GNE-3511
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- $29 - $4850
- Product name: GNE-3511
- CAS: 1496581-76-0
- MF: C23H26F2N6O
- MW: 440.49
- EINECS:
- MDL Number:MFCD28502215
- Synonyms:GNE-3511;2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile;2-{[6-(3,3-DIFLUOROPYRROLIDIN-1-YL)-4-[1-(OXETAN-3-YL)PIPERIDIN-4-YL]PYRIDIN-2-YL]AMINO}PYRIDINE-4-CARBONITRILE;CS-2506;GNE3511;GNE 3511;2-((6-(3,3-DIFLUOROPYRROLIDIN-1-YL)-4-(1-(OXETAN-3-YL)PIPERIDIN-4-YL)PYRIDIN-2-YL)AMINO)ISONICOTINONITRILE;4-Pyridinecarbonitrile, 2-[[6-(3,3-difluoro-1-pyrrolidinyl)-4-[1-(3-oxetanyl)-4-piperidinyl]-2-pyridinyl]amino]-;GNE35Chemicalbook11
52 prices
Selected condition：
Brand
- ACHEMBLOCK
- AK Scientific
- Arctom
- Axon Medchem
- Cayman Chemical
- ChemScene
- DC Chemicals
- Sigma-Aldrich
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10mg
- 5MG
- 10mM*1mLinDMSO
- 10mM*1mLinDMSO(Solution)
- 25MG
- 50mg
- 100MG
- 250mg
- 500mg
- 1G
- 10 mg
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging5MG
- Price$40
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging5MG
- Price$40
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging25MG
- Price$65
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging25MG
- Price$65
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging100MG
- Price$195
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging100MG
- Price$195
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging1G
- Price$1050
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72376
- Product descriptionGNE-3511 98%
- Packaging1G
- Price$1050
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number3319DW
- Product descriptionCID72547959
- Packaging1mg
- Price$145
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberBD-A822343
- Product descriptionGNE-3511 99%
- Packaging50mg
- Price$149
- Updated2026-05-25
- Buy
- ManufacturerArctom
- Product numberBD-A822343
- Product descriptionGNE-3511 99%
- Packaging50mg
- Price$149
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberBD-A822343
- Product descriptionGNE-3511 99%
- Packaging25mg
- Price$90
- Updated2026-05-25
- Buy
- ManufacturerArctom
- Product numberBD-A822343
- Product descriptionGNE-3511 99%
- Packaging25mg
- Price$90
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberSLK-E2378
- Product descriptionGNE-3511 99.9%
- Packaging5mg
- Price$140
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12947
- Product descriptionGNE-3511 99.54%
- Packaging25mg
- Price$143
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12947
- Product descriptionGNE-3511 99.54%
- Packaging50mg
- Price$238
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| ACHEMBLOCK | S72376 | GNE-3511 98% | 5MG | $40 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 5MG | $40 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 25MG | $65 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 25MG | $65 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 100MG | $195 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 100MG | $195 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 1G | $1050 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72376 | GNE-3511 98% | 1G | $1050 | 2026-05-27 | Buy |
| AK Scientific | 3319DW | CID72547959 | 1mg | $145 | 2021-12-16 | Buy |
| Arctom | BD-A822343 | GNE-3511 99% | 50mg | $149 | 2026-05-25 | Buy |
| Arctom | BD-A822343 | GNE-3511 99% | 50mg | $149 | 2026-05-26 | Buy |
| Arctom | BD-A822343 | GNE-3511 99% | 25mg | $90 | 2026-05-25 | Buy |
| Arctom | BD-A822343 | GNE-3511 99% | 25mg | $90 | 2026-05-26 | Buy |
| Arctom | SLK-E2378 | GNE-3511 99.9% | 5mg | $140 | 2026-05-26 | Buy |
| Arctom | HY-12947 | GNE-3511 99.54% | 25mg | $143 | 2026-05-26 | Buy |
| Arctom | HY-12947 | GNE-3511 99.54% | 50mg | $238 | 2026-05-26 | Buy |
Properties
Boiling point :579.0±50.0 °C(Predicted)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:25.63(Max Conc. mg/mL);58.18(Max Conc. mM)
Methanol:1.0(Max Conc. mg/mL);2.27(Max Conc. mM) form :A crystalline solid
pka :7.23±0.40(Predicted)
color :Light yellow to yellow
InChIKey :RHFIAUKMKYHHFA-UHFFFAOYSA-N
SMILES :C1(NC2=NC(N3CCC(F)(F)C3)=CC(C3CCN(C4COC4)CC3)=C2)=NC=CC(C#N)=C1
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:25.63(Max Conc. mg/mL);58.18(Max Conc. mM)
Methanol:1.0(Max Conc. mg/mL);2.27(Max Conc. mM) form :A crystalline solid
pka :7.23±0.40(Predicted)
color :Light yellow to yellow
InChIKey :RHFIAUKMKYHHFA-UHFFFAOYSA-N
SMILES :C1(NC2=NC(N3CCC(F)(F)C3)=CC(C3CCN(C4COC4)CC3)=C2)=NC=CC(C#N)=C1
Safety Information
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Description
GNE-3511 is a selective and highly potent inhibitor of dual leucine zipper kinase (DLK). It also inhibits phosphorylated JNKand is highly selective for DLK over other MAP kinases. In an MPTP mouse model of Parkinson’s disease, a high dose of GNE-3511 completely suppresses phosphorylated c-Jun (p-c-Jun) expression, while a low dose moderately reduces its expression. Study has also shown that GNE03511 displayed concentration-dependent protection of neurons from degeneration in vitro and demonstrated dose-dependent activity in two different animal models of disease. These results suggest that GNE-3511 may have therapeutic potential in multiple indications.Suppliers and manufacturers
ATK CHEMICAL COMPANY LIMITED
BOC Sciences
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Chemia Biotechnology（Shanghai） Co., Ltd
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Hangzhou MolCore BioPharmatech Co.,Ltd.
TargetMol Chemicals Inc.
ShenZhen Trendseen Biological Technology Co.,Ltd.
