Cravatt Reagent
|
- $25 - $2014
- Product name: Cravatt Reagent
- CAS: 1438416-21-7
- MF: C22H21Cl2N3O4
- MW: 462.33
- EINECS:
- MDL Number:MFCD26960823
- Synonyms:2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate;Cravatt Reagent;MJN110;(2-Benzylpiperidin-1-yl)(4-(2′-methoxy-[1,1′-biphenyl]-4-yl)-1H-1,2,3-triazol-1-yl)methanone;KT172;HT-01;N-(5-(3-(5,5-Difluoro-7,9-dimethyl-5H-4l4,5l4-dipyrrolo[1,2-c:2′,1′-f][1,3,2]diazaborinin-3-yl)propanamido)pentyl)-N-phenethyl-4-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-1-carboxamide;KT195
33 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 1mg
- 5mg
- 2x5mg
- 10mg
- 25MG
- 50mg
- 100MG
- 250mg
- 1g
- ManufacturerACHEMBLOCK
- Product numberY228529
- Product descriptionMJN110 97.00%
- Packaging100MG
- Price$435
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY228529
- Product descriptionMJN110 97.00%
- Packaging25MG
- Price$145
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberSYN5203
- Product descriptionMJN110
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberC3024
- Product descriptionMJN110
- Packaging5mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC3024
- Product descriptionMJN110
- Packaging10mg
- Price$85
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberC3024
- Product descriptionMJN110
- Packaging25mg
- Price$190
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-117474
- Product descriptionMJN110 99.83%
- Packaging25mg
- Price$209
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-117474
- Product descriptionMJN110 99.83%
- Packaging50mg
- Price$335
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-117474
- Product descriptionMJN110 99.83%
- Packaging10mg
- Price$95
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-117474
- Product descriptionMJN110 99.83%
- Packaging5mg
- Price$53
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-117474
- Product descriptionMJN110 99.83%
- Packaging100mg
- Price$596
- Updated2026-05-26
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2580
- Product descriptionMJN110 98%
- Packaging2x5mg
- Price$143
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2580
- Product descriptionMJN110
- Packaging5mg
- Price$93.5
- Updated2026-05-19
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2580
- Product descriptionMJN110
- Packaging25mg
- Price$324.5
- Updated2026-05-19
- Buy
- ManufacturerBiosynth
- Product numberNHC41621
- Product descriptionMJN110
- Packaging25mg
- Price$787.25
- Updated2026-06-04
- Buy
- ManufacturerBiosynth
- Product numberNHC41621
- Product descriptionMJN110
- Packaging50mg
- Price$1259
- Updated2026-06-04
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | Y228529 | MJN110 97.00% | 100MG | $435 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y228529 | MJN110 97.00% | 25MG | $145 | 2026-05-27 | Buy |
| AK Scientific | SYN5203 | MJN110 | 10mg | $160 | 2021-12-16 | Buy |
| ApexBio Technology | C3024 | MJN110 | 5mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | C3024 | MJN110 | 10mg | $85 | 2026-05-06 | Buy |
| ApexBio Technology | C3024 | MJN110 | 25mg | $190 | 2026-05-06 | Buy |
| Arctom | HY-117474 | MJN110 99.83% | 25mg | $209 | 2026-05-26 | Buy |
| Arctom | HY-117474 | MJN110 99.83% | 50mg | $335 | 2026-05-26 | Buy |
| Arctom | HY-117474 | MJN110 99.83% | 10mg | $95 | 2026-05-26 | Buy |
| Arctom | HY-117474 | MJN110 99.83% | 5mg | $53 | 2026-05-26 | Buy |
| Arctom | HY-117474 | MJN110 99.83% | 100mg | $596 | 2026-05-26 | Buy |
| Axon Medchem | Axon2580 | MJN110 98% | 2x5mg | $143 | 2021-12-16 | Buy |
| Axon Medchem | Axon2580 | MJN110 | 5mg | $93.5 | 2026-05-19 | Buy |
| Axon Medchem | Axon2580 | MJN110 | 25mg | $324.5 | 2026-05-19 | Buy |
| Biosynth | NHC41621 | MJN110 | 25mg | $787.25 | 2026-06-04 | Buy |
| Biosynth | NHC41621 | MJN110 | 50mg | $1259 | 2026-06-04 | Buy |
Properties
Boiling point :561.5±60.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble20mg/mL, clear
pka :5.07±0.10(Predicted)
form :powder
color :white to beige
InChI :1S/C22H21Cl2N3O4/c23-17-5-1-15(2-6-17)21(16-3-7-18(24)8-4-16)25-11-13-26(14-12-25)22(30)31-27-19(28)9-10-20(27)29/h1-8,21H,9-14H2
InChIKey :BEADRWVIFHOSGN-UHFFFAOYSA-N
SMILES :O=C(ON1C(CCC1=O)=O)N2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)CC2
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: soluble20mg/mL, clear
pka :5.07±0.10(Predicted)
form :powder
color :white to beige
InChI :1S/C22H21Cl2N3O4/c23-17-5-1-15(2-6-17)21(16-3-7-18(24)8-4-16)25-11-13-26(14-12-25)22(30)31-27-19(28)9-10-20(27)29/h1-8,21H,9-14H2
InChIKey :BEADRWVIFHOSGN-UHFFFAOYSA-N
SMILES :O=C(ON1C(CCC1=O)=O)N2CCN(C(C3=CC=C(Cl)C=C3)C4=CC=C(Cl)C=C4)CC2
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Endocannabinoids such as 2-arachidonoyl glycerol (2-AG; ) and arachidonoyl ethanolamide (AEA; ) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. MJN110 is an N-hydroxysuccinimidyl carbamate that inhibits MAGL (IC50 = 9.1 nM) and to a lesser extent ABHD6 with potent selectivity over FAAH (IC50 > 10 μM) and other brain serine hydrolases. It can inhibit 2-AG hydrolysis (IC50 = 2.1 nM) with no effect on AEA hydrolysis up to 50 μM. At 5 mg/kg, MJN110 has been shown to alleviate mechanical allodynia in a rat model of diabetic neuropathy.Suppliers and manufacturers
HANGZHOU CLAP TECHNOLOGY CO.,LTD
TargetMol Chemicals Inc.
Amadis Chemical Company Limited
BOC Sciences
Sigma-Aldrich
Shanghai Beckham Medical Technology Co., Ltd
Pharmacodia (Beijing) Co.,Ltd
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
