Welcome to chemicalbook!
010-86108875
RFQ
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook >> CAS DataBase List >> GW4869

GW4869

GW4869 price.
  • $33 - $1300
  • Product name: GW4869
  • CAS: 6823-69-4
  • MF: C30H29ClN6O2
  • MW: 541.05
  • EINECS:
  • MDL Number:MFCD06411564
  • Synonyms:N-SMase Inhibitor;2-PropenaMide, 3,3'-(1,4-phenylene)bis[N-[4-(4,5-dihydro-1H-iMidazol-2-yl)phenyl]-, hydrochloride (1:2);4',4''-Di-2-imidazolin-2-yl-p-benzenediacrylanilide dihydrochloride;GW4869/GW-4869;N-SMase Inhibitor, GW4869 - CAS 6823-69-4 - Calbiochem;CS-2410;GW4869 dihydrochloride;GW4869;GW 4869 HYDROCHLORIDE HYDRATE
37 prices
Selected condition:
Brand
  • Ambeed
  • American Custom Chemicals Corporation
  • Arctom
  • Cayman Chemical
  • Chemenu
  • ChemScene
  • Crysdot
  • CSNpharm
  • DC Chemicals
  • Sigma-Aldrich
Package
  • 500μg
  • 1MG
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • ManufacturerAmbeed
  • Product numberA213331
  • Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
  • Packaging2mg
  • Price$59
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA213331
  • Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
  • Packaging5mg
  • Price$77
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA213331
  • Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
  • Packaging10mg
  • Price$100
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA213331
  • Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
  • Packaging25mg
  • Price$130
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA213331
  • Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
  • Packaging50mg
  • Price$169
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA213331
  • Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
  • Packaging100mg
  • Price$245
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA213331
  • Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
  • Packaging250mg
  • Price$352
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA213331
  • Product descriptionp-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97%
  • Packaging1g
  • Price$924
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001277
  • Product descriptionGW4869 95.00%
  • Packaging1MG
  • Price$642.76
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001277
  • Product descriptionGW4869 95.00%
  • Packaging5MG
  • Price$998.61
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0001277
  • Product descriptionGW4869 95.00%
  • Packaging10MG
  • Price$1258.83
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS480426
  • Product descriptionGW4869dihydrochloride 97%
  • Packaging2mg
  • Price$58
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS480426
  • Product descriptionGW4869dihydrochloride 97%
  • Packaging5mg
  • Price$76
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS480426
  • Product descriptionGW4869dihydrochloride 97%
  • Packaging50mg
  • Price$167
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS480426
  • Product descriptionGW4869dihydrochloride 97%
  • Packaging250mg
  • Price$348
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS480426
  • Product descriptionGW4869dihydrochloride 97%
  • Packaging1g
  • Price$915
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Ambeed A213331 p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% 2mg $59 2021-12-16 Buy
Ambeed A213331 p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% 5mg $77 2021-12-16 Buy
Ambeed A213331 p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% 10mg $100 2021-12-16 Buy
Ambeed A213331 p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% 25mg $130 2021-12-16 Buy
Ambeed A213331 p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% 50mg $169 2021-12-16 Buy
Ambeed A213331 p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% 100mg $245 2021-12-16 Buy
Ambeed A213331 p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% 250mg $352 2021-12-16 Buy
Ambeed A213331 p-Benzenediacrylanilide,4′,4′′-di-2-imidazolin-2-yl-,dihydrochloride 97% 1g $924 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001277 GW4869 95.00% 1MG $642.76 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001277 GW4869 95.00% 5MG $998.61 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001277 GW4869 95.00% 10MG $1258.83 2021-12-16 Buy
Arctom AS480426 GW4869dihydrochloride 97% 2mg $58 2021-12-16 Buy
Arctom AS480426 GW4869dihydrochloride 97% 5mg $76 2021-12-16 Buy
Arctom AS480426 GW4869dihydrochloride 97% 50mg $167 2021-12-16 Buy
Arctom AS480426 GW4869dihydrochloride 97% 250mg $348 2021-12-16 Buy
Arctom AS480426 GW4869dihydrochloride 97% 1g $915 2021-12-16 Buy

Properties

Melting point :>300 °C
storage temp. :2-8°C
solubility :DMSO: soluble0.2mg/mL
form :powder
color :light yellow to yellow
InChIKey :NSFKAZDTKIKLKT-LOLTXFFGSA-N
SMILES :Cl.Cl.O=C(Nc1ccc(cc1)C2=NCCN2)\C=C/c3ccc(\C=C/C(=O)Nc4ccc(cc4)C5=NCCN5)cc3

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Neutral sphingomyelinases mediate the release of ceramide from sphingomyelin in cellular membranes and can be activated by certain stresses. Ceramide can act as a signaling molecule in its own right, or it can be further processed to generate sphingosine (and sphingosine-1-phosphate). GW 4869 is a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases (IC50 = 1 μM), but does not affect acid sphingomyelinase activity. It inhibits TNF-α-mediated sphingomyelin hydrolysis (100% inhibition at 20 μM) and TNF-α-induced cell death in MCF-7 cells without interfering with activation of NF-κB or glutathione depletion in response to TNF. GW 4869 also reduces the inhibitory effect of oxidized phospholipid products on lipopolysaccharides-mediated induction of interleukin-8 in human aortic endothelial cells and prevents hypoxia-induced pulmonary vasoconstriction in rats in vivo.