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ChemicalBook >> CAS DataBase List >> GNE-0877

GNE-0877

GNE-0877 price.
  • $16 - $3282.7
  • Product name: GNE-0877
  • CAS: 1374828-69-9
  • MF: C14H16F3N7
  • MW: 339.32
  • EINECS:-0
  • MDL Number:MFCD28098661
  • Synonyms:2-Methyl-2-(3-methyl-4-((4-(methylamino)-5-(trifluoromethyl)-pyrimidin-2-yl)amino)-1H-pyrazol-;GNE-0877;alpha,alpha,3-Trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile;2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile;alpha,alpha,3-Trimethyl-4-[[4-(methylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1H-pyrazole-1-acetonitrile GNE-0877;GNE-0877, >=98%;GNE-0877; GNE 0877; GNE0877.;CS-1275
Price39 Properties Safety Information Description
39 prices
Selected condition：
Brand
  • aablocks
  • ACHEMBLOCK
  • ApexBio Technology
  • Arctom
  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Synthonix
  • TRC
Package
  • 1mg
  • 10mM*1mLinDMSO
  • 500μg
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100MG
  • 250mg
  • 500mg
  • 1G
  • 1000mg
  • Manufactureraablocks
  • Product numberAA009BMU
  • Product descriptionGNE-0877 99%
  • Packaging1mg
  • Price$16
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009BMU
  • Product descriptionGNE-0877 99%
  • Packaging2mg
  • Price$19
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009BMU
  • Product descriptionGNE-0877 99%
  • Packaging5mg
  • Price$29
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009BMU
  • Product descriptionGNE-0877 99%
  • Packaging10mg
  • Price$41
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009BMU
  • Product descriptionGNE-0877 99%
  • Packaging50mg
  • Price$133
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009BMU
  • Product descriptionGNE-0877 99%
  • Packaging25mg
  • Price$80
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10223
  • Product descriptionGNE-0877 98%
  • Packaging100MG
  • Price$105
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product number10223
  • Product descriptionGNE-0877 98%
  • Packaging1G
  • Price$320
  • Updated2026-05-27
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4633
  • Product descriptionGNE0877
  • Packaging25mg
  • Price$665
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4633
  • Product descriptionGNE0877
  • Packaging10mg
  • Price$316
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4633
  • Product descriptionGNE0877
  • Packaging5mg
  • Price$198
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4633
  • Product descriptionGNE0877
  • Packaging2mg
  • Price$88
  • Updated2026-05-06
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S7367
  • Product descriptionGNE-0877 99.65%
  • Packaging5mg
  • Price$226
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberSLK-S7367
  • Product descriptionGNE-0877 99.65%
  • Packaging25mg
  • Price$900
  • Updated2026-05-26
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181248
  • Product descriptionGNE-0877 >98%
  • Packaging100mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb181248
  • Product descriptionGNE-0877 >98%
  • Packaging250mg
  • Price$1654.1
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009BMU GNE-0877 99% 1mg $16 2026-05-28 Buy
aablocks AA009BMU GNE-0877 99% 2mg $19 2026-05-28 Buy
aablocks AA009BMU GNE-0877 99% 5mg $29 2026-05-28 Buy
aablocks AA009BMU GNE-0877 99% 10mg $41 2026-05-28 Buy
aablocks AA009BMU GNE-0877 99% 50mg $133 2026-05-28 Buy
aablocks AA009BMU GNE-0877 99% 25mg $80 2026-05-28 Buy
ACHEMBLOCK 10223 GNE-0877 98% 100MG $105 2026-05-27 Buy
ACHEMBLOCK 10223 GNE-0877 98% 1G $320 2026-05-27 Buy
ApexBio Technology B4633 GNE0877 25mg $665 2026-05-06 Buy
ApexBio Technology B4633 GNE0877 10mg $316 2026-05-06 Buy
ApexBio Technology B4633 GNE0877 5mg $198 2026-05-06 Buy
ApexBio Technology B4633 GNE0877 2mg $88 2026-05-06 Buy
Arctom SLK-S7367 GNE-0877 99.65% 5mg $226 2026-05-26 Buy
Arctom SLK-S7367 GNE-0877 99.65% 25mg $900 2026-05-26 Buy
Biorbyt Ltd orb181248 GNE-0877 >98% 100mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb181248 GNE-0877 >98% 250mg $1654.1 2021-12-16 Buy
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Properties

Melting point :121 - 122°C
Boiling point :506.3±60.0 °C(Predicted)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
pka :3.87±0.10(Predicted)
form :Solid
color :White to Off-White
InChI :InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
InChIKey :ZPPUMAMZIMPJGP-UHFFFAOYSA-N
SMILES :N1(C(C)(C)C#N)C=C(NC2=NC=C(C(F)(F)F)C(NC)=N2)C(C)=N1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Leucine-rich repeat kinase 2 (LRRK2) is an enzyme that interacts with parkin, a ligase that is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Loss of function of the parkin protein leads to dopaminergic cell death. The development of Parkinson's disease has been strongly associated with mutations in the LRRK2 gene that lead to increased kinase activity. GNE 0877 is a selective, brain-penetrable LRRK2 inhibitor (Ki = 0.7 nM). It inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation with an IC50 value of 3 nM in vivo.

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Suppliers and manufacturers

career henan chemical co
GNE0877
$1.00
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TargetMol Chemicals Inc.
GNE0877
$39.00
GNE0877 CAS:1374828-69-9
Dideu Industries Group Limited
HANGZHOU LEAP CHEM CO., LTD.
TargetMol Chemicals Inc.
Zibo Hangyu Biotechnology Development Co., Ltd
Aladdin Scientific
Amadis Chemical Company Limited Shanghai JingRon Chemical Technology Co., Ltd. Beijing Ouhe Technology Co., Ltd