Fruquintinib
|
- $34 - $1700
- Product name: Fruquintinib
- CAS: 1194506-26-7
- MF: C21H19N3O5
- MW: 393.39
- EINECS:-0
- MDL Number:MFCD28502149
- Synonyms:Fruquintinib|HMPL-013;Fruquintinib;6-(6,7-dimethoxyquinazolin-4-yloxy)-N,2-dimethylbenzofuran-3-carboxamide;HMPL-013;3-Benzofurancarboxamide, 6-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-;6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-3-benzofurancarboxamide;R-228060;6-[(6,7-Dimethoxy-4-quinazolinyl)oxy]-N,2-dimethyl-1-benzofuran-3-carboxamide
50 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
Package
- 10mg
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO
- 5MG
- 25MG
- 50mg
- 100MG
- 250mg
- 1G
- ManufacturerACHEMBLOCK
- Product numberM15372
- Product descriptionFruquintinib 98%
- Packaging5MG
- Price$34
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15372
- Product descriptionFruquintinib 98%
- Packaging5MG
- Price$34
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15372
- Product descriptionFruquintinib 98%
- Packaging25MG
- Price$89
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15372
- Product descriptionFruquintinib 98%
- Packaging25MG
- Price$89
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15372
- Product descriptionFruquintinib 98%
- Packaging100MG
- Price$221
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15372
- Product descriptionFruquintinib 98%
- Packaging100MG
- Price$221
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15372
- Product descriptionFruquintinib 98%
- Packaging1G
- Price$833
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberM15372
- Product descriptionFruquintinib 98%
- Packaging1G
- Price$833
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3340DF
- Product descriptionFruquintinib
- Packaging50mg
- Price$343
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0026222
- Product descriptionFRUQUINTINIB 95.00%
- Packaging5MG
- Price$501.66
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5864
- Product descriptionFruquintinib(HMPL-013)
- Packaging100mg
- Price$750
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB5864
- Product descriptionFruquintinib(HMPL-013)
- Packaging100mg
- Price$420
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5864
- Product descriptionFruquintinib(HMPL-013)
- Packaging50mg
- Price$240
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5864
- Product descriptionFruquintinib(HMPL-013)
- Packaging5mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5864
- Product descriptionFruquintinib(HMPL-013)
- Packaging10mM(in1mLDMSO)
- Price$55
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB5864
- Product descriptionFruquintinib(HMPL-013)
- Packaging10mg
- Price$60
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | M15372 | Fruquintinib 98% | 5MG | $34 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15372 | Fruquintinib 98% | 5MG | $34 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15372 | Fruquintinib 98% | 25MG | $89 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15372 | Fruquintinib 98% | 25MG | $89 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15372 | Fruquintinib 98% | 100MG | $221 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15372 | Fruquintinib 98% | 100MG | $221 | 2026-05-27 | Buy |
| ACHEMBLOCK | M15372 | Fruquintinib 98% | 1G | $833 | 2026-05-25 | Buy |
| ACHEMBLOCK | M15372 | Fruquintinib 98% | 1G | $833 | 2026-05-27 | Buy |
| AK Scientific | 3340DF | Fruquintinib | 50mg | $343 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0026222 | FRUQUINTINIB 95.00% | 5MG | $501.66 | 2021-12-16 | Buy |
| ApexBio Technology | B5864 | Fruquintinib(HMPL-013) | 100mg | $750 | 2021-12-16 | Buy |
| ApexBio Technology | B5864 | Fruquintinib(HMPL-013) | 100mg | $420 | 2026-05-06 | Buy |
| ApexBio Technology | B5864 | Fruquintinib(HMPL-013) | 50mg | $240 | 2026-05-06 | Buy |
| ApexBio Technology | B5864 | Fruquintinib(HMPL-013) | 5mg | $50 | 2026-05-06 | Buy |
| ApexBio Technology | B5864 | Fruquintinib(HMPL-013) | 10mM(in1mLDMSO) | $55 | 2026-05-06 | Buy |
| ApexBio Technology | B5864 | Fruquintinib(HMPL-013) | 10mg | $60 | 2026-05-06 | Buy |
Properties
Boiling point :600.5±55.0 °C(Predicted)
Density :1.302±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 5 mg/ml).
pka :14.35±0.46(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI :InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)
InChIKey :BALLNEJQLSTPIO-UHFFFAOYSA-N
SMILES :O1C2=CC(OC3=C4C(=NC=N3)C=C(OC)C(OC)=C4)=CC=C2C(C(NC)=O)=C1C
Density :1.302±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO (up to 5 mg/ml).
pka :14.35±0.46(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI :InChI=1S/C21H19N3O5/c1-11-19(20(25)22-2)13-6-5-12(7-16(13)28-11)29-21-14-8-17(26-3)18(27-4)9-15(14)23-10-24-21/h5-10H,1-4H3,(H,22,25)
InChIKey :BALLNEJQLSTPIO-UHFFFAOYSA-N
SMILES :O1C2=CC(OC3=C4C(=NC=N3)C=C(OC)C(OC)=C4)=CC=C2C(C(NC)=O)=C1C
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Fruquintinib is a VEGFR inhibitor (IC50s = 33, 35, and 0.5 nM for VEGFR1, -2, and -3, respectively). It also inhibits RET, FGFR1, and c-Kit (IC50s = 128, 181, and 458 nM, respectively) in a panel of 253 kinases. Fruquintinib inhibits VEGF-A-induced proliferation of human umbilical vein endothelial cells (HUVECs) and VEGF-C-induced proliferation of human lymphatic endothelial cells (HLECs; IC50s = 1.7 and 4.2 nM, respectively). It decreases tube formation by HUVECs by 74 and 94% when used at concentrations of 30 and 300 nM, respectively. Fruquintinib (0.5-20 mg/kg per day for 21 days) reduces tumor growth in BGC-823, HT-29, Caki-1, and NCI H460 mouse xenograft models.Related product price
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