DDD85646
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- $97 - $672
- Product name: DDD85646
- CAS: 1215010-55-1
- MF: C21H24Cl2N6O2S
- MW: 495.43
- EINECS:
- MDL Number:
- Synonyms:DDD85646;DDD 85646 (DDD85646);Benzenesulfonamide, 2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-;DDD85646 Hydrochloride;African trypanosomiasis,N-myristoyltransferase,inhibit,DDD85646,Inhibitor,trypanosoma brucei,DNA/RNA Synthesis,NMT,Parasite;2,6-dichloro-4-[2-(1-piperazinyl)-4-pyridinyl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)-benzenesulfonamide;2,6-dichloro-4-[2-(piperazin-1-yl)pyridin-4-yl]-N-(1,3,5-trimethyl-1H-pyrazol-4-yl)benzene-1-sulfonamide;DDD85646, 10 mM in DMSO
7 prices
Selected condition：
Brand
- AK Scientific
- Cayman Chemical
- TRC
- Usbiological
Package
- 1mg
- 2.5mg
- 5mg
- 10mg
- ManufacturerAK Scientific
- Product number2777DF
- Product description2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide
- Packaging1mg
- Price$206
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product number2777DF
- Product description2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide
- Packaging5mg
- Price$553
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number13839
- Product descriptionDDD85646 ≥98%
- Packaging1mg
- Price$97
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13839
- Product descriptionDDD85646 ≥98%
- Packaging5mg
- Price$410
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number13839
- Product descriptionDDD85646 ≥98%
- Packaging10mg
- Price$672
- Updated2024-03-01
- Buy
- ManufacturerTRC
- Product numberD195323
- Product descriptionDDD85646
- Packaging2.5mg
- Price$265
- Updated2021-12-16
- Buy
- ManufacturerUsbiological
- Product number445831
- Product descriptionDDD85646
- Packaging1mg
- Price$410
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | 2777DF | 2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide | 1mg | $206 | 2021-12-16 | Buy |
| AK Scientific | 2777DF | 2,6-Dichloro-4-(2-Piperazin-1-Ylpyridin-4-Yl)-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide | 5mg | $553 | 2021-12-16 | Buy |
| Cayman Chemical | 13839 | DDD85646 ≥98% | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 13839 | DDD85646 ≥98% | 5mg | $410 | 2024-03-01 | Buy |
| Cayman Chemical | 13839 | DDD85646 ≥98% | 10mg | $672 | 2024-03-01 | Buy |
| TRC | D195323 | DDD85646 | 2.5mg | $265 | 2021-12-16 | Buy |
| Usbiological | 445831 | DDD85646 | 1mg | $410 | 2021-12-16 | Buy |
Properties
Melting point :>215°C (dec.)
Boiling point :684.3±65.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly, Heated), Methanol (Slightly)
form :Solid
pka :7.04±0.50(Predicted)
color :Off-White to Yellow
Boiling point :684.3±65.0 °C(Predicted)
Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly, Heated), Methanol (Slightly)
form :Solid
pka :7.04±0.50(Predicted)
color :Off-White to Yellow
Safety Information
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Description
DDD85646 is a moderately bioavailable pyrazole sulphonamide inhibitor of T. brucei N-myristoyltransferase (TbNMT) with an apparent Ki value of 1.44 nM. T. brucei is the parasite responsible for human African trypanosomiasis (HAT), also known as African sleeping sickness, and is transmitted through the tsetse fly. DDD85646 administration in mice (12.5 mg/kg for four days) ameliorated T. brucei in an acute mouse model of HAT. It less potently inhibits growth of T. cruzi (EC50 = 6.9 μM).Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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Wuhan Jingkang en Biomedical Technology Co., Ltd
Shanghai Lollane Biological Technology Co.,Ltd.
Shanghai EFE Biological Technology Co., Ltd.
Shanghai YuanYe Biotechnology Co., Ltd.
Shanghai Chaolan Chemical Technology Center
Shanghai Hongye Biotechnology Co. Ltd
