IWP 4
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- $20 - $1900
- Product name: IWP 4
- CAS: 686772-17-8
- MF: C23H20N4O3S3
- MW: 496.62
- EINECS:
- MDL Number:MFCD04457754
- Synonyms:IWP 4;Wnt Inhibitor IWP-4;2-((3-(2-methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide;N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide;IWP4;IWP 4;CS-2394;Inhibitor of Wnt Production-4;Acetamide, N-(6-methyl-2-benzothiazolyl)-2-[[3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-
47 prices
Selected condition：
Brand
- aablocks
- Ambeed
- ApexBio Technology
- Arctom
- AvaChem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- CSNpharm
- DC Chemicals
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 10
- 1mg
- 5mg
- 50
- 10mg
- 25mg
- 50mg
- 10mM*1mLinDMSO
- 100mg
- 250mg
- 1g
- Manufactureraablocks
- Product numberAA00FHJL
- Product descriptionIWP-4 99%
- Packaging1mg
- Price$20
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHJL
- Product descriptionIWP-4 99%
- Packaging5mg
- Price$46
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHJL
- Product descriptionIWP-4 99%
- Packaging10mg
- Price$68
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHJL
- Product descriptionIWP-4 99%
- Packaging25mg
- Price$116
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHJL
- Product descriptionIWP-4 98%
- Packaging50mg
- Price$197
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA00FHJL
- Product descriptionIWP-4 98%
- Packaging100mg
- Price$333
- Updated2026-05-28
- Buy
- ManufacturerAmbeed
- Product numberA313997
- Product description2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+%
- Packaging25mg
- Price$366
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA313997
- Product description2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+%
- Packaging10mg
- Price$216
- Updated2021-12-16
- Buy
- ManufacturerAmbeed
- Product numberA313997
- Product description2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+%
- Packaging5mg
- Price$156
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB4922
- Product descriptionIWP 4
- Packaging10mg
- Price$166
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB4922
- Product descriptionIWP 4
- Packaging50mg
- Price$656
- Updated2026-05-06
- Buy
- ManufacturerArctom
- Product numberHY-12879
- Product descriptionIWP-4 99.81%
- Packaging50mg
- Price$633
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12879
- Product descriptionIWP-4 99.81%
- Packaging25mg
- Price$399
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12879
- Product descriptionIWP-4 99.81%
- Packaging10mg
- Price$171
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12879
- Product descriptionIWP-4 99.81%
- Packaging5mg
- Price$110
- Updated2026-05-26
- Buy
- ManufacturerArctom
- Product numberHY-12879
- Product descriptionIWP-4 99.81%
- Packaging1mg
- Price$52
- Updated2026-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA00FHJL | IWP-4 99% | 1mg | $20 | 2026-05-28 | Buy |
| aablocks | AA00FHJL | IWP-4 99% | 5mg | $46 | 2026-05-28 | Buy |
| aablocks | AA00FHJL | IWP-4 99% | 10mg | $68 | 2026-05-28 | Buy |
| aablocks | AA00FHJL | IWP-4 99% | 25mg | $116 | 2026-05-28 | Buy |
| aablocks | AA00FHJL | IWP-4 98% | 50mg | $197 | 2026-05-28 | Buy |
| aablocks | AA00FHJL | IWP-4 98% | 100mg | $333 | 2026-05-28 | Buy |
| Ambeed | A313997 | 2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+% | 25mg | $366 | 2021-12-16 | Buy |
| Ambeed | A313997 | 2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+% | 10mg | $216 | 2021-12-16 | Buy |
| Ambeed | A313997 | 2-((3-(2-Methoxyphenyl)-4-oxo-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(6-methylbenzo[d]thiazol-2-yl)acetamide 98+% | 5mg | $156 | 2021-12-16 | Buy |
| ApexBio Technology | B4922 | IWP 4 | 10mg | $166 | 2026-05-06 | Buy |
| ApexBio Technology | B4922 | IWP 4 | 50mg | $656 | 2026-05-06 | Buy |
| Arctom | HY-12879 | IWP-4 99.81% | 50mg | $633 | 2026-05-26 | Buy |
| Arctom | HY-12879 | IWP-4 99.81% | 25mg | $399 | 2026-05-26 | Buy |
| Arctom | HY-12879 | IWP-4 99.81% | 10mg | $171 | 2026-05-26 | Buy |
| Arctom | HY-12879 | IWP-4 99.81% | 5mg | $110 | 2026-05-26 | Buy |
| Arctom | HY-12879 | IWP-4 99.81% | 1mg | $52 | 2026-05-26 | Buy |
Properties
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :insoluble in H2O; insoluble in EtOH; insoluble in DMSO
pka :9.01±0.70(Predicted)
form :powder
color :white to light brown
InChI :1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
InChIKey :RHUJMHOIQBDFQR-UHFFFAOYSA-N
SMILES :O=C1C2=C(CCS2)N=C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)N1C5=C(OC)C=CC=C5
storage temp. :-20°C
solubility :insoluble in H2O; insoluble in EtOH; insoluble in DMSO
pka :9.01±0.70(Predicted)
form :powder
color :white to light brown
InChI :1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
InChIKey :RHUJMHOIQBDFQR-UHFFFAOYSA-N
SMILES :O=C1C2=C(CCS2)N=C(SCC(NC3=NC(C=CC(C)=C4)=C4S3)=O)N1C5=C(OC)C=CC=C5
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
| Hazard statements: |
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| Precautionary statements: |
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Description
Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription. IWP-4 is an inhibitor of Wnt production that impairs Wnt pathway activity in vitro with an IC50 value of 25 nM. IWP-4 inactivates Porcupine, a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 μM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of β-catenin. This compound has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.Related product price
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$42-2395.3
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