GW4869
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- $38 - $3196
- Product name: GW4869
- CAS: 6823-69-4
- MF: C30H29ClN6O2
- MW: 541.05
- EINECS:
- MDL Number:MFCD06411564
- Synonyms:N-SMase Inhibitor;2-PropenaMide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-iMidazol-2-yl)phenyl]-, hydrochloride (1:2);4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride;GW4869/GW-4869;N-SMase Inhibitor, GW4869 - CAS 6823-69-4 - Calbiochem;CS-2410;GW4869 dihydrochloride;GW4869;GW 4869 HYDROCHLORIDE HYDRATE
66 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Ambeed
- American Custom Chemicals Corporation
- Apolloscientific
- Arctom
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
Package
- 10mM*1mLinDMSO
- 500μg
- 1mg
- 2mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100MG
- 250mg
- 500mg
- 1G
- Manufactureraablocks
- Product numberAA00FBG1
- Product description2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97%
- Packaging1mg
- Price$38
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBG1
- Product description2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97%
- Packaging2mg
- Price$52
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBG1
- Product description2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97%
- Packaging5mg
- Price$76
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBG1
- Product description2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97%
- Packaging10mg
- Price$128
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FBG1
- Product description2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97%
- Packaging25mg
- Price$192
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65807
- Product description(2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride 98%
- Packaging100MG
- Price$260
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberQ65807
- Product description(2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride 98%
- Packaging1G
- Price$1300
- Updated2026-05-27
- Buy
- ManufacturerAmbeed
- Product numberA213331
- Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
- Packaging1g
- Price$924
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA213331
- Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
- Packaging100mg
- Price$245
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA213331
- Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
- Packaging250mg
- Price$352
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA213331
- Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
- Packaging50mg
- Price$169
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA213331
- Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
- Packaging25mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA213331
- Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
- Packaging5mg
- Price$77
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA213331
- Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA213331
- Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
- Packaging2mg
- Price$59
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0001277
- Product descriptionGW4869 95.00%
- Packaging5MG
- Price$998.61
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00FBG1 | 2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97% | 1mg | $38 | 2026-05-28 | Buy |
| aablocks | AA00FBG1 | 2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97% | 2mg | $52 | 2026-05-28 | Buy |
| aablocks | AA00FBG1 | 2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97% | 5mg | $76 | 2026-05-28 | Buy |
| aablocks | AA00FBG1 | 2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97% | 10mg | $128 | 2026-05-28 | Buy |
| aablocks | AA00FBG1 | 2-Propenamide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-imidazol-2-yl)phenyl]-, hydrochloride (1:2) 97% | 25mg | $192 | 2026-05-28 | Buy |
| ACHEMBLOCK | Q65807 | (2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride 98% | 100MG | $260 | 2026-05-27 | Buy |
| ACHEMBLOCK | Q65807 | (2E,2'E)-3,3'-(1,4-phenylene)bis(N-(4-(4,5-dihydro-1H-imidazol-2-yl)phenyl)acrylamide) dihydrochloride 98% | 1G | $1300 | 2026-05-27 | Buy |
| Ambeed | A213331 | p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% | 1g | $924 | 2021-12-16 | Buy |
| Ambeed | A213331 | p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% | 100mg | $245 | 2021-12-16 | Buy |
| Ambeed | A213331 | p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% | 250mg | $352 | 2021-12-16 | Buy |
| Ambeed | A213331 | p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% | 50mg | $169 | 2021-12-16 | Buy |
| Ambeed | A213331 | p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% | 25mg | $130 | 2021-12-16 | Buy |
| Ambeed | A213331 | p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% | 5mg | $77 | 2021-12-16 | Buy |
| Ambeed | A213331 | p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% | 10mg | $100 | 2021-12-16 | Buy |
| Ambeed | A213331 | p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% | 2mg | $59 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0001277 | GW4869 95.00% | 5MG | $998.61 | 2021-12-16 | Buy |
Properties
Melting point :>300 °C
storage temp. :2-8°C
solubility :DMSO: soluble0.2mg/mL
form :powder
color :light yellow to yellow
InChIKey :NSFKAZDTKIKLKT-LOLTXFFGSA-N
SMILES :Cl.Cl.O=C(Nc1ccc(cc1)C2=NCCN2)\C=C/c3ccc(\C=C/C(=O)Nc4ccc(cc4)C5=NCCN5)cc3
storage temp. :2-8°C
solubility :DMSO: soluble0.2mg/mL
form :powder
color :light yellow to yellow
InChIKey :NSFKAZDTKIKLKT-LOLTXFFGSA-N
SMILES :Cl.Cl.O=C(Nc1ccc(cc1)C2=NCCN2)\C=C/c3ccc(\C=C/C(=O)Nc4ccc(cc4)C5=NCCN5)cc3
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
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Description
Neutral sphingomyelinases mediate the release of ceramide from sphingomyelin in cellular membranes and can be activated by certain stresses. Ceramide can act as a signaling molecule in its own right, or it can be further processed to generate sphingosine (and sphingosine-1-phosphate). GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM), but does not affect acid sphingomyelinase activity. It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM) and TNF-α-induced cell death in MCF-7 cells without interfering with activation of NF-κB or glutathione depletion in response to TNF. GW 4869 also reduces the inhibitory effect of oxidized phospholipid products on lipopolysaccharides-mediated induction of interleukin-8 in human aortic endothelial cells and prevents hypoxia-induced pulmonary vasoconstriction in rats in vivo.Related product price
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