product descriptionCHR-6494TFASalt
  • Packaging10mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberSYN5064
  • Product descriptionCHR-6494TFASalt
  • Packaging50mg
  • Price$540
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3309
  • Product descriptionCHR-6494
  • Packaging5mg
  • Price$97
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3309
  • Product descriptionCHR-6494
  • Packaging10mg
  • Price$182
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3309
  • Product descriptionCHR-6494
  • Packaging50mg
  • Price$542
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3309
  • Product descriptionCHR-6494
  • Packaging100mg
  • Price$917
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number11478
  • Product descriptionCHR-6494 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11478
  • Product descriptionCHR-6494 ≥98%
  • Packaging5mg
  • Price$93
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number11478
  • Product descriptionCHR-6494 ≥98%
  • Packaging10mg
  • Price$166
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0994
  • Product descriptionCHR-6494 98.70%
  • Packaging5mg
  • Price$60
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0994
  • Product descriptionCHR-6494 98.70%
  • Packaging10mg
  • Price$90
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0994
  • Product descriptionCHR-6494 98.70%
  • Packaging50mg
  • Price$320
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0994
  • Product descriptionCHR-6494 98.70%
  • Packaging100mg
  • Price$550
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003853
  • Product descriptionCHR-6494 98+%
  • Packaging5mg
  • Price$43
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003853
  • Product descriptionCHR-6494 98+%
  • Packaging10mg
  • Price$81
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD31003853
  • Product descriptionCHR-6494 98+%
  • Packaging50mg
  • Price$241
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5064 CHR-6494TFASalt 10mg $145 2021-12-16 Buy
AK Scientific SYN5064 CHR-6494TFASalt 50mg $540 2021-12-16 Buy
ApexBio Technology A3309 CHR-6494 5mg $97 2021-12-16 Buy
ApexBio Technology A3309 CHR-6494 10mg $182 2021-12-16 Buy
ApexBio Technology A3309 CHR-6494 50mg $542 2021-12-16 Buy
ApexBio Technology A3309 CHR-6494 100mg $917 2021-12-16 Buy
Cayman Chemical 11478 CHR-6494 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 11478 CHR-6494 ≥98% 5mg $93 2024-03-01 Buy
Cayman Chemical 11478 CHR-6494 ≥98% 10mg $166 2024-03-01 Buy
ChemScene CS-0994 CHR-6494 98.70% 5mg $60 2021-12-16 Buy
ChemScene CS-0994 CHR-6494 98.70% 10mg $90 2021-12-16 Buy
ChemScene CS-0994 CHR-6494 98.70% 50mg $320 2021-12-16 Buy
ChemScene CS-0994 CHR-6494 98.70% 100mg $550 2021-12-16 Buy
Crysdot CD31003853 CHR-6494 98+% 5mg $43 2021-12-16 Buy
Crysdot CD31003853 CHR-6494 98+% 10mg $81 2021-12-16 Buy
Crysdot CD31003853 CHR-6494 98+% 50mg $241 2021-12-16 Buy
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Properties

Density :1.39±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :13.24±0.40(Predicted)
form :powder
color :white to beige
InChI :1S/C16H16N6.C2HF3O2/c1-2-7-17-15-5-6-16-18-10-14(22(16)21-15)11-3-4-13-12(8-11)9-19-20-13;3-2(4,5)1(6)7/h3-6,8-10H,2,7H2,1H3,(H,17,21)(H,19,20);(H,6,7)
InChIKey :ILWYDZNXJQESDI-UHFFFAOYSA-N
SMILES :OC(=O)C(F)(F)F.CCCNc1ccc2ncc(-c3ccc4[nH]ncc4c3)n2n1

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

CHR-6494 is a haspin protein kinase inhibitor (IC50 = 2 nM) selective over 27 other protein kinases, including Aurora B kinase (IC50 > 1 μM). Haspin is a kinase necessary for mitosis that selectively phosphorylates histone 3 at the threonine 3 residue (H3T3ph). CHR-6494 decreases phosphorylation of H3T3 and arrests the cell cycle in the G2/M phase, which leads to apoptosis. It showed promising results in a xenograft tumor model.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
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$52.00 /5mg
CHR-6494 CAS:1333377-65-3
Wuhan Topule Biopharmaceutical Co., Ltd
Aladdin Scientific
NANJING YINGWEN BIOTECHNOLOGY CO LTD
Amadis Chemical Company Limited Shanghai Boyle Chemical Co., Ltd. BOC Sciences Haoyuan Chemexpress Co., Ltd. MedChemexpress LLC AdooQ BioScience, LLC