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ChemicalBook >> CAS DataBase List >> CID5721353

CID5721353

CID5721353 price.
  • $32 - $1800
  • Product name: CID5721353
  • CAS: 301356-95-6
  • MF: C15H9BrN2O6S2
  • MW: 457.28
  • EINECS:
  • MDL Number:MFCD31729277
  • Synonyms:CID5721353;CID5721353, BCL6 inhibitor;BCL6 inhibitor(CID5721353);CID5721353 BDL6 inhribitor;CID-5721353;CID 5721353;79-6 (CID5721353， BCL6 inhibitor);CID 5721353;CID-5721353;CID 5721353;2-(5-(5-bromo-2-oxoindolin-3-ylidene)-4-oxo-2-thioxothiazolidin-3-yl)succinic acid
Price8 Properties Safety Information Description
8 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 250mg
  • 1g
  • ManufacturerAK Scientific
  • Product number6486CL
  • Product description2-[5-(5-Bromo-2-oxoindol-3-yl)-4-hydroxy-2-sulfanylidene-1,3-thiazol-3-yl]butanedioicacid
  • Packaging1mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number6486CL
  • Product description2-[5-(5-Bromo-2-oxoindol-3-yl)-4-hydroxy-2-sulfanylidene-1,3-thiazol-3-yl]butanedioicacid
  • Packaging5mg
  • Price$313
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number22967
  • Product descriptionCID-5721353
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22967
  • Product descriptionCID-5721353
  • Packaging5mg
  • Price$70
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22967
  • Product descriptionCID-5721353
  • Packaging10mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number22967
  • Product descriptionCID-5721353
  • Packaging25mg
  • Price$190
  • Updated2024-03-01
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9955
  • Product descriptionBCL6inhibitor(CID5721353) >98%
  • Packaging250mg
  • Price$850
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9955
  • Product descriptionBCL6inhibitor(CID5721353) >98%
  • Packaging1g
  • Price$1800
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 6486CL 2-[5-(5-Bromo-2-oxoindol-3-yl)-4-hydroxy-2-sulfanylidene-1,3-thiazol-3-yl]butanedioicacid 1mg $147 2021-12-16 Buy
AK Scientific 6486CL 2-[5-(5-Bromo-2-oxoindol-3-yl)-4-hydroxy-2-sulfanylidene-1,3-thiazol-3-yl]butanedioicacid 5mg $313 2021-12-16 Buy
Cayman Chemical 22967 CID-5721353 1mg $32 2024-03-01 Buy
Cayman Chemical 22967 CID-5721353 5mg $70 2024-03-01 Buy
Cayman Chemical 22967 CID-5721353 10mg $109 2024-03-01 Buy
Cayman Chemical 22967 CID-5721353 25mg $190 2024-03-01 Buy
DC Chemicals DC9955 BCL6inhibitor(CID5721353) >98% 250mg $850 2021-12-16 Buy
DC Chemicals DC9955 BCL6inhibitor(CID5721353) >98% 1g $1800 2021-12-16 Buy

Properties

Density :2.06±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO
form :Solid
pka :3.02±0.23(Predicted)
color :Light brown to brown

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

CID-5721353 is an inhibitor of the transcriptional repressor B cell lymphoma 6 (Bcl-6; Ki = 147 μM). It is selective for Bcl-6 over Kaiso, hypermethylated in cancer 1 (HIC1), and promyelocytic leukemia zinc finger (PLZF) at 50 μM. CID-5721353 is cytotoxic against Bcl-6-dependent SU-DLH-6, SU-DLH-4, Farage, OCI-LY7, OCI-LY1, and OCI-LY10 diffuse large B cell lymphoma (DLBCL) cells (GI50s = 0.024-0.936 mM) but not Bcl-6-independent Toledo or OCI-LY4 DLBCL cells (GI50 = >15 mM for both). It increases expression of the Bcl-6 target genes ATR, TP53, CD69, p21, and CD44 in SU-DLH-6 and SU-DHL-4 cells when used at a concentration of 50 μM. CID-5721353 (50 mg/kg) reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models.

Suppliers and manufacturers

career henan chemical co
CID5721353
$1.00 /1KG
CID5721353 CAS:301356-95-6
TargetMol Chemicals Inc.
CID5721353
$46.00 /5mg
CID5721353 CAS:301356-95-6
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.