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ChemicalBook >> CAS DataBase List >> IWP 4

IWP 4

$36 - $1350
Product name: IWP 4
CAS: 686772-17-8
MF: C23H20N4O3S3
MW: 496.62
EINECS:
MDL Number:MFCD04457754
Synonyms:IWP 4;Wnt Inhibitor IWP-4;2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide;N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide;IWP4;IWP 4;CS-2394;Inhibitor of Wnt Production-4;Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-

Price29 Properties Safety Information Description

29 prices

Selected condition：

Brand

Ambeed
ApexBio Technology
Biorbyt Ltd
Biosynth Carbosynth
Cayman Chemical
ChemScene
Crysdot
CSNpharm
DC Chemicals
Sigma-Aldrich
Tocris
TRC
Usbiological

Package

10
1mg
5mg
10mg
25mg
50
50mg
100mg

ManufacturerAmbeed
Product numberA313997
Product description2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+%
Packaging5mg
Price$156
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA313997
Product description2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+%
Packaging10mg
Price$216
Updated2021-12-16
Buy

ManufacturerAmbeed
Product numberA313997
Product description2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+%
Packaging25mg
Price$366
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB4922
Product descriptionIWP4
Packaging10mg
Price$233
Updated2021-12-16
Buy

ManufacturerApexBio Technology
Product numberB4922
Product descriptionIWP4
Packaging50mg
Price$982
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb546176
Product descriptionIWP-4 >98%
Packaging5mg
Price$190.4
Updated2021-12-16
Buy

ManufacturerBiorbyt Ltd
Product numberorb546176
Product descriptionIWP-4 >98%
Packaging25mg
Price$596.7
Updated2021-12-16
Buy

ManufacturerBiosynth Carbosynth
Product numberBI162786
Product descriptionIWP 4
Packaging10mg
Price$175
Updated2021-12-16
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ManufacturerBiosynth Carbosynth
Product numberBI162786
Product descriptionIWP 4
Packaging50mg
Price$769
Updated2021-12-16
Buy

ManufacturerCayman Chemical
Product number13954
Product descriptionIWP-4 ≥95%
Packaging1mg
Price$36
Updated2024-03-01
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ManufacturerCayman Chemical
Product number13954
Product descriptionIWP-4 ≥95%
Packaging5mg
Price$145
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number13954
Product descriptionIWP-4 ≥95%
Packaging10mg
Price$223
Updated2024-03-01
Buy

ManufacturerCayman Chemical
Product number13954
Product descriptionIWP-4 ≥95%
Packaging25mg
Price$510
Updated2024-03-01
Buy

ManufacturerChemScene
Product numberCS-0012738
Product descriptionIWP-4 ≥98.0%
Packaging5mg
Price$115
Updated2021-12-16
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ManufacturerChemScene
Product numberCS-0012738
Product descriptionIWP-4 ≥98.0%
Packaging10mg
Price$180
Updated2021-12-16
Buy

ManufacturerChemScene
Product numberCS-0012738
Product descriptionIWP-4 ≥98.0%
Packaging25mg
Price$420
Updated2021-12-16
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Ambeed	A313997	2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+%	5mg	$156	2021-12-16	Buy
Ambeed	A313997	2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+%	10mg	$216	2021-12-16	Buy
Ambeed	A313997	2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+%	25mg	$366	2021-12-16	Buy
ApexBio Technology	B4922	IWP4	10mg	$233	2021-12-16	Buy
ApexBio Technology	B4922	IWP4	50mg	$982	2021-12-16	Buy
Biorbyt Ltd	orb546176	IWP-4 >98%	5mg	$190.4	2021-12-16	Buy
Biorbyt Ltd	orb546176	IWP-4 >98%	25mg	$596.7	2021-12-16	Buy
Biosynth Carbosynth	BI162786	IWP 4	10mg	$175	2021-12-16	Buy
Biosynth Carbosynth	BI162786	IWP 4	50mg	$769	2021-12-16	Buy
Cayman Chemical	13954	IWP-4 ≥95%	1mg	$36	2024-03-01	Buy
Cayman Chemical	13954	IWP-4 ≥95%	5mg	$145	2024-03-01	Buy
Cayman Chemical	13954	IWP-4 ≥95%	10mg	$223	2024-03-01	Buy
Cayman Chemical	13954	IWP-4 ≥95%	25mg	$510	2024-03-01	Buy
ChemScene	CS-0012738	IWP-4 ≥98.0%	5mg	$115	2021-12-16	Buy
ChemScene	CS-0012738	IWP-4 ≥98.0%	10mg	$180	2021-12-16	Buy
ChemScene	CS-0012738	IWP-4 ≥98.0%	25mg	$420	2021-12-16	Buy

Next Last

Properties

Density :1.51±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :insoluble in H2O; insoluble in EtOH; insoluble in DMSO
pka :9.01±0.70(Predicted)
form :powder
color :white to light brown
InChI :1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
InChIKey :RHUJMHOIQBDFQR-UHFFFAOYSA-N
SMILES :O=C1C2=C(CCS2)N=C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)N1C5=C(OC)C=CC=C5

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning		P264, P270, P301+P312, P330, P501

Precautionary statements:

P280	Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM. IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. This compound has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.

Suppliers and manufacturers

TargetMol Chemicals Inc.

$42.00 /1mg
IWP-4 CAS:686772-17-8

Career Henan Chemica Co

InvivoChem

TargetMol Chemicals Inc.

ShenZhen Trendseen Biological Technology Co.,Ltd.

Aladdin Scientific Dalian Meilun Biotech Co., Ltd. SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD Sigma-Aldrich Shanghai Lollane Biological Technology Co.,Ltd.

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