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ChemicalBook >> CAS DataBase List >> E6005

E6005

E6005 price.
  • $16 - $1800
  • Product name: E6005
  • CAS: 947620-48-6
  • MF: C26H24N4O5
  • MW: 472.49
  • EINECS:
  • MDL Number:MFCD28502071
  • Synonyms:E6005;RVT-501;E 6005: RVT-501;METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE;RVT-501 E6005;methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate;CS-2517;E 6005;E-6005
Price30 Properties Safety Information Description
30 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Biosynth
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
Package
  • 10mM*1mLinDMSO
  • 1mg
  • 2mg
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250MG
  • 1G
  • Manufactureraablocks
  • Product numberAA00IIG2
  • Product descriptionMethyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate 98%
  • Packaging1mg
  • Price$16
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00IIG2
  • Product descriptionMethyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate ≥96%
  • Packaging2mg
  • Price$18
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00IIG2
  • Product descriptionMethyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate 98%
  • Packaging5mg
  • Price$35
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00IIG2
  • Product descriptionMethyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate 98%
  • Packaging10mg
  • Price$51
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00IIG2
  • Product descriptionMethyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate 98%
  • Packaging25mg
  • Price$86
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00IIG2
  • Product descriptionMethyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate ≥96%
  • Packaging50mg
  • Price$165
  • Updated2026-05-29
  • Buy
  • Manufactureraablocks
  • Product numberAA00IIG2
  • Product descriptionMethyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate ≥96%
  • Packaging100mg
  • Price$279
  • Updated2026-05-29
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberL22506
  • Product descriptionE-6005 98%
  • Packaging100MG
  • Price$200
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberL22506
  • Product descriptionE-6005 98%
  • Packaging250MG
  • Price$400
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberL22506
  • Product descriptionE-6005 98%
  • Packaging1G
  • Price$1005
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product number1822DC
  • Product descriptionMethyl4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate
  • Packaging5mg
  • Price$203
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth
  • Product numberXMB62048
  • Product descriptionRVT 501
  • Packaging100mg
  • Price$1383
  • Updated2026-06-05
  • Buy
  • ManufacturerBiosynth
  • Product numberXMB62048
  • Product descriptionRVT 501
  • Packaging50mg
  • Price$993.5
  • Updated2026-06-05
  • Buy
  • ManufacturerCayman Chemical
  • Product number30203
  • Product descriptionE6005 ≥98%
  • Packaging25mg
  • Price$423
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number30203
  • Product descriptionE6005 ≥98%
  • Packaging10mg
  • Price$190
  • Updated2026-04-30
  • Buy
  • ManufacturerCayman Chemical
  • Product number30203
  • Product descriptionE6005 ≥98%
  • Packaging5mg
  • Price$105
  • Updated2026-04-30
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00IIG2 Methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate 98% 1mg $16 2026-05-29 Buy
aablocks AA00IIG2 Methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate ≥96% 2mg $18 2026-05-29 Buy
aablocks AA00IIG2 Methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate 98% 5mg $35 2026-05-29 Buy
aablocks AA00IIG2 Methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate 98% 10mg $51 2026-05-29 Buy
aablocks AA00IIG2 Methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate 98% 25mg $86 2026-05-29 Buy
aablocks AA00IIG2 Methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate ≥96% 50mg $165 2026-05-29 Buy
aablocks AA00IIG2 Methyl 4-({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}carbamoyl)benzoate ≥96% 100mg $279 2026-05-29 Buy
ACHEMBLOCK L22506 E-6005 98% 100MG $200 2026-05-27 Buy
ACHEMBLOCK L22506 E-6005 98% 250MG $400 2026-05-27 Buy
ACHEMBLOCK L22506 E-6005 98% 1G $1005 2026-05-27 Buy
AK Scientific 1822DC Methyl4-((3-(6,7-dimethoxy-2-(methylamino)quinazolin-4-yl)phenyl)carbamoyl)benzoate 5mg $203 2021-12-16 Buy
Biosynth XMB62048 RVT 501 100mg $1383 2026-06-05 Buy
Biosynth XMB62048 RVT 501 50mg $993.5 2026-06-05 Buy
Cayman Chemical 30203 E6005 ≥98% 25mg $423 2026-04-30 Buy
Cayman Chemical 30203 E6005 ≥98% 10mg $190 2026-04-30 Buy
Cayman Chemical 30203 E6005 ≥98% 5mg $105 2026-04-30 Buy
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Properties

storage temp. :Store at -20°C
solubility :DMSO:25.0(Max Conc. mg/mL);52.9(Max Conc. mM)
form :A solid
color :Light yellow to yellow

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H320 Causes eye irritation Serious eye damage/eye irritation Category 2B Warning P264, P305+P351+P338,P337+P313
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

E6005 is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 μM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM). Topical application of E6005 (0.003-0.3%) reduces ear thickness in a mouse model of oxazolone-induced skin inflammation, as well as reduces oxazolone-induced scratching in mice. It reduces the severity of skin lesions in a model of mite-induced atopic dermatitis. Topical application of E6005 (0.03%) also inhibits the production of leukotriene B4 (LTB4; ) in mouse skin, as well as reduces scratching and cutaneous nerve firing induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 in mice.

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Suppliers and manufacturers

Shanghai Boyle Chemical Co., Ltd. MedChemexpress LLC Nanjing Dulai Biotechnology Co., Ltd. Shanghai Lollane Biological Technology Co.,Ltd. Shanghaizehan biopharma technology co., Ltd. Guangzhou Zhiya Chemdrugs Co.,Ltd Shanghai EFE Biological Technology Co., Ltd. Lanzhou Angeli Biochemical Technology Co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. ShangHai Biochempartner Co.,Ltd