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ChemicalBook >> CAS DataBase List >> DS-437

DS-437

DS-437 price.
  • $36 - $700
  • Product name: DS-437
  • CAS: 1674364-87-4
  • MF: C15H23N7O4S
  • MW: 397.45
  • EINECS:
  • MDL Number:MFCD32661891
  • Synonyms:DS-437;DS-437 (DS437;Adenosine, 5'-S-[2-[[(ethylamino)carbonyl]amino]ethyl]-5'-thio-;DS-437 >=98% (HPLC)
Price12 Properties Safety Information Description
12 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • Sigma-Aldrich
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number1078EH
  • Product description1-[2-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea
  • Packaging1mg
  • Price$137
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number1078EH
  • Product description1-[2-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea
  • Packaging5mg
  • Price$213
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29476
  • Product descriptionDS-437
  • Packaging1mg
  • Price$36
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29476
  • Product descriptionDS-437
  • Packaging5mg
  • Price$105
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29476
  • Product descriptionDS-437
  • Packaging10mg
  • Price$188
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0084441
  • Product descriptionDS-437 99.61%
  • Packaging100mg
  • Price$700
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0084441
  • Product descriptionDS-437 99.61%
  • Packaging50mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0084441
  • Product descriptionDS-437 99.61%
  • Packaging25mg
  • Price$280
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0084441
  • Product descriptionDS-437 99.61%
  • Packaging10mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0084441
  • Product descriptionDS-437 99.61%
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1516
  • Product descriptionDS-437 ≥98% (HPLC)
  • Packaging5MG
  • Price$105
  • Updated2023-06-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1516
  • Product descriptionDS-437 ≥98% (HPLC)
  • Packaging25MG
  • Price$424
  • Updated2023-06-20
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1078EH 1-[2-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea 1mg $137 2021-12-16 Buy
AK Scientific 1078EH 1-[2-[[(2S,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methylsulfanyl]ethyl]-3-ethylurea 5mg $213 2021-12-16 Buy
Cayman Chemical 29476 DS-437 1mg $36 2024-03-01 Buy
Cayman Chemical 29476 DS-437 5mg $105 2024-03-01 Buy
Cayman Chemical 29476 DS-437 10mg $188 2024-03-01 Buy
ChemScene CS-0084441 DS-437 99.61% 100mg $700 2021-12-16 Buy
ChemScene CS-0084441 DS-437 99.61% 50mg $450 2021-12-16 Buy
ChemScene CS-0084441 DS-437 99.61% 25mg $280 2021-12-16 Buy
ChemScene CS-0084441 DS-437 99.61% 10mg $130 2021-12-16 Buy
ChemScene CS-0084441 DS-437 99.61% 5mg $80 2021-12-16 Buy
Sigma-Aldrich SML1516 DS-437 ≥98% (HPLC) 5MG $105 2023-06-20 Buy
Sigma-Aldrich SML1516 DS-437 ≥98% (HPLC) 25MG $424 2023-06-20 Buy

Properties

Density :1.71±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:125.0(Max Conc. mg/mL);314.5(Max Conc. mM)
pka :13.13±0.70(Predicted)
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:

Description

DS-437 is a dual inhibitor of protein arginine methyltransferase 5 (PRMT5) and PRMT7 (IC50s = 5.9 and 6 μM, respectively). It is selective for PRMT5 and PRMT7 over a panel of 29 additional protein, DNA, and RNA methyltransferases at 50 μM, but also inhibits DNMT3A and DNMT3B (IC50s = 52 and 62 μM, respectively). DS-437 (2.5 and 10 μM) inhibits symmetrical arginine dimethylation of FOXP3 in HEK293T cells, as well as symmetrical arginine dimethylation of p60 and the ribonucleoproteins SmD1/D3 and SmB/B’ in MDA-MB-231 cells in a concentration-dependent manner. It inhibits the ability of regulatory T cells (Tregs) to suppress effector T cell (Teff) proliferation in vitro in human and murine Treg suppression assays. DS-437 (10 mg/kg five times per week) reduces tumor growth in a CT26Her2 murine colon cancer model when administered in combination with the anti-p185erbB2/neu antibody 4D5.

Suppliers and manufacturers

TargetMol Chemicals Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Aladdin Scientific Sigma-Aldrich Shanghai Hongye Biotechnology Co. Ltd DC Chemicals Energy Chemical Beijing Jin Ming Biotechnology Co., Ltd. InvivoChem TargetMol Chemicals Inc.