ISRIB (trans-isoMer)
|
- $16 - $2841
- Product name: ISRIB (trans-isoMer)
- CAS: 1597403-47-8
- MF: C22H24Cl2N2O4
- MW: 451.34
- EINECS:
- MDL Number:MFCD27952932
- Synonyms:ISRIB (trans-isoMer);trans-N,N'-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide);N,N'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide) ISRIB(trans-isomer);Acetamide, N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-;N,N'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide];CS-1768;ISRIB - trans-ISRIB;ISRIB (trans-isomer), >98%
67 prices
Selected condition：
Brand
- aablocks
- AccelPharmtech
- ACHEMBLOCK
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- AvaChem
- Axon Medchem
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- Usbiological
Package
- 50
- 1mg
- 5mg
- 10
- 10mg
- 25mg
- 50.00mg
- 50mg
- 100.00mg
- 100mg
- 250.00mg
- 250mg
- 1g
- 5g
- 10mM(in1mLDMSO)
- 10mM*1mLinDMSO
- Manufactureraablocks
- Product numberAA001RAH
- Product descriptionISRIB trans-isomer 98%
- Packaging1mg
- Price$16
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001RAH
- Product descriptionISRIB trans-isomer 98%
- Packaging5mg
- Price$27
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001RAH
- Product descriptionISRIB trans-isomer 98%
- Packaging10mg
- Price$35
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001RAH
- Product descriptionISRIB trans-isomer 98%
- Packaging50mg
- Price$59
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001RAH
- Product descriptionISRIB trans-isomer 98%
- Packaging100mg
- Price$76
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001RAH
- Product descriptionISRIB trans-isomer 97%
- Packaging250mg
- Price$118
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001RAH
- Product descriptionISRIB trans-isomer 97%
- Packaging1g
- Price$268
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA001RAH
- Product descriptionISRIB trans-isomer 97%
- Packaging5g
- Price$807
- Updated2026-05-28
- Buy
- ManufacturerAccelPharmtech
- Product numberXK5972711g
- Product descriptionISRIB trans-isomer 98.00%
- Packaging
- Price$285
- Updated2026-05-21
- Buy
- ManufacturerAccelPharmtech
- Product numberXK597271
- Product descriptionISRIB trans-isomer 98%
- Packaging1g
- Price$285
- Updated2026-05-21
- Buy
- ManufacturerACHEMBLOCK
- Product numberV143092
- Product descriptionISRIB trans-isomer 98%
- Packaging250MG
- Price$175
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberV143092
- Product descriptionISRIB trans-isomer 98%
- Packaging1G
- Price$450
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberV143092
- Product descriptionISRIB trans-isomer 98%
- Packaging5G
- Price$1350
- Updated2026-05-27
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0027387
- Product descriptionTRANS-N,N'-(CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE) 95.00%
- Packaging5MG
- Price$504.28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB3699
- Product descriptionISRIB (trans-isomer)
- Packaging25mg
- Price$219
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB3699
- Product descriptionISRIB (trans-isomer)
- Packaging10mM(in1mLDMSO)
- Price$119
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA001RAH | ISRIB trans-isomer 98% | 1mg | $16 | 2026-05-28 | Buy |
| aablocks | AA001RAH | ISRIB trans-isomer 98% | 5mg | $27 | 2026-05-28 | Buy |
| aablocks | AA001RAH | ISRIB trans-isomer 98% | 10mg | $35 | 2026-05-28 | Buy |
| aablocks | AA001RAH | ISRIB trans-isomer 98% | 50mg | $59 | 2026-05-28 | Buy |
| aablocks | AA001RAH | ISRIB trans-isomer 98% | 100mg | $76 | 2026-05-28 | Buy |
| aablocks | AA001RAH | ISRIB trans-isomer 97% | 250mg | $118 | 2026-05-28 | Buy |
| aablocks | AA001RAH | ISRIB trans-isomer 97% | 1g | $268 | 2026-05-28 | Buy |
| aablocks | AA001RAH | ISRIB trans-isomer 97% | 5g | $807 | 2026-05-28 | Buy |
| AccelPharmtech | XK5972711g | ISRIB trans-isomer 98.00% | $285 | 2026-05-21 | Buy | |
| AccelPharmtech | XK597271 | ISRIB trans-isomer 98% | 1g | $285 | 2026-05-21 | Buy |
| ACHEMBLOCK | V143092 | ISRIB trans-isomer 98% | 250MG | $175 | 2026-05-27 | Buy |
| ACHEMBLOCK | V143092 | ISRIB trans-isomer 98% | 1G | $450 | 2026-05-27 | Buy |
| ACHEMBLOCK | V143092 | ISRIB trans-isomer 98% | 5G | $1350 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | API0027387 | TRANS-N,N'-(CYCLOHEXANE-1,4-DIYL)BIS(2-(4-CHLOROPHENOXY)ACETAMIDE) 95.00% | 5MG | $504.28 | 2021-12-16 | Buy |
| ApexBio Technology | B3699 | ISRIB (trans-isomer) | 25mg | $219 | 2026-05-06 | Buy |
| ApexBio Technology | B3699 | ISRIB (trans-isomer) | 10mM(in1mLDMSO) | $119 | 2026-05-06 | Buy |
Properties
Boiling point :719.0±60.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in EtOH; insoluble in H2O; insoluble in EtOH; ≥8.96 mg/mL in DMSO with gentle warming
form :solid
pka :13.63±0.40(Predicted)
color :White to off-white
InChIKey :HJGMCDHQPXTGAV-IYARVYRRSA-N
SMILES :[C@@H]1(NC(=O)COC2=CC=C(Cl)C=C2)CC[C@@H](NC(=O)COC2=CC=C(Cl)C=C2)CC1
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :insoluble in EtOH; insoluble in H2O; insoluble in EtOH; ≥8.96 mg/mL in DMSO with gentle warming
form :solid
pka :13.63±0.40(Predicted)
color :White to off-white
InChIKey :HJGMCDHQPXTGAV-IYARVYRRSA-N
SMILES :[C@@H]1(NC(=O)COC2=CC=C(Cl)C=C2)CC[C@@H](NC(=O)COC2=CC=C(Cl)C=C2)CC1
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Phosphorylation of eIF2α by several kinases in response to cellular stress, including accumulation of unfolded proteins in the ER, results in a decrease in overall protein synthesis but upregulation of a small number of key regulatory proteins. trans-ISRIB (Integrated Stress Response Inhibitor) is a symmetric bis-glycolamide that inhibits the eIF2α phosphorylation-mediated unfolded protein response following induction of ER stress (IC50 = 5 nM in a cell-reporter assay). Although the mechanism of action is not established, it does not directly inhibit phosphorylation of eIF2α by upstream kinases. trans-ISRIB is able to pass through the blood-brain barrier and significantly enhances learning and memory in mice and rats.Related product price
-
Doxorubicin hydrochloride
$15-7060 -
BEZ235 (NVP-BEZ235, Dactolisib)
$12-1871.1 -
Crizotinib
$5-1963.5
