GNE-3511
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- $28 - $4850
- Product name: GNE-3511
- CAS: 1496581-76-0
- MF: C23H26F2N6O
- MW: 440.49
- EINECS:
- MDL Number:MFCD28502215
- Synonyms:GNE-3511;2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile;2-{[6-(3,3-DIFLUOROPYRROLIDIN-1-YL)-4-[1-(OXETAN-3-YL)PIPERIDIN-4-YL]PYRIDIN-2-YL]AMINO}PYRIDINE-4-CARBONITRILE;CS-2506;GNE3511;GNE 3511;2-((6-(3,3-DIFLUOROPYRROLIDIN-1-YL)-4-(1-(OXETAN-3-YL)PIPERIDIN-4-YL)PYRIDIN-2-YL)AMINO)ISONICOTINONITRILE;4-Pyridinecarbonitrile, 2-[[6-(3,3-difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]-;GNE35Chemicalbook11
47 prices
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Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Apolloscientific
- Arctom
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 500mg
- 1G
- 10 mg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- Manufactureraablocks
- Product numberAA00ABPE
- Product description2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99
- Packaging100mg
- Price$178
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABPE
- Product description2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99
- Packaging50mg
- Price$115
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABPE
- Product description2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99
- Packaging25mg
- Price$79
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABPE
- Product description2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99%
- Packaging10mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABPE
- Product description2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99%
- Packaging5mg
- Price$34
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00ABPE
- Product description2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99%
- Packaging1mg
- Price$28
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging5MG
- Price$40
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging25MG
- Price$65
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging100MG
- Price$195
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging1G
- Price$1050
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3319DW
- Product descriptionCID72547959
- Packaging1mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBISN0038
- Product descriptionGNE-3511 99%
- Packaging1mg
- Price$52
- Updated2026-06-04
- Buy
- ManufacturerArctom
- Product numberBD-A822343
- Product descriptionGNE-3511 99%
- Packaging10mg
- Price$53
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12947
- Product descriptionGNE-3511 99.54%
- Packaging5mg
- Price$56
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12947
- Product descriptionGNE-3511 99.54%
- Packaging10mM*1mLinDMSO(Solid+Solvent)
- Price$57
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12947
- Product descriptionGNE-3511 99.54%
- Packaging10mM*1mLinDMSO(Solution)
- Price$60
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00ABPE | 2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99 | 100mg | $178 | 2026-05-28 | Buy |
| aablocks | AA00ABPE | 2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99 | 50mg | $115 | 2026-05-28 | Buy |
| aablocks | AA00ABPE | 2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99 | 25mg | $79 | 2026-05-28 | Buy |
| aablocks | AA00ABPE | 2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99% | 10mg | $52 | 2026-05-28 | Buy |
| aablocks | AA00ABPE | 2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99% | 5mg | $34 | 2026-05-28 | Buy |
| aablocks | AA00ABPE | 2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile 99% | 1mg | $28 | 2026-05-28 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 5MG | $40 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 25MG | $65 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 100MG | $195 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 1G | $1050 | 2026-05-27 | Buy |
| AK Scientific | 3319DW | CID72547959 | 1mg | $145 | 2021-12-16 | Buy |
| Apolloscientific | BISN0038 | GNE-3511 99% | 1mg | $52 | 2026-06-04 | Buy |
| Arctom | BD-A822343 | GNE-3511 99% | 10mg | $53 | 2026-05-26 | Buy |
| Arctom | HY-12947 | GNE-3511 99.54% | 5mg | $56 | 2026-05-26 | Buy |
| Arctom | HY-12947 | GNE-3511 99.54% | 10mM*1mLinDMSO(Solid+Solvent) | $57 | 2026-05-26 | Buy |
| Arctom | HY-12947 | GNE-3511 99.54% | 10mM*1mLinDMSO(Solution) | $60 | 2026-05-26 | Buy |
Properties
Boiling point :579.0±50.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:25.63(Max Conc. mg/mL);58.18(Max Conc. mM)
Methanol:1.0(Max Conc. mg/mL);2.27(Max Conc. mM) form :A crystalline solid
pka :7.23±0.40(Predicted)
color :Light yellow to yellow
InChIKey :RHFIAUKMKYHHFA-UHFFFAOYSA-N
SMILES :C1(NC2=NC(N3CCC(F)(F)C3)=CC(C3CCN(C4COC4)CC3)=C2)=NC=CC(C#N)=C1
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:25.63(Max Conc. mg/mL);58.18(Max Conc. mM)
Methanol:1.0(Max Conc. mg/mL);2.27(Max Conc. mM) form :A crystalline solid
pka :7.23±0.40(Predicted)
color :Light yellow to yellow
InChIKey :RHFIAUKMKYHHFA-UHFFFAOYSA-N
SMILES :C1(NC2=NC(N3CCC(F)(F)C3)=CC(C3CCN(C4COC4)CC3)=C2)=NC=CC(C#N)=C1
Safety Information
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Description
GNE-3511 is a selective and highly potent inhibitor of dual leucine zipper kinase (DLK). It also inhibits phosphorylated JNKand is highly selective for DLK over other MAP kinases. In an MPTP mouse model of Parkinson’s disease, a high dose of GNE-3511 completely suppresses phosphorylated c-Jun (p-c-Jun) expression, while a low dose moderately reduces its expression. Study has also shown that GNE03511 displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. These results suggest that GNE-3511 may have therapeutic potential in multiple indications.Suppliers and manufacturers
BOC Sciences
Zhejiang J&C Biological Technology Co.,Limited
TargetMol Chemicals Inc.
Zibo Hangyu Biotechnology Development Co., Ltd
HANGZHOU LEAP CHEM CO., LTD.
Aladdin Scientific
Amadis Chemical Company Limited
ShangHai Caerulum Pharma Discovery Co., Ltd.
Bide Pharmatech Ltd.
