GLIOTOXIN
|
- $63 - $3566
- Product name: GLIOTOXIN
- CAS: 67-99-2
- MF: C13H14N2O4S2
- MW: 326.39
- EINECS:636-170-3
- MDL Number:MFCD00058534
- Synonyms:GLIOTOXIN;GLIOTOXIN, GLADIOCLADIUM FIMBRIATUM;2,3,5A,6-TETRAHYDRO-6-HYDROXY-3(HYROXYMETHYL)-2-METHYL-10H-3A, 10A-EPIDITHIO-PYRAZINOL[1,2ALPHA]INDOLE-1,4-DIONE;(3r-(3-alpha,5a-beta,6-beta,10a-alpha))-ymethyl)-2-methyl ;10h-3,10a-epidithiopyrazino(1,2-a)indole-1,4-dione,2,3,5a,6-hydroxy-3-(hydrox ;aspergillin ;s.n.12870 ;gliotoxin from gliocladium fimbriatum
50 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Apolloscientific
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1
- 1mg
- 2mg
- 5mg
- 10mg
- 20mg
- 25mg
- 50mg
- 100mg
- 10mM*1mLinDMSO(Solid+Solvent)
- 10mM*1mLinDMSO(Solution)
- Manufactureraablocks
- Product numberAA006149
- Product descriptionGliotoxin ≥98%
- Packaging1mg
- Price$63
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006149
- Product descriptionGliotoxin ≥98%
- Packaging5mg
- Price$279
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA006149
- Product descriptionGliotoxin ≥98%
- Packaging10mg
- Price$465
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberU106012
- Product descriptionGliotoxin 98.00%
- Packaging5MG
- Price$605
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberU106012
- Product descriptionGliotoxin 98.00%
- Packaging10MG
- Price$1040
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number8679AJ
- Product descriptionGliotoxin
- Packaging5mg
- Price$337
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4443
- Product descriptionGliotoxin
- Packaging5mg
- Price$325
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA4443
- Product descriptionGliotoxin
- Packaging10mg
- Price$575
- Updated2026-05-06
- Buy
- ManufacturerApolloscientific
- Product numberBIG1003
- Product descriptionGliotoxin from Gliocladium fimbriatum
- Packaging25mg
- Price$1084
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIG1003
- Product descriptionGliotoxin from Gliocladium fimbriatum
- Packaging50mg
- Price$1966
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIG1003
- Product descriptionGliotoxin from Gliocladium fimbriatum
- Packaging100mg
- Price$3566
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIG1003
- Product descriptionGliotoxin from Gliocladium fimbriatum
- Packaging5mg
- Price$270
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIG1003
- Product descriptionGliotoxin from Gliocladium fimbriatum
- Packaging1mg
- Price$73
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIG1003
- Product descriptionGliotoxin from Gliocladium fimbriatum
- Packaging10mg
- Price$490
- Updated2026-06-04
- Buy
- ManufacturerArctom
- Product numberHY-N6727
- Product descriptionGliotoxin 99.50%
- Packaging5mg
- Price$500
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-N6727
- Product descriptionGliotoxin 99.50%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$551
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA006149 | Gliotoxin ≥98% | 1mg | $63 | 2026-05-28 | Buy |
| aablocks | AA006149 | Gliotoxin ≥98% | 5mg | $279 | 2026-05-28 | Buy |
| aablocks | AA006149 | Gliotoxin ≥98% | 10mg | $465 | 2026-05-28 | Buy |
| ACHEMBLOCK | U106012 | Gliotoxin 98.00% | 5MG | $605 | 2026-05-27 | Buy |
| ACHEMBLOCK | U106012 | Gliotoxin 98.00% | 10MG | $1040 | 2026-05-27 | Buy |
| AK Scientific | 8679AJ | Gliotoxin | 5mg | $337 | 2021-12-16 | Buy |
| ApexBio Technology | A4443 | Gliotoxin | 5mg | $325 | 2026-05-06 | Buy |
| ApexBio Technology | A4443 | Gliotoxin | 10mg | $575 | 2026-05-06 | Buy |
| Apolloscientific | BIG1003 | Gliotoxin from Gliocladium fimbriatum | 25mg | $1084 | 2026-06-04 | Buy |
| Apolloscientific | BIG1003 | Gliotoxin from Gliocladium fimbriatum | 50mg | $1966 | 2026-06-04 | Buy |
| Apolloscientific | BIG1003 | Gliotoxin from Gliocladium fimbriatum | 100mg | $3566 | 2026-06-04 | Buy |
| Apolloscientific | BIG1003 | Gliotoxin from Gliocladium fimbriatum | 5mg | $270 | 2026-06-04 | Buy |
| Apolloscientific | BIG1003 | Gliotoxin from Gliocladium fimbriatum | 1mg | $73 | 2026-06-04 | Buy |
| Apolloscientific | BIG1003 | Gliotoxin from Gliocladium fimbriatum | 10mg | $490 | 2026-06-04 | Buy |
| Arctom | HY-N6727 | Gliotoxin 99.50% | 5mg | $500 | 2026-05-26 | Buy |
| Arctom | HY-N6727 | Gliotoxin 99.50% | 10mM*1mLinDMSO(Solid+Solvent) | $551 | 2026-05-26 | Buy |
Properties
Melting point :221°C (rough estimate)
Boiling point :699.7±55.0 °C(Predicted)
alpha :D25 -290° (c = 0.08 in ethanol)
Density :1.4069 (rough estimate)
refractive index :1.6510 (estimate)
Flash point :2℃
storage temp. :2-8°C
solubility :chloroform: 10 mg/mL, clear, colorless
form :White solid
pka :12.90±0.40(Predicted)
color :Monoclinic crystals from MeOH
Merck :13,4454
BRN :50675
Stability :Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
InChIKey :FIVPIPIDMRVLAY-RBJBARPLSA-N
SMILES :N12C(=O)[C@@]3(CO)SS[C@@]1(C(=O)N3C)CC1[C@@]2([H])[C@@H](O)C=CC=1
Boiling point :699.7±55.0 °C(Predicted)
alpha :D25 -290° (c = 0.08 in ethanol)
Density :1.4069 (rough estimate)
refractive index :1.6510 (estimate)
Flash point :2℃
storage temp. :2-8°C
solubility :chloroform: 10 mg/mL, clear, colorless
form :White solid
pka :12.90±0.40(Predicted)
color :Monoclinic crystals from MeOH
Merck :13,4454
BRN :50675
Stability :Stable for 2 yeara as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChI :InChI=1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
InChIKey :FIVPIPIDMRVLAY-RBJBARPLSA-N
SMILES :N12C(=O)[C@@]3(CO)SS[C@@]1(C(=O)N3C)CC1[C@@]2([H])[C@@H](O)C=CC=1
Safety Information
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| Signal word: | Danger | ||||||||||||||
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| Precautionary statements: |
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Description
Gliotoxin is an immunosuppressive mycotoxin produced by pathogenic strains of Aspergillus and other fungi. It inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 μM), blocking the degradation of IκBα and preventing the activation of NF-κB. Gliotoxin also induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils. It also inhibits geranylgeranyltransferase I and farnesyltransferase (IC50 = 17 and 80 μM, respectively). Gliotoxin potently suppresses viral infection by Nipah and Hendra virus in vitro (IC50 = 149 and 579 nM, respectively). While gliotoxin production by fungi correlates with invasiveness, its role in aspergillosis remains unclear.More related product prices
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