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ChemicalBook >> CAS DataBase List >> G-5555

G-5555

G-5555 price.
  • $41 - $3196
  • Product name: G-5555
  • CAS: 1648863-90-4
  • MF: C25H25ClN6O3
  • MW: 492.96
  • EINECS:
  • MDL Number:MFCD28506227
  • Synonyms:G-5555;8-(((2r,5r)-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(met;G5555;G 5555;8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one;Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-[(trans-5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)-;PAK1 inhibitor (g-5555);p21 activated kinases,G-5555,PAK,Inhibitor,G 5555,inhibit,G5555;8-((trans-5-Amino-1,3-dioxan-2-yl)methyl)-6-(2-chloro-4-(6-methylpyridin-2-yl)phenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
Price50 Properties Safety Information Description
50 prices
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  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • Arctom
  • Biorbyt Ltd
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
Package
  • 500μg
  • 10mg
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  • 1g
  • 10
  • 10mM*1mLinDMSO(Solution)
  • 1mg
  • 2.5mg
  • 5mg
  • 25mg
  • 50mg
  • 100mg
  • 10mM*1mLinDMSO(Solid+Solvent)
  • Manufactureraablocks
  • Product numberAA00ABOV
  • Product descriptionG 5555 99%
  • Packaging10mg
  • Price$93
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABOV
  • Product descriptionG 5555 99%
  • Packaging25mg
  • Price$209
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABOV
  • Product descriptionG 5555 99%
  • Packaging50mg
  • Price$372
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABOV
  • Product descriptionG 5555 99%
  • Packaging100mg
  • Price$639
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABOV
  • Product descriptionG 5555 99%
  • Packaging5mg
  • Price$64
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00ABOV
  • Product descriptionG 5555 99%
  • Packaging1mg
  • Price$41
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberZ238153
  • Product descriptionrel-8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one 98%
  • Packaging25MG
  • Price$355
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product numberZ238153
  • Product descriptionrel-8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one 98%
  • Packaging100MG
  • Price$920
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product number9602EB
  • Product description8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one
  • Packaging5mg
  • Price$452
  • Updated2021-12-16
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  • ManufacturerAK Scientific
  • Product number9602EB
  • Product description8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one
  • Packaging10mg
  • Price$726
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number9602EB
  • Product description8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one
  • Packaging1mg
  • Price$174
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberHY-19635
  • Product descriptionG-5555 99.88%
  • Packaging10mg
  • Price$152
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberHY-19635
  • Product descriptionG-5555 99.88%
  • Packaging5mg
  • Price$105
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberHY-19635
  • Product descriptionG-5555 99.88%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$108
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-19635
  • Product descriptionG-5555 99.88%
  • Packaging10mM*1mLinDMSO(Solution)
  • Price$114
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-19635
  • Product descriptionG-5555 99.88%
  • Packaging1mg
  • Price$67
  • Updated2026-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00ABOV G 5555 99% 10mg $93 2026-05-28 Buy
aablocks AA00ABOV G 5555 99% 25mg $209 2026-05-28 Buy
aablocks AA00ABOV G 5555 99% 50mg $372 2026-05-28 Buy
aablocks AA00ABOV G 5555 99% 100mg $639 2026-05-28 Buy
aablocks AA00ABOV G 5555 99% 5mg $64 2026-05-28 Buy
aablocks AA00ABOV G 5555 99% 1mg $41 2026-05-28 Buy
ACHEMBLOCK Z238153 rel-8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one 98% 25MG $355 2026-05-27 Buy
ACHEMBLOCK Z238153 rel-8-[(trans-5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methyl-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one 98% 100MG $920 2026-05-27 Buy
AK Scientific 9602EB 8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one 5mg $452 2021-12-16 Buy
AK Scientific 9602EB 8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one 10mg $726 2021-12-16 Buy
AK Scientific 9602EB 8-[(5-Amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one 1mg $174 2021-12-16 Buy
Arctom HY-19635 G-5555 99.88% 10mg $152 2026-05-26 Buy
Arctom HY-19635 G-5555 99.88% 5mg $105 2026-05-26 Buy
Arctom HY-19635 G-5555 99.88% 10mM*1mLinDMSO(Solid+Solvent) $108 2026-05-26 Buy
Arctom HY-19635 G-5555 99.88% 10mM*1mLinDMSO(Solution) $114 2026-05-26 Buy
Arctom HY-19635 G-5555 99.88% 1mg $67 2026-05-26 Buy
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Properties

Boiling point :684.6±65.0 °C(Predicted)
Density :1.363±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
form :A crystalline solid
pka :6.86±0.40(Predicted)
color :White to light yellow

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

G-5555 is an inhibitor of p21-activated kinase 1 (PAK1; Ki = 3.7 nM), a non-receptor serine/threonine kinase involved in tumorigenesis. It is selective for PAK1 over the majority of targets in a panel of 235 kinases but does inhibit PAK2, PAK3, KHS1, LCK, MST3, MST4, SIK2, and YSK1 by greater than 70% with IC50 values ranging from 9 to 52 nM. G-5555 inhibits phosphorylation of MEK, a downstream target of PAK1, in EBC1 cells (IC50 = 69 nM). G-5555 (10, 20, and 30 mg/kg) dose-dependently reduces phosphorylation of MEK in tumors from an H292 non-small cell lung cancer (NSCLC) mouse xenograft model. G-5555 inhibits hERG channels less than 50% at a concentration of 10 μM, indicating the potential for a low risk of QT interval prolongation and potentially fatal arrhythmias.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
G-5555
$48.00
G-5555 CAS:1648863-90-4
BOC Sciences Haoyuan Chemexpress Co., Ltd. Shanghai EFE Biological Technology Co., Ltd. Amadis Chemical Company Limited Musechem Shanghai Zeye Biotechnology Co., Ltd. cjbscvictory Beijing Jin Ming Biotechnology Co., Ltd. ChemeGen