GNE-0877
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- $16 - $3282.7
- Product name: GNE-0877
- CAS: 1374828-69-9
- MF: C14H16F3N7
- MW: 339.32
- EINECS:-0
- MDL Number:MFCD28098661
- Synonyms:2-Methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)-pyrimidin-2-yl)amino)-1H-pyrazol-;GNE-0877;alpha,alpha,3-Trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile;2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;alpha,alpha,3-Trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile GNE-0877;GNE-0877, >=98%;GNE-0877; GNE 0877; GNE0877.;CS-1275
50 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- ApexBio Technology
- Arctom
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Synthonix
- TRC
Package
- 1mg
- 2mg
- 500μg
- 10mM*1mLinDMSO
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 500mg
- 1G
- 1000mg
- Manufactureraablocks
- Product numberAA009BMU
- Product descriptionGNE-0877 99%
- Packaging25mg
- Price$80
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009BMU
- Product descriptionGNE-0877 99%
- Packaging50mg
- Price$133
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009BMU
- Product descriptionGNE-0877 99%
- Packaging10mg
- Price$41
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009BMU
- Product descriptionGNE-0877 99%
- Packaging5mg
- Price$29
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009BMU
- Product descriptionGNE-0877 99%
- Packaging2mg
- Price$19
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA009BMU
- Product descriptionGNE-0877 99%
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product number10223
- Product descriptionGNE-0877 98%
- Packaging100MG
- Price$105
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product number10223
- Product descriptionGNE-0877 98%
- Packaging100MG
- Price$105
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10223
- Product descriptionGNE-0877 98%
- Packaging1G
- Price$320
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product number10223
- Product descriptionGNE-0877 98%
- Packaging1G
- Price$320
- Updated2026-05-27
- Buy
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging10mg
- Price$465
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging5mg
- Price$284
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging5mg
- Price$198
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging2mg
- Price$88
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging25mg
- Price$665
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4633
- Product descriptionGNE0877
- Packaging25mg
- Price$1008
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA009BMU | GNE-0877 99% | 25mg | $80 | 2026-05-28 | Buy |
| aablocks | AA009BMU | GNE-0877 99% | 50mg | $133 | 2026-05-28 | Buy |
| aablocks | AA009BMU | GNE-0877 99% | 10mg | $41 | 2026-05-28 | Buy |
| aablocks | AA009BMU | GNE-0877 99% | 5mg | $29 | 2026-05-28 | Buy |
| aablocks | AA009BMU | GNE-0877 99% | 2mg | $19 | 2026-05-28 | Buy |
| aablocks | AA009BMU | GNE-0877 99% | 1mg | $16 | 2026-05-28 | Buy |
| ACHEMBLOCK | 10223 | GNE-0877 98% | 100MG | $105 | 2026-05-27 | Buy |
| ACHEMBLOCK | 10223 | GNE-0877 98% | 100MG | $105 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10223 | GNE-0877 98% | 1G | $320 | 2026-05-25 | Buy |
| ACHEMBLOCK | 10223 | GNE-0877 98% | 1G | $320 | 2026-05-27 | Buy |
| ApexBio Technology | B4633 | GNE0877 | 10mg | $465 | 2021-12-16 | Buy |
| ApexBio Technology | B4633 | GNE0877 | 5mg | $284 | 2021-12-16 | Buy |
| ApexBio Technology | B4633 | GNE0877 | 5mg | $198 | 2026-05-06 | Buy |
| ApexBio Technology | B4633 | GNE0877 | 2mg | $88 | 2026-05-06 | Buy |
| ApexBio Technology | B4633 | GNE0877 | 25mg | $665 | 2026-05-06 | Buy |
| ApexBio Technology | B4633 | GNE0877 | 25mg | $1008 | 2021-12-16 | Buy |
Properties
Melting point :121 - 122°C
Boiling point :506.3±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :3.87±0.10(Predicted)
form :Solid
color :White to Off-White
InChI :InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
InChIKey :ZPPUMAMZIMPJGP-UHFFFAOYSA-N
SMILES :N1(C(C)(C)C#N)C=C(NC2=NC=C(C(F)(F)F)C(NC)=N2)C(C)=N1
Boiling point :506.3±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :3.87±0.10(Predicted)
form :Solid
color :White to Off-White
InChI :InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
InChIKey :ZPPUMAMZIMPJGP-UHFFFAOYSA-N
SMILES :N1(C(C)(C)C#N)C=C(NC2=NC=C(C(F)(F)F)C(NC)=N2)C(C)=N1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE 0877 is a selective, brain-penetrable LRRK2 inhibitor (Ki = 0.7 nM). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 3 nM in vivo.More related product prices
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